31997

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 1050403..1051925 Replicon chromosome
Accession NZ_AP018724
Organism Sulfurivermis fontis strain JG42

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag EP379_RS05490 Protein ID WP_185974921.1
Coordinates 1050403..1051329 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag EP379_RS05495 Protein ID WP_127478838.1
Coordinates 1051326..1051925 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP379_RS05450 1045480..1045806 + 327 WP_102042177.1 helix-turn-helix domain-containing protein -
EP379_RS05455 1045796..1046689 + 894 WP_102042176.1 ImmA/IrrE family metallo-endopeptidase -
EP379_RS05460 1046807..1047025 + 219 WP_072755421.1 hypothetical protein -
EP379_RS05465 1047022..1047519 + 498 WP_072755420.1 DUF2924 domain-containing protein -
EP379_RS05470 1047516..1048874 + 1359 WP_072755419.1 recombinase family protein -
EP379_RS05475 1048871..1049302 + 432 WP_102042175.1 hypothetical protein -
EP379_RS05480 1049334..1049921 - 588 WP_024892249.1 hypothetical protein -
EP379_RS05485 1049918..1050406 - 489 WP_024892248.1 hypothetical protein -
EP379_RS05490 1050403..1051329 - 927 WP_185974921.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EP379_RS05495 1051326..1051925 - 600 WP_127478838.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
EP379_RS05500 1052375..1053193 + 819 WP_127476615.1 ParA family protein -
EP379_RS16340 1053195..1053509 + 315 WP_172600385.1 hypothetical protein -
EP379_RS16345 1053506..1053733 + 228 WP_172600386.1 hypothetical protein -
EP379_RS05505 1053730..1055388 + 1659 WP_172600387.1 ParB N-terminal domain-containing protein -
EP379_RS05510 1055392..1056012 + 621 WP_127476620.1 DUF2857 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 982235..1074487 92252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-259)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(8-53)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 34681.53 Da        Isoelectric Point: 5.6877

>T31997 WP_185974921.1 NZ_AP018724:c1051329-1050403 [Sulfurivermis fontis]
MNQRNMAASVRARLLNRARETRQDFNLILTRYALERLLYRLSISPHADQFLLKGALLFDLWFDIPHRPTRDADLLGFGSA
EIPHVEAAFRDICTVELDDGIRFQPDSVHAEEIRKEANYSGVRVTLIGLLDGARCHVQVDVGFGDAVTPGPEAVDYPVML
PDMPAPKLRAYPRYTVVAEKLEALVSLGIANSRMKDYFDLWILSRYTDFDGALLCKAIHATFERRRTPLPDGVPFGLSDE
FAQDRQKQTQWQAFLRKNALDELQLSEVVAGLRAFLSFPLDALQQGAAFPQTWLAGNGWMSSGEESGR

Download         Length: 927 bp

>T31997 NZ_AP018724:c1051329-1050403 [Sulfurivermis fontis]
ATGAACCAGCGCAACATGGCCGCCTCGGTGCGCGCCCGCCTGCTCAACCGCGCCCGCGAGACCCGACAAGACTTCAATCT
GATCTTGACCCGCTATGCGCTTGAGCGCCTGCTTTACCGGCTCAGCATCTCCCCCCACGCCGACCAGTTCCTGCTGAAAG
GTGCGCTGCTGTTCGACTTGTGGTTCGACATCCCGCATCGTCCGACACGCGACGCCGATCTGCTGGGCTTCGGCTCGGCC
GAGATCCCGCATGTCGAGGCGGCGTTTCGGGACATCTGTACGGTGGAACTGGACGACGGCATACGCTTCCAGCCTGACTC
GGTACACGCGGAGGAGATCCGCAAGGAAGCCAACTACTCCGGTGTCCGGGTCACGCTGATCGGCCTGTTGGACGGTGCCC
GATGCCACGTGCAGGTCGACGTGGGTTTCGGCGACGCCGTGACGCCCGGCCCCGAGGCCGTCGACTACCCGGTAATGCTG
CCGGACATGCCAGCCCCGAAGCTGCGCGCCTACCCCCGCTACACGGTTGTCGCCGAGAAGCTGGAGGCACTGGTGTCGCT
CGGCATCGCCAACAGCCGCATGAAGGATTACTTCGATCTCTGGATCTTGTCGCGCTACACCGACTTCGACGGCGCGCTCC
TGTGCAAGGCGATCCACGCCACCTTCGAGCGCCGCAGGACACCGCTGCCGGATGGCGTCCCTTTCGGATTGAGCGACGAA
TTCGCGCAGGATCGGCAGAAGCAGACTCAGTGGCAAGCATTCTTGAGGAAGAATGCCTTGGACGAGCTTCAGCTTTCCGA
GGTCGTTGCCGGTCTGCGTGCCTTCCTGTCATTCCCGCTGGACGCGCTCCAGCAAGGTGCTGCATTTCCGCAAACATGGC
TTGCCGGAAACGGGTGGATGTCGAGCGGCGAGGAATCGGGCCGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22292.93 Da        Isoelectric Point: 9.9677

>AT31997 WP_127478838.1 NZ_AP018724:c1051925-1051326 [Sulfurivermis fontis]
MDSSHQSILDLAAQRGLIRPRDLNERGLPTIALTRLVRQGLLQRVGRGLYAIPDRAVSEHGALSEVARKHPQAIVCLLSA
LRLHELTTQSPFEVWLAIPNKARAPKMDYPPLHIVRFSGAALTEGVEEHLIDGVPVRVTNVARTVADCFKFRNKIGLDVA
LEALQESWRAKRVSMDELWRFAALCRVANVMRPYMESLS

Download         Length: 600 bp

>AT31997 NZ_AP018724:c1051925-1051326 [Sulfurivermis fontis]
ATGGACAGTTCGCACCAGAGCATTCTGGATCTTGCCGCCCAGCGCGGCCTTATTCGCCCACGCGATCTCAATGAGCGTGG
GCTGCCCACGATCGCCCTCACGCGGCTGGTGCGGCAAGGGCTGCTCCAGCGCGTGGGACGGGGCCTGTACGCAATTCCGG
ACCGGGCCGTCTCGGAACACGGCGCACTCTCCGAGGTGGCACGCAAGCACCCGCAAGCCATCGTCTGCCTGCTGTCGGCA
CTGCGCCTACATGAACTCACCACACAGTCGCCGTTCGAGGTCTGGCTGGCAATTCCCAACAAGGCACGCGCGCCAAAGAT
GGACTATCCCCCGCTGCACATCGTGCGCTTCTCTGGCGCCGCGCTGACGGAGGGGGTCGAGGAGCACCTCATCGATGGTG
TGCCGGTGCGCGTGACCAACGTCGCCCGGACCGTGGCTGACTGCTTCAAGTTCCGCAACAAGATCGGCCTCGATGTCGCG
CTGGAGGCGCTACAGGAGTCCTGGCGTGCCAAGCGCGTCAGCATGGATGAACTTTGGCGTTTTGCTGCGCTGTGCCGTGT
GGCCAATGTGATGCGCCCCTACATGGAAAGCCTGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References