Detailed information of TA system TA031998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-copA/RelE-RHH
• Location: 2230112..2230634
• Replicon: chromosome
• Accession: NZ_AP018724
• Organism: Sulfurivermis fontis strain JG42

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EP379_RS11310
• Protein ID: WP_127477907.1
• Coordinates: 2230112..2230402 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: EP379_RS11315
• Protein ID: WP_127477908.1
• Coordinates: 2230392..2230634 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EP379_RS11275	2225458..2226768	-	1311	WP_127477900.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EP379_RS11280	2226820..2227077	-	258	WP_127477901.1	BolA family transcriptional regulator	-
EP379_RS11285	2227211..2227510	-	300	WP_127477902.1	STAS domain-containing protein	-
EP379_RS11290	2227507..2227977	-	471	WP_197722922.1	outer membrane lipid asymmetry maintenance protein MlaD	-
EP379_RS11295	2227974..2228756	-	783	WP_127477904.1	lipid asymmetry maintenance ABC transporter permease subunit MlaE	-
EP379_RS11300	2228756..2229580	-	825	WP_127477905.1	ABC transporter ATP-binding protein	-
EP379_RS11305	2229657..2230106	-	450	WP_172600456.1	DUF72 domain-containing protein	-
EP379_RS11310	2230112..2230402	-	291	WP_127477907.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EP379_RS11315	2230392..2230634	-	243	WP_127477908.1	CopG family ribbon-helix-helix protein	Antitoxin
EP379_RS11320	2230743..2230928	+	186	WP_127478906.1	hypothetical protein	-
EP379_RS11325	2231012..2231758	+	747	WP_197722779.1	VacJ family lipoprotein	-
EP379_RS11330	2231970..2232962	+	993	WP_127477909.1	calcium/sodium antiporter	-
EP379_RS11335	2232975..2233175	+	201	WP_127477910.1	heavy-metal-associated domain-containing protein	-
EP379_RS11340	2233172..2234158	+	987	WP_127477911.1	KpsF/GutQ family sugar-phosphate isomerase	-
EP379_RS11345	2234299..2234823	+	525	WP_127477912.1	3-deoxy-manno-octulosonate-8-phosphatase KdsC	-
EP379_RS11350	2234820..2235383	+	564	WP_172600457.1	LPS export ABC transporter periplasmic protein LptC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11295.21 Da
• Isoelectric Point: 11.7506

>T31998 WP_127477907.1 NZ_AP018724:c2230402-2230112 [Sulfurivermis fontis]
MEIRWLRKALGNLEQEASYVAREDPAAARMVVQRIWQAVSLLAENPALGQPGRIHGTRELVINRRRYLIPYRVNPRLQCI
EILRVFHASRKPPQRW

Nucleotide

• Length: 291 bp

>T31998 NZ_AP018724:c2230402-2230112 [Sulfurivermis fontis]
ATGGAGATTAGATGGCTGCGCAAGGCGCTTGGCAATCTTGAGCAGGAAGCCTCTTACGTTGCCCGCGAGGATCCGGCGGC
TGCGCGCATGGTGGTGCAACGCATTTGGCAGGCGGTCAGCCTGTTGGCGGAGAACCCGGCGCTGGGACAACCCGGTCGCA
TCCACGGTACCCGCGAATTGGTGATCAACCGGAGGCGTTACCTTATCCCCTATCGCGTGAATCCGCGCCTGCAATGCATC
GAAATCCTGCGCGTGTTTCATGCCTCCCGCAAGCCGCCGCAACGCTGGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8955.95 Da
• Isoelectric Point: 4.2808

>AT31998 WP_127477908.1 NZ_AP018724:c2230634-2230392 [Sulfurivermis fontis]
MSTTMTVRLEPDLKERLEHLAAATHRSKSFLAAEAIREFVELNEWQIREIQAALQEADAGDFASAEEVNDVLGRWGVNGD

Nucleotide

• Length: 243 bp

>AT31998 NZ_AP018724:c2230634-2230392 [Sulfurivermis fontis]
ATGTCTACGACGATGACCGTCCGATTGGAACCCGATTTGAAGGAGCGGCTGGAACACTTGGCGGCGGCGACCCACCGTTC
CAAATCGTTTTTGGCCGCCGAAGCGATACGTGAGTTCGTTGAACTGAACGAATGGCAGATCCGGGAGATCCAGGCCGCTT
TGCAGGAGGCGGATGCGGGGGACTTCGCTTCGGCAGAGGAGGTCAATGACGTGCTTGGGCGGTGGGGCGTGAATGGAGAT
TAG