Detailed information of TA system TA031995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 980597..981375
• Replicon: chromosome
• Accession: NZ_AP018724
• Organism: Sulfurivermis fontis strain JG42

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: EP379_RS05075
• Protein ID: WP_127476488.1
• Coordinates: 980597..981100 (-)
• Length: 168 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: EP379_RS05080
• Protein ID: WP_127476490.1
• Coordinates: 981097..981375 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EP379_RS05035	976259..976531	-	273	WP_127476477.1	SRPBCC domain-containing protein	-
EP379_RS05040	976720..977073	+	354	Protein_982	hypothetical protein	-
EP379_RS05045	977070..978461	-	1392	Protein_983	mercury(II) reductase	-
EP379_RS05050	978517..978792	-	276	WP_127476482.1	mercury resistance system periplasmic binding protein MerP	-
EP379_RS05055	978806..979168	-	363	WP_127476484.1	mercuric ion transporter MerT	-
EP379_RS05060	979240..979647	+	408	WP_127476486.1	Hg(II)-responsive transcriptional regulator	-
EP379_RS16485	979679..980026	+	348	WP_197722860.1	hypothetical protein	-
EP379_RS05070	980023..980625	+	603	Protein_988	hypothetical protein	-
EP379_RS05075	980597..981100	-	504	WP_127476488.1	GNAT family N-acetyltransferase	Toxin
EP379_RS05080	981097..981375	-	279	WP_127476490.1	DUF1778 domain-containing protein	Antitoxin
EP379_RS05085	982235..983131	-	897	WP_172600382.1	LysR family transcriptional regulator	-
EP379_RS05090	983415..984023	+	609	WP_058130988.1	TetR/AcrR family transcriptional regulator	-
EP379_RS05095	984214..984639	+	426	WP_014819567.1	hypothetical protein	-
EP379_RS05100	984667..985707	+	1041	WP_127476495.1	secretion protein HlyD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (11-86)

Sequences

Toxin

Protein

• Length: 168 a.a.
• Molecular weight: 18444.19 Da
• Isoelectric Point: 6.8441

>T31995 WP_127476488.1 NZ_AP018724:c981100-980597 [Sulfurivermis fontis]
MNDGYTPVRKLLATDQVDAFDCGENALNQFLQRYALVNQKANSAQTYVCCQGDVVVGFYSLAVGSVDPEAAPSSVMKGLA
RHPVPVMILARLAVDKAHQRKGLGQALLKDALLRTAQAADIAGIRCLLVHAKDNAARQWYESWEFEPSPTDPYHLFLMLK
DLENLLR

Nucleotide

• Length: 504 bp

>T31995 NZ_AP018724:c981100-980597 [Sulfurivermis fontis]
TTGAACGATGGCTACACACCCGTTCGCAAGCTGCTTGCGACGGATCAGGTCGATGCTTTCGACTGCGGTGAGAATGCGCT
GAACCAGTTCCTGCAGCGCTACGCGCTCGTCAACCAAAAGGCCAACAGCGCGCAGACCTACGTCTGCTGCCAGGGCGACG
TGGTGGTCGGCTTCTACAGCCTCGCCGTCGGCAGTGTCGATCCGGAGGCCGCGCCGTCAAGCGTGATGAAGGGGCTGGCG
CGTCACCCGGTACCGGTCATGATCCTGGCCCGGCTCGCGGTGGACAAGGCGCATCAGCGCAAAGGACTGGGCCAGGCCTT
GCTCAAGGATGCGCTGCTGCGCACCGCACAGGCCGCCGACATCGCCGGCATTCGCTGCCTGCTGGTCCATGCCAAGGACA
ATGCGGCGCGGCAGTGGTATGAATCCTGGGAATTCGAGCCCAGTCCGACCGATCCGTATCATCTGTTTTTGATGCTCAAG
GATCTCGAGAATTTGCTGCGCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10252.84 Da
• Isoelectric Point: 10.4751

>AT31995 WP_127476490.1 NZ_AP018724:c981375-981097 [Sulfurivermis fontis]
MSTLNLSKTERIDVRASAPVKQLLQEAARACHKNVSEFLLDAGVTAAAQTLADRRRFVLDEAQWQAFQEALDRPVQAKPR
LKKLLREPGVLG

Nucleotide

• Length: 279 bp

>AT31995 NZ_AP018724:c981375-981097 [Sulfurivermis fontis]
ATGAGCACCCTGAATCTTTCCAAGACCGAACGCATTGACGTTCGCGCCAGTGCGCCAGTCAAGCAGCTGCTGCAGGAGGC
CGCGCGCGCCTGCCACAAGAACGTCAGCGAGTTTCTGCTCGACGCGGGCGTGACGGCGGCCGCGCAGACACTGGCGGATC
GTCGCCGGTTCGTGCTCGACGAGGCGCAGTGGCAGGCGTTCCAGGAAGCGCTGGATCGTCCGGTACAAGCCAAGCCGCGT
CTGAAGAAGTTGCTGCGTGAACCCGGGGTGCTGGGTTGA