Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2877441..2878198 Replicon chromosome
Accession NZ_AP018724
Organism Sulfurivermis fontis strain JG42

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EP379_RS14375 Protein ID WP_127478462.1
Coordinates 2877441..2877935 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag EP379_RS14380 Protein ID WP_127478463.1
Coordinates 2877932..2878198 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP379_RS14355 2872631..2874304 - 1674 WP_127478458.1 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase -
EP379_RS14360 2874301..2875644 - 1344 WP_127478459.1 isochorismate synthase -
EP379_RS14365 2875644..2876543 - 900 WP_127478460.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
EP379_RS14370 2876540..2876953 - 414 WP_127478461.1 acyl-CoA thioesterase -
EP379_RS14375 2877441..2877935 - 495 WP_127478462.1 GNAT family N-acetyltransferase Toxin
EP379_RS14380 2877932..2878198 - 267 WP_127478463.1 DUF1778 domain-containing protein Antitoxin
EP379_RS14385 2878288..2878658 - 371 Protein_2830 excisionase family DNA-binding protein -
EP379_RS14390 2878637..2879764 + 1128 WP_127478464.1 Fic family protein -
EP379_RS14395 2879845..2880003 + 159 Protein_2832 DNA-binding protein -
EP379_RS14400 2880575..2881429 - 855 WP_127478465.1 hypothetical protein -
EP379_RS14405 2881446..2882120 - 675 WP_127478466.1 helix-turn-helix domain-containing protein -
EP379_RS14410 2882111..2882923 - 813 WP_127478942.1 TIGR04255 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(53-151)

Antitoxin

Vibrio phage ICP1, Orf50

(3-87)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17991.56 Da        Isoelectric Point: 9.9792

>T32000 WP_127478462.1 NZ_AP018724:c2877935-2877441 [Sulfurivermis fontis]
MSARLSAPQPLTAAHRLDDFSCGEPALDEWLKRRAMVNQQSGASRTFVVVDQDDRVQGYYAMAAGAVAHRLATGAVRRNM
PDPVPVLVLARLAVDTRAQGQKLGGAMLQDAVQRAVVVSQNAGVRALLVHALHDRARQFYEHYGFQTSPTEPFTLMLRLD
ATRP

Download         Length: 495 bp

>T32000 NZ_AP018724:c2877935-2877441 [Sulfurivermis fontis]
ATGAGTGCACGCTTAAGCGCGCCTCAACCGCTGACCGCTGCCCACCGTCTTGACGACTTTTCCTGCGGCGAGCCAGCACT
TGATGAGTGGCTCAAACGCCGGGCGATGGTCAATCAGCAAAGCGGCGCCAGTCGCACATTCGTCGTCGTGGATCAGGACG
ACCGCGTTCAGGGGTACTACGCGATGGCCGCGGGGGCGGTCGCACACCGTCTGGCTACCGGCGCAGTTCGCCGCAACATG
CCGGACCCCGTTCCGGTCTTGGTGCTGGCCCGGCTGGCCGTCGACACCCGCGCCCAGGGGCAAAAGCTGGGCGGGGCTAT
GCTTCAGGATGCCGTTCAACGGGCGGTGGTGGTCTCGCAGAACGCCGGCGTCCGGGCGCTACTCGTCCATGCCCTTCATG
ATCGCGCGAGGCAGTTCTACGAGCACTACGGCTTCCAGACATCGCCGACCGAGCCGTTCACACTGATGCTGCGGTTGGAT
GCCACCCGGCCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9907.47 Da        Isoelectric Point: 4.7265

>AT32000 WP_127478463.1 NZ_AP018724:c2878198-2877932 [Sulfurivermis fontis]
MRDAAINLRALPEQRALIDRAAQLLGKNRSDFMLEAACDKAQAVLLDQVYFNLDADKFQQFIDLLDAPPAPNPGLERLMA
LRAPWVKE

Download         Length: 267 bp

>AT32000 NZ_AP018724:c2878198-2877932 [Sulfurivermis fontis]
ATGCGTGACGCCGCCATCAACCTGCGGGCATTGCCTGAGCAGCGCGCTCTGATCGACCGTGCCGCCCAGCTCCTGGGCAA
GAACCGTTCGGATTTCATGCTCGAGGCCGCCTGCGACAAGGCTCAGGCGGTGCTGCTGGATCAGGTTTACTTCAACCTCG
ACGCCGACAAGTTTCAGCAGTTCATTGACCTGCTCGACGCACCGCCCGCGCCCAATCCAGGCCTTGAACGGCTGATGGCG
CTGAGGGCCCCGTGGGTCAAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References