32001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-couple_hipB
Location 3024974..3025626 Replicon chromosome
Accession NZ_AP018724
Organism Sulfurivermis fontis strain JG42

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EP379_RS15155 Protein ID WP_127478572.1
Coordinates 3024974..3025231 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EP379_RS15160 Protein ID WP_127478573.1
Coordinates 3025228..3025626 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP379_RS15125 3020013..3020213 - 201 WP_127478566.1 hypothetical protein -
EP379_RS15130 3020285..3020878 - 594 WP_127478567.1 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase -
EP379_RS15135 3021072..3021788 - 717 WP_127478568.1 ribonuclease PH -
EP379_RS15140 3022091..3022987 - 897 WP_127478569.1 protein phosphatase 2C domain-containing protein -
EP379_RS15145 3023005..3023973 - 969 WP_127478570.1 serine/threonine protein kinase -
EP379_RS15150 3024068..3024931 + 864 WP_127478571.1 YicC family protein -
EP379_RS15155 3024974..3025231 + 258 WP_127478572.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EP379_RS15160 3025228..3025626 + 399 WP_127478573.1 helix-turn-helix domain-containing protein Antitoxin
EP379_RS15165 3025650..3026276 + 627 WP_127478574.1 guanylate kinase -
EP379_RS15170 3026521..3026790 + 270 WP_127478575.1 DNA-directed RNA polymerase subunit omega -
EP379_RS15175 3026813..3028924 + 2112 WP_127478576.1 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase -
EP379_RS15180 3028956..3030359 - 1404 WP_127478577.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-79)

Antitoxin

Cro/C1-type helix-turn-helix domain

(71-125)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9541.19 Da        Isoelectric Point: 9.8756

>T32001 WP_127478572.1 NZ_AP018724:3024974-3025231 [Sulfurivermis fontis]
MLQLVYKKAALKELAEMPAPVRRKMQEELAAIAANPHGYSGDWRPLTGSPYWRLRVGGYRAICHIQDEALVLLVLRAGPR
GDIDK

Download         Length: 258 bp

>T32001 NZ_AP018724:3024974-3025231 [Sulfurivermis fontis]
ATGCTCCAACTGGTATACAAGAAGGCCGCTCTGAAGGAACTGGCAGAGATGCCGGCCCCGGTACGCCGGAAGATGCAGGA
AGAACTGGCGGCGATCGCCGCCAATCCGCATGGCTATAGTGGCGACTGGAGGCCGCTGACCGGTTCACCCTATTGGCGCC
TGCGGGTGGGTGGCTACCGCGCCATCTGCCATATCCAGGACGAGGCGCTGGTATTGCTGGTGCTGAGGGCCGGGCCGCGA
GGGGACATCGACAAATGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14454.47 Da        Isoelectric Point: 4.8029

>AT32001 WP_127478573.1 NZ_AP018724:3025228-3025626 [Sulfurivermis fontis]
MSAQVQIIEKDGKPEYAVVPIELYRQLLTLAEDAEDLRAANAALRELENGADEAVPAEVAQRLLAGTEHPLRIWREHRGL
TQEALAAQAGVGKSYLSQIEAGKKTGSARTLRTLAQILRVEMNDLLMPPAQD

Download         Length: 399 bp

>AT32001 NZ_AP018724:3025228-3025626 [Sulfurivermis fontis]
ATGAGCGCACAGGTCCAGATCATCGAGAAGGACGGCAAACCCGAATATGCCGTCGTACCCATCGAACTGTACCGCCAATT
GCTGACCCTGGCGGAAGACGCCGAGGACCTCCGCGCCGCCAATGCCGCCCTGCGCGAACTGGAGAACGGTGCAGACGAGG
CGGTCCCGGCGGAAGTGGCACAGCGCCTGCTGGCCGGGACCGAACACCCGCTGCGCATCTGGCGCGAGCACCGCGGCCTG
ACTCAGGAGGCCCTCGCGGCCCAGGCCGGTGTCGGCAAATCCTATCTGTCGCAGATCGAGGCCGGTAAAAAGACCGGTTC
GGCCAGAACACTGCGTACCCTGGCGCAAATACTGCGGGTGGAGATGAACGATCTGCTCATGCCGCCCGCGCAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References