Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/RelE(toxin)
Location 3106856..3107550 Replicon chromosome
Accession NZ_AP018724
Organism Sulfurivermis fontis strain JG42

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EP379_RS15595 Protein ID WP_127478653.1
Coordinates 3107290..3107550 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EP379_RS15590 Protein ID WP_127478652.1
Coordinates 3106856..3107188 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP379_RS15565 3103018..3103911 - 894 WP_127478647.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EP379_RS15570 3104210..3105160 + 951 WP_127478648.1 LysR family transcriptional regulator -
EP379_RS15575 3105205..3105618 - 414 WP_127478649.1 hypothetical protein -
EP379_RS15580 3105620..3105964 - 345 WP_127478650.1 hypothetical protein -
EP379_RS15585 3106227..3106679 + 453 WP_197722941.1 DUF411 domain-containing protein -
EP379_RS15590 3106856..3107188 - 333 WP_127478652.1 helix-turn-helix domain-containing protein Antitoxin
EP379_RS15595 3107290..3107550 - 261 WP_127478653.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EP379_RS15600 3107531..3107737 - 207 WP_127478654.1 hypothetical protein -
EP379_RS15605 3107924..3109162 + 1239 WP_127474685.1 ISL3 family transposase -
EP379_RS15610 3109247..3110311 - 1065 WP_127478655.1 fructose-bisphosphate aldolase class II -
EP379_RS15615 3110504..3111937 - 1434 WP_127478656.1 pyruvate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-85)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-90)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10050.71 Da        Isoelectric Point: 9.7615

>T32002 WP_127478653.1 NZ_AP018724:c3107550-3107290 [Sulfurivermis fontis]
MVSYRIEWKRSAEKELRRLPREVIPRIVEAVSGLGANPIPQNCRKLVGSECSYRICIGDYRVIYALYQDRLIVEVVRAGH
RSEVYR

Download         Length: 261 bp

>T32002 NZ_AP018724:c3107550-3107290 [Sulfurivermis fontis]
ATGGTCTCCTACAGGATTGAATGGAAGAGAAGTGCGGAGAAGGAGCTTCGCAGATTACCCCGCGAAGTTATTCCCCGCAT
CGTTGAGGCCGTTAGTGGCCTCGGCGCAAATCCAATACCTCAAAATTGCCGCAAGCTTGTCGGCAGCGAATGCAGTTACC
GTATCTGCATCGGAGATTACCGCGTCATTTATGCACTCTACCAAGATCGGCTGATTGTAGAGGTTGTGCGTGCGGGGCAC
AGAAGCGAAGTGTATAGATAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12661.58 Da        Isoelectric Point: 10.8957

>AT32002 WP_127478652.1 NZ_AP018724:c3107188-3106856 [Sulfurivermis fontis]
MSKNRKLFDEMVSGIDAMRQQREGKITLRTHEVDELPRPEIAPELIRATREQLHVSRAVFARRLRVSTRTLENWEQGRAK
PNAQAAALILMVRKYPDTLARLEQLNGEAA

Download         Length: 333 bp

>AT32002 NZ_AP018724:c3107188-3106856 [Sulfurivermis fontis]
ATGAGCAAGAACCGCAAGCTGTTCGACGAGATGGTGAGCGGCATCGATGCGATGCGCCAACAGCGCGAAGGAAAGATCAC
GTTGCGTACCCATGAAGTGGACGAATTGCCGCGCCCAGAGATCGCTCCGGAACTTATCCGCGCCACGCGCGAACAACTGC
ATGTTTCGCGGGCTGTATTTGCTCGGCGTTTGCGCGTTTCCACCCGGACACTTGAGAACTGGGAGCAGGGGCGGGCCAAA
CCCAACGCCCAGGCGGCAGCGTTGATTTTGATGGTGCGCAAGTACCCGGACACGTTGGCTCGATTGGAGCAGTTGAATGG
CGAAGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References