Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4526315..4526831 Replicon chromosome
Accession NZ_AP018753
Organism Klebsiella pneumoniae strain KP67

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag D5075_RS22555 Protein ID WP_004178374.1
Coordinates 4526315..4526599 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag D5075_RS22560 Protein ID WP_002886901.1
Coordinates 4526589..4526831 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5075_RS22535 4521799..4522107 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
D5075_RS29385 4522192..4522365 + 174 WP_032408826.1 hypothetical protein -
D5075_RS22540 4522368..4523111 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
D5075_RS22545 4523468..4525606 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
D5075_RS22550 4525847..4526311 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
D5075_RS22555 4526315..4526599 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D5075_RS22560 4526589..4526831 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D5075_RS22565 4526909..4528819 - 1911 WP_004178373.1 BglG family transcription antiterminator -
D5075_RS22570 4528842..4529996 - 1155 WP_004178372.1 lactonase family protein -
D5075_RS22575 4530063..4530803 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T32061 WP_004178374.1 NZ_AP018753:c4526599-4526315 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T32061 NZ_AP018753:c4526599-4526315 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT32061 WP_002886901.1 NZ_AP018753:c4526831-4526589 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT32061 NZ_AP018753:c4526831-4526589 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References