31996

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1016646..1017322 Replicon chromosome
Accession NZ_AP018724
Organism Sulfurivermis fontis strain JG42

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EP379_RS05255 Protein ID WP_127476551.1
Coordinates 1016894..1017322 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EP379_RS05250 Protein ID WP_127476549.1
Coordinates 1016646..1016897 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP379_RS05245 1013613..1016543 - 2931 WP_127476546.1 hypothetical protein -
EP379_RS05250 1016646..1016897 + 252 WP_127476549.1 Arc family DNA-binding protein Antitoxin
EP379_RS05255 1016894..1017322 + 429 WP_127476551.1 type II toxin-antitoxin system VapC family toxin Toxin
EP379_RS05260 1017380..1018021 - 642 WP_127476553.1 hypothetical protein -
EP379_RS16335 1018018..1018155 - 138 WP_172600383.1 hypothetical protein -
EP379_RS05265 1018167..1018586 - 420 WP_197722863.1 hypothetical protein -
EP379_RS05270 1018592..1019347 - 756 WP_127476556.1 hypothetical protein -
EP379_RS05275 1019354..1019551 - 198 WP_127476558.1 hypothetical protein -
EP379_RS05280 1019553..1019981 - 429 WP_172600384.1 hypothetical protein -
EP379_RS05285 1019978..1020262 - 285 WP_127476561.1 hypothetical protein -
EP379_RS05290 1020262..1021266 - 1005 WP_127476563.1 major capsid protein -
EP379_RS05295 1021330..1021707 - 378 WP_127476565.1 head decoration protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 982235..1074487 92252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15232.76 Da        Isoelectric Point: 7.2038

>T31996 WP_127476551.1 NZ_AP018724:1016894-1017322 [Sulfurivermis fontis]
MILLDTNLISEPLRAAPEPRVVAWLDAQPLETLFLSVVTVAELRYGVARLPNGRRRKILAEHLETQVLPAFATRILAFDL
PATQVYADLMAKAQAAGQPIGMADGLIAAIARTHGMRVATRDTAPFAAAGVPVINPWSEGSP

Download         Length: 429 bp

>T31996 NZ_AP018724:1016894-1017322 [Sulfurivermis fontis]
ATGATCCTCCTGGACACCAACCTCATCTCCGAGCCGCTACGCGCCGCGCCTGAACCGCGCGTCGTCGCCTGGCTCGACGC
CCAGCCGCTGGAGACGCTGTTCCTGTCCGTCGTCACCGTGGCCGAGTTGCGCTACGGGGTGGCCCGCCTGCCCAACGGTC
GCCGGCGCAAGATCCTCGCCGAACACCTGGAGACCCAGGTGCTGCCCGCCTTCGCCACCCGCATACTGGCCTTCGACCTG
CCGGCGACCCAGGTTTACGCCGACCTGATGGCCAAGGCGCAGGCCGCCGGACAGCCCATCGGCATGGCCGATGGATTGAT
CGCGGCGATTGCCCGGACCCATGGCATGAGGGTCGCCACACGCGACACGGCGCCGTTCGCCGCGGCGGGTGTTCCCGTCA
TCAATCCGTGGTCGGAGGGATCGCCGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9236.68 Da        Isoelectric Point: 10.2845

>AT31996 WP_127476549.1 NZ_AP018724:1016646-1016897 [Sulfurivermis fontis]
MAILTVRNLPDEVHRALRLSAAKHGRSTEAEVRAILEEAVKPQGRLKLGSMLADIGRRLRLSDEELALINQRDKSAPRAV
DLE

Download         Length: 252 bp

>AT31996 NZ_AP018724:1016646-1016897 [Sulfurivermis fontis]
ATGGCCATCCTGACGGTTCGCAATCTGCCCGACGAGGTACATCGCGCCTTGCGCCTGAGCGCGGCCAAGCATGGGCGCAG
CACCGAGGCAGAGGTGCGCGCCATCCTGGAAGAGGCAGTGAAGCCGCAAGGGCGGCTGAAGCTGGGCTCGATGCTGGCCG
ACATCGGCCGGCGCCTCCGGCTCAGCGACGAGGAGCTCGCATTGATCAATCAGCGCGACAAGTCGGCCCCACGGGCGGTG
GATCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References