Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1621344..1621924 Replicon chromosome
Accession NZ_AP018738
Organism Ferriphaselus amnicola strain OYT1

Toxin (Protein)


Gene name mazF Uniprot ID A0A2Z6GC71
Locus tag OYT1_RS08145 Protein ID WP_062627772.1
Coordinates 1621344..1621682 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2Z6GCU6
Locus tag OYT1_RS08150 Protein ID WP_062627771.1
Coordinates 1621682..1621924 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OYT1_RS08120 1617098..1618342 + 1245 WP_197714074.1 site-specific integrase -
OYT1_RS08125 1618396..1618776 - 381 WP_084612094.1 HNH endonuclease -
OYT1_RS08130 1618974..1620245 - 1272 WP_062627775.1 Y-family DNA polymerase -
OYT1_RS08135 1620253..1620696 - 444 WP_062627774.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
OYT1_RS08145 1621344..1621682 - 339 WP_062627772.1 endoribonuclease MazF Toxin
OYT1_RS08150 1621682..1621924 - 243 WP_062627771.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OYT1_RS08160 1622451..1622892 - 442 Protein_1602 putative toxin-antitoxin system toxin component, PIN family -
OYT1_RS08165 1622879..1623154 - 276 WP_062627769.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
OYT1_RS08175 1623688..1625637 - 1950 WP_062627768.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1562116..1627939 65823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-109)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12078.96 Da        Isoelectric Point: 8.5196

>T32007 WP_062627772.1 NZ_AP018738:c1621682-1621344 [Ferriphaselus amnicola]
MVSRFVPEAGDIVWLEFSPQAGHEQAGHRPALVLSSASYNGKTGTMLCCPMTTQIKGYPFEVIIHAKGVSGAVLSDQVKN
LDWRARKATPKGKATVEELDEVRAKISALLGL

Download         Length: 339 bp

>T32007 NZ_AP018738:c1621682-1621344 [Ferriphaselus amnicola]
ATGGTCTCTAGGTTTGTGCCAGAAGCTGGCGACATAGTCTGGCTTGAGTTCTCGCCACAGGCAGGGCACGAGCAGGCTGG
ACATCGCCCCGCATTGGTATTGAGTTCTGCATCCTATAACGGAAAAACCGGCACCATGTTGTGCTGTCCAATGACTACTC
AGATCAAAGGCTACCCGTTTGAGGTTATCATTCATGCAAAGGGTGTCAGCGGCGCGGTGCTGTCTGACCAAGTGAAGAAT
CTTGACTGGCGTGCACGTAAAGCAACACCGAAAGGAAAAGCCACTGTCGAAGAGTTAGACGAGGTACGCGCGAAAATCTC
TGCGCTGCTCGGTTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8905.43 Da        Isoelectric Point: 6.7256

>AT32007 WP_062627771.1 NZ_AP018738:c1621924-1621682 [Ferriphaselus amnicola]
MEVIVKKWGNSAAVRIPAAIMLAAHVDLDQSVDVREEQGRIVIEPVRRKVFKLEELLGGITEKNLHHLVDAGVPVGKEVW

Download         Length: 243 bp

>AT32007 NZ_AP018738:c1621924-1621682 [Ferriphaselus amnicola]
ATGGAAGTCATCGTAAAGAAGTGGGGTAACAGCGCTGCGGTTCGCATACCGGCGGCTATCATGCTGGCAGCACATGTTGA
CTTAGATCAGTCGGTCGATGTCCGTGAAGAGCAGGGGCGTATCGTCATCGAGCCAGTGCGACGCAAAGTATTCAAATTGG
AGGAGCTGCTGGGTGGCATTACAGAGAAAAACCTTCATCACCTAGTTGATGCGGGAGTTCCAGTGGGCAAGGAGGTCTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6GC71

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z6GCU6

References