Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2442525..2443175 Replicon chromosome
Accession NZ_AP018724
Organism Sulfurivermis fontis strain JG42

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EP379_RS12330 Protein ID WP_127478919.1
Coordinates 2442525..2442815 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag EP379_RS12335 Protein ID WP_127478094.1
Coordinates 2442825..2443175 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP379_RS12315 2437908..2438627 + 720 WP_127478091.1 ABC transporter ATP-binding protein -
EP379_RS12320 2438632..2440995 + 2364 WP_127478092.1 ABC transporter permease -
EP379_RS12325 2440992..2442182 + 1191 WP_127478093.1 efflux RND transporter periplasmic adaptor subunit -
EP379_RS12330 2442525..2442815 + 291 WP_127478919.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EP379_RS12335 2442825..2443175 + 351 WP_127478094.1 putative addiction module antidote protein Antitoxin
EP379_RS12340 2443216..2443551 + 336 WP_127478095.1 hypothetical protein -
EP379_RS12345 2444227..2444943 - 717 WP_127478096.1 phosphate signaling complex protein PhoU -
EP379_RS12350 2445204..2446058 - 855 WP_127478920.1 phosphate ABC transporter ATP-binding protein -
EP379_RS12355 2446111..2447775 - 1665 WP_127478921.1 phosphate ABC transporter permease PstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(6-94)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10803.41 Da        Isoelectric Point: 10.2301

>T31999 WP_127478919.1 NZ_AP018724:2442525-2442815 [Sulfurivermis fontis]
MMEIRKTDVYAKWLDGLRDIRARARILARVERLAEGNAGDAEPIGEGVSELRINYGPGYRVYYKQQGRELVILLAGGDKG
SQSRDIKTALRLARNL

Download         Length: 291 bp

>T31999 NZ_AP018724:2442525-2442815 [Sulfurivermis fontis]
ATGATGGAGATTCGCAAAACGGATGTCTATGCCAAGTGGCTCGATGGCCTGCGGGACATTCGGGCTCGTGCCCGTATTCT
CGCGAGAGTTGAACGCTTGGCTGAAGGAAATGCAGGAGACGCCGAACCCATCGGAGAAGGAGTCTCTGAGTTGCGAATCA
ACTATGGCCCCGGCTACCGGGTCTACTACAAACAGCAAGGAAGAGAGCTGGTGATCTTGTTGGCTGGCGGTGATAAGGGC
AGTCAATCAAGAGACATCAAGACGGCTCTACGGCTTGCTCGTAATCTGTAG

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 12350.85 Da        Isoelectric Point: 6.4830

>AT31999 WP_127478094.1 NZ_AP018724:2442825-2443175 [Sulfurivermis fontis]
VKKTATSRYDVAEHLRTPEEMAAYLEACLEEADGDAAFIAKALGDIARAKGMSQVARDAGVSRESLYKALSGERAPSFDT
ILKVVGALGLRFHAEAAHIQDHAQQGAPTDARPSRG

Download         Length: 351 bp

>AT31999 NZ_AP018724:2442825-2443175 [Sulfurivermis fontis]
GTGAAAAAGACAGCAACTTCCCGCTACGACGTTGCCGAGCATCTGCGCACTCCCGAAGAAATGGCTGCTTATCTGGAAGC
ATGCTTAGAAGAGGCGGATGGTGATGCTGCGTTTATAGCAAAGGCCCTCGGAGACATTGCGCGCGCTAAAGGCATGTCTC
AAGTGGCACGCGATGCAGGTGTGTCACGTGAAAGCCTGTACAAGGCGCTCTCCGGCGAAAGAGCCCCAAGCTTCGACACC
ATTCTGAAAGTCGTTGGCGCACTCGGTCTGAGGTTTCATGCCGAAGCAGCACATATCCAAGACCATGCCCAACAAGGCGC
TCCAACCGACGCTCGTCCATCGCGCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References