32045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 5080871..5081393 Replicon chromosome
Accession NZ_AP018750
Organism Klebsiella pneumoniae strain KP64

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag D5082_RS25295 Protein ID WP_038991638.1
Coordinates 5080871..5081155 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag D5082_RS25300 Protein ID WP_004181777.1
Coordinates 5081145..5081393 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5082_RS25265 5076071..5077166 + 1096 Protein_4793 conjugal transfer protein TraG N-terminal domain-containing protein -
D5082_RS25270 5077265..5078452 - 1188 WP_043907031.1 transposase -
D5082_RS25275 5078488..5078916 + 429 WP_077256229.1 IS200/IS605 family transposase -
D5082_RS25280 5078995..5079219 + 225 Protein_4796 transposase -
D5082_RS25285 5079491..5080717 - 1227 WP_119355547.1 transposase -
D5082_RS25290 5080753..5080854 + 102 Protein_4798 IS200/IS605 family transposase -
D5082_RS25295 5080871..5081155 - 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D5082_RS25300 5081145..5081393 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D5082_RS25305 5081684..5083483 + 1800 WP_043907032.1 ATP-dependent helicase -
D5082_RS25310 5083817..5084803 + 987 WP_040120328.1 hypothetical protein -
D5082_RS25315 5084948..5085301 + 354 WP_004181774.1 hypothetical protein -
D5082_RS25320 5085363..5086184 + 822 WP_004181772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T32045 WP_038991638.1 NZ_AP018750:c5081155-5080871 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T32045 NZ_AP018750:c5081155-5080871 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT32045 WP_004181777.1 NZ_AP018750:c5081393-5081145 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT32045 NZ_AP018750:c5081393-5081145 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References