Detailed information of TA system TA031992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1836324..1836834
• Replicon: chromosome
• Accession: NZ_AP018722
• Organism: Thiomicrorhabdus aquaedulcis strain HaS4

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EP181_RS08375
• Protein ID: WP_127471237.1
• Coordinates: 1836324..1836587 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EP181_RS08380
• Protein ID: WP_127471238.1
• Coordinates: 1836577..1836834 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EP181_RS08360	1832464..1834107	-	1644	WP_127471234.1	O-antigen ligase family protein	-
EP181_RS08365	1834177..1834689	-	513	WP_127471235.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
EP181_RS08370	1834826..1835929	-	1104	WP_127471236.1	HAMP domain-containing histidine kinase	-
EP181_RS08375	1836324..1836587	-	264	WP_127471237.1	Txe/YoeB family addiction module toxin	Toxin
EP181_RS08380	1836577..1836834	-	258	WP_127471238.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EP181_RS08385	1837105..1837737	-	633	WP_127471239.1	response regulator	-
EP181_RS08390	1837737..1839224	-	1488	WP_127471240.1	type II secretion system GspH family protein	-
EP181_RS08395	1839221..1840612	-	1392	WP_127471241.1	hypothetical protein	-
EP181_RS08400	1840614..1841495	-	882	WP_127471242.1	type II secretion system GspH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1807934..1931784	123850

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10445.84 Da
• Isoelectric Point: 7.9832

>T31992 WP_127471237.1 NZ_AP018722:c1836587-1836324 [Thiomicrorhabdus aquaedulcis]
MTIEILSWTEKAWSDYEYWQSQDKKTLRRINKLIQDTMRSPFEGIGKPEPLKENLSGFWSRRIDESNRLVYAVDSNQITV
IACRYHY

Nucleotide

• Length: 264 bp

>T31992 NZ_AP018722:c1836587-1836324 [Thiomicrorhabdus aquaedulcis]
ATGACGATTGAAATTCTGTCTTGGACAGAGAAAGCTTGGTCTGATTATGAATATTGGCAAAGCCAAGACAAGAAAACCTT
AAGGCGTATTAATAAGTTAATTCAAGATACCATGCGCTCACCATTTGAAGGGATTGGTAAACCAGAACCCTTAAAAGAAA
ATCTTTCAGGTTTTTGGTCAAGAAGAATAGATGAGTCTAATCGCCTTGTTTATGCGGTTGATTCAAACCAGATTACTGTC
ATTGCCTGCCGTTACCACTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9416.68 Da
• Isoelectric Point: 6.4725

>AT31992 WP_127471238.1 NZ_AP018722:c1836834-1836577 [Thiomicrorhabdus aquaedulcis]
MQVVSYTEARNSLKSVLDSVVDNADCAIITRRDAGNAVVMSLDYFNSLMETVHLLKSPSNAIHLKHSIEQYHSGKIVQKG
LLNDD

Nucleotide

• Length: 258 bp

>AT31992 NZ_AP018722:c1836834-1836577 [Thiomicrorhabdus aquaedulcis]
ATGCAAGTTGTAAGTTATACAGAAGCGAGAAACAGTTTAAAGTCTGTCTTGGATTCAGTCGTTGATAATGCCGATTGCGC
AATCATCACACGCAGAGACGCTGGTAATGCGGTTGTCATGTCACTGGATTACTTTAATAGCTTGATGGAAACTGTGCATT
TACTTAAATCCCCCTCAAATGCGATCCATTTAAAGCACTCTATTGAGCAATATCATTCAGGAAAAATCGTTCAAAAAGGG
CTGCTTAATGACGATTGA