Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 494849..495390 Replicon chromosome
Accession NZ_AP018722
Organism Thiomicrorhabdus aquaedulcis strain HaS4

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EP181_RS02160 Protein ID WP_127470197.1
Coordinates 494849..495157 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EP181_RS02165 Protein ID WP_127470198.1
Coordinates 495151..495390 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP181_RS02140 491017..491967 - 951 WP_172959665.1 acyltransferase family protein -
EP181_RS02145 492047..492376 - 330 WP_127470194.1 hypothetical protein -
EP181_RS02150 492373..493986 - 1614 WP_172959666.1 glycosyltransferase family 39 protein -
EP181_RS02155 494001..494738 - 738 WP_127470196.1 SDR family oxidoreductase -
EP181_RS02160 494849..495157 - 309 WP_127470197.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EP181_RS02165 495151..495390 - 240 WP_127470198.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EP181_RS02170 495565..496962 - 1398 WP_127470199.1 FAD-binding oxidoreductase -
EP181_RS02175 496959..497357 - 399 WP_127470200.1 GtrA family protein -
EP181_RS02180 497418..498308 + 891 WP_127470201.1 decaprenyl-phosphate phosphoribosyltransferase -
EP181_RS02185 498378..498851 + 474 WP_127470202.1 divergent PAP2 family protein -
EP181_RS02190 498851..499858 + 1008 WP_127470203.1 glycosyltransferase family 39 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-92)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11699.88 Da        Isoelectric Point: 10.1062

>T31990 WP_127470197.1 NZ_AP018722:c495157-494849 [Thiomicrorhabdus aquaedulcis]
MVARGEVYWVELDPTIGTEIKKTRPCLIISPDDMNRILPRVIIAPITSKSQALGCRPEVIFNDKKGRILLDQVRTVDKKR
LKNKMGEIPLSQWHDTLMQMLS

Download         Length: 309 bp

>T31990 NZ_AP018722:c495157-494849 [Thiomicrorhabdus aquaedulcis]
ATGGTAGCCAGGGGTGAAGTTTACTGGGTAGAATTGGATCCAACGATTGGCACCGAGATTAAAAAAACCCGCCCTTGTTT
AATTATTTCTCCAGACGATATGAATCGTATCTTACCACGCGTCATTATTGCGCCGATTACATCAAAAAGTCAGGCGTTAG
GCTGTCGACCAGAGGTCATTTTTAATGACAAAAAAGGGCGAATTCTCCTAGACCAAGTTCGAACGGTAGATAAAAAACGC
TTAAAAAATAAAATGGGAGAAATCCCTTTGAGCCAATGGCACGATACGTTAATGCAAATGCTGTCTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9277.42 Da        Isoelectric Point: 4.2690

>AT31990 WP_127470198.1 NZ_AP018722:c495390-495151 [Thiomicrorhabdus aquaedulcis]
MQTTLRKIGNSRGIIIPSSIIEQLHIDNEVEMEVQDGVLLLKPSNTPRKGWFDHYNPEKDIEPLSEMKDLESEQEDWQW

Download         Length: 240 bp

>AT31990 NZ_AP018722:c495390-495151 [Thiomicrorhabdus aquaedulcis]
ATGCAAACAACACTTCGCAAAATTGGCAATTCCCGTGGAATTATCATTCCATCTTCAATCATTGAGCAACTTCATATAGA
CAATGAAGTTGAAATGGAAGTTCAAGATGGTGTACTACTTTTAAAGCCATCTAATACGCCTAGAAAAGGGTGGTTTGATC
ATTACAACCCCGAGAAAGATATTGAGCCTTTATCAGAGATGAAAGACTTAGAAAGTGAACAAGAAGATTGGCAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References