Detailed information of TA system TA031986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 795055..795587
• Replicon: chromosome
• Accession: NZ_AP018721
• Organism: Sulfuritortus calidifontis strain J1A

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: EL388_RS04275
• Protein ID: WP_126460125.1
• Coordinates: 795055..795378 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: EL388_RS04280
• Protein ID: WP_126460128.1
• Coordinates: 795375..795587 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL388_RS04250	792112..792570	+	459	WP_126460113.1	CopD family protein	-
EL388_RS04255	792908..793159	+	252	WP_126460116.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EL388_RS04260	793156..793578	+	423	WP_126460119.1	type II toxin-antitoxin system VapC family toxin	-
EL388_RS04265	793648..794105	+	458	Protein_835	CopD family protein	-
EL388_RS13810	794588..794755	-	168	WP_165919155.1	hypothetical protein	-
EL388_RS04270	794752..794985	-	234	WP_126460122.1	addiction module protein	-
EL388_RS04275	795055..795378	-	324	WP_126460125.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
EL388_RS04280	795375..795587	-	213	WP_126460128.1	antitoxin MazE family protein	Antitoxin
EL388_RS04290	796213..796560	-	348	WP_165919154.1	MarR family transcriptional regulator	-
EL388_RS04295	796566..796859	-	294	WP_126460134.1	hypothetical protein	-
EL388_RS04300	796964..797194	-	231	WP_126463995.1	GIY-YIG nuclease family protein	-
EL388_RS04305	797216..797497	-	282	WP_126460138.1	type II toxin-antitoxin system HicA family toxin	-
EL388_RS04310	797681..799297	-	1617	WP_126460141.1	peptide chain release factor 3	-
EL388_RS04315	799432..800283	-	852	WP_126460144.1	GGDEF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	783461..796859	13398

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-105)

Antitoxin

• Antitoxin MazE-like (7-69)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11570.42 Da
• Isoelectric Point: 6.4639

>T31986 WP_126460125.1 NZ_AP018721:c795378-795055 [Sulfuritortus calidifontis]
VRRGDLVTVALQGDLGKPRPALVIQSDLFDAHPSVTILPVTSELRDAPLFRIALAPSDENGLSKPSQIMVDKPQSITREK
IGKVIGHLDDETMLAVNRALAVFLGFT

Nucleotide

• Length: 324 bp

>T31986 NZ_AP018721:c795378-795055 [Sulfuritortus calidifontis]
GTGAGGCGTGGTGATCTGGTCACGGTCGCCTTGCAAGGCGACCTGGGCAAACCACGCCCCGCCCTCGTCATCCAGTCCGA
TCTGTTCGACGCCCACCCATCCGTCACCATCCTGCCGGTCACCAGCGAACTACGCGATGCACCCTTGTTTCGCATTGCGC
TCGCACCCAGCGACGAAAACGGGCTGAGCAAACCTTCTCAGATCATGGTGGACAAACCGCAATCCATCACACGCGAGAAA
ATCGGCAAGGTCATCGGCCACCTGGATGATGAAACCATGCTGGCAGTCAATCGCGCCCTGGCAGTTTTCCTGGGCTTTAC
TTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8101.95 Da
• Isoelectric Point: 5.0892

>AT31986 WP_126460128.1 NZ_AP018721:c795587-795375 [Sulfuritortus calidifontis]
MATSTSERVQKHRDALRAAGLRPLQIWVPDTRRPGFAEECRRQSLALQDDAHEQETLEWLETAGDREGWQ

Nucleotide

• Length: 213 bp

>AT31986 NZ_AP018721:c795587-795375 [Sulfuritortus calidifontis]
ATGGCCACCAGCACATCCGAACGGGTGCAAAAGCACCGCGACGCGCTGCGCGCAGCCGGGCTGCGCCCCTTGCAGATTTG
GGTGCCCGATACCCGCCGCCCCGGCTTTGCCGAAGAATGCCGCCGGCAATCGCTGGCCTTACAAGACGATGCGCACGAAC
AGGAAACACTGGAATGGCTTGAAACCGCCGGCGACCGCGAGGGCTGGCAGTGA