Detailed information of TA system TA031984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2076260..2076963
• Replicon: chromosome
• Accession: NZ_AP018718
• Organism: Sulfuricystis multivorans strain J5B

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EL335_RS10375
• Protein ID: WP_126446655.1
• Coordinates: 2076260..2076706 (-)
• Length: 149 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EL335_RS10380
• Protein ID: WP_126446657.1
• Coordinates: 2076703..2076963 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL335_RS10350	2071339..2072802	-	1464	WP_126446645.1	hypothetical protein	-
EL335_RS10355	2072799..2073719	-	921	WP_126446647.1	glycosyltransferase family 10	-
EL335_RS10360	2073861..2074580	-	720	WP_126446649.1	FkbM family methyltransferase	-
EL335_RS10365	2074577..2075122	-	546	WP_126446651.1	methyltransferase domain-containing protein	-
EL335_RS10370	2075119..2076243	-	1125	WP_126446654.1	GDP-L-fucose synthase	-
EL335_RS10375	2076260..2076706	-	447	WP_126446655.1	type II toxin-antitoxin system VapC family toxin	Toxin
EL335_RS10380	2076703..2076963	-	261	WP_126446657.1	DUF2191 domain-containing protein	Antitoxin
EL335_RS10385	2077073..2078158	-	1086	WP_126446659.1	GDP-mannose 4,6-dehydratase	-
EL335_RS10390	2078340..2078888	-	549	WP_126446661.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-
EL335_RS10395	2078996..2079424	-	429	WP_126446663.1	DUF86 domain-containing protein	-
EL335_RS10400	2079417..2079845	-	429	WP_126446665.1	nucleotidyltransferase domain-containing protein	-
EL335_RS10405	2079949..2080845	-	897	WP_126446667.1	glucose-1-phosphate thymidylyltransferase RfbA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-137)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 149 a.a.
• Molecular weight: 16009.53 Da
• Isoelectric Point: 8.0963

>T31984 WP_126446655.1 NZ_AP018718:c2076706-2076260 [Sulfuricystis multivorans]
MTLVDANLLIDAVNRDLPQHKAAKAWWEKVLSGATTVGIPWVSVLAFLRICTSPRIFPKPLTPEDAVAYVDGWLAKPPVR
LVAPGGAPGGAHWAILRNLLVHTGTAANLSTDNHIAALALEQGYDIYSADNDFARFPGLKHINPLFPK

Nucleotide

• Length: 447 bp

>T31984 NZ_AP018718:c2076706-2076260 [Sulfuricystis multivorans]
ATGACCCTGGTCGATGCCAATCTGCTGATTGATGCGGTCAACCGGGACCTGCCCCAGCACAAGGCGGCGAAGGCGTGGTG
GGAGAAGGTCTTGTCGGGTGCGACGACGGTCGGCATTCCCTGGGTGTCGGTGCTGGCCTTCCTTCGCATTTGCACCAGTC
CGCGCATTTTCCCCAAGCCATTGACGCCCGAAGATGCCGTAGCCTACGTGGACGGCTGGCTTGCGAAGCCGCCCGTGCGC
CTGGTCGCCCCCGGTGGCGCCCCCGGTGGCGCCCACTGGGCGATCCTGCGCAATCTGCTGGTGCACACGGGCACCGCGGC
GAATCTCAGCACCGACAACCATATCGCCGCGTTGGCCCTCGAGCAGGGTTACGACATCTATTCCGCCGACAATGATTTCG
CGCGCTTCCCGGGGTTGAAACACATCAACCCCTTGTTCCCCAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9363.97 Da
• Isoelectric Point: 10.8056

>AT31984 WP_126446657.1 NZ_AP018718:c2076963-2076703 [Sulfuricystis multivorans]
MRTTITLEDGLASELKKQALASGKSFKQVVNEILLAGLQRQTRPRPYRLKPAALGAPAAGVDLAKALQLADELENLALRA
KLEQRK

Nucleotide

• Length: 261 bp

>AT31984 NZ_AP018718:c2076963-2076703 [Sulfuricystis multivorans]
ATGCGAACCACGATCACCCTCGAAGATGGCTTGGCAAGCGAATTGAAAAAACAGGCATTGGCATCGGGAAAGTCCTTCAA
GCAGGTGGTGAATGAAATCCTGCTTGCCGGCCTACAGCGCCAGACGCGCCCGCGTCCATATCGCCTGAAGCCGGCGGCGC
TCGGCGCACCTGCCGCCGGCGTCGATCTCGCCAAAGCCCTGCAACTGGCGGACGAGCTGGAGAATCTGGCTCTGCGCGCC
AAGCTCGAGCAGCGCAAATGA