Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-PrlF
Location 1729617..1730175 Replicon chromosome
Accession NZ_AP018718
Organism Sulfuricystis multivorans strain J5B

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL335_RS08610 Protein ID WP_126445976.1
Coordinates 1729617..1729955 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL335_RS08615 Protein ID WP_126445978.1
Coordinates 1729945..1730175 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL335_RS08595 1726747..1727682 - 936 WP_126445972.1 bifunctional riboflavin kinase/FAD synthetase -
EL335_RS08600 1727715..1728911 - 1197 WP_284155499.1 N-acetylmuramoyl-L-alanine amidase -
EL335_RS08605 1728923..1729624 - 702 WP_284155300.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
EL335_RS08610 1729617..1729955 - 339 WP_126445976.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL335_RS08615 1729945..1730175 - 231 WP_126445978.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
EL335_RS08620 1730265..1731302 + 1038 WP_126445980.1 tRNA epoxyqueuosine(34) reductase QueG -
EL335_RS08625 1731290..1732147 - 858 WP_126445982.1 sulfurtransferase -
EL335_RS08630 1732147..1732500 - 354 WP_126445984.1 STAS/SEC14 domain-containing protein -
EL335_RS08635 1732497..1733609 - 1113 WP_126445986.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
EL335_RS08640 1733756..1733998 + 243 WP_126445989.1 exodeoxyribonuclease VII small subunit -
EL335_RS08645 1733995..1734882 + 888 WP_126445991.1 polyprenyl synthetase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-109)

Antitoxin

PrlF antitoxin

(5-47)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12212.21 Da        Isoelectric Point: 8.8072

>T31983 WP_126445976.1 NZ_AP018718:c1729955-1729617 [Sulfuricystis multivorans]
VTFDRFAVVRVPFPFTDRCAVKNRPALVLSSAERFNAPTGHAVMAMITSAANAPWALDCPIEDLSAAGLPAPSKVRFKLF
TLDCRLVRGELGKLSNEDIERVRTRLEALLGG

Download         Length: 339 bp

>T31983 NZ_AP018718:c1729955-1729617 [Sulfuricystis multivorans]
GTGACCTTTGATCGCTTCGCGGTCGTGCGGGTGCCGTTTCCGTTTACCGACCGCTGCGCAGTGAAGAACCGGCCTGCCTT
GGTGCTTTCGTCGGCCGAACGGTTCAATGCTCCGACGGGTCATGCAGTGATGGCGATGATTACCTCTGCGGCCAATGCGC
CGTGGGCGCTCGATTGCCCGATCGAAGATCTTTCTGCCGCCGGCTTGCCGGCCCCATCCAAAGTGCGTTTCAAGCTTTTT
ACCCTCGATTGCCGACTGGTGCGCGGGGAGCTTGGCAAACTCTCGAACGAAGACATCGAGCGCGTGCGAACACGGTTGGA
GGCGCTGCTGGGTGGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8191.26 Da        Isoelectric Point: 4.3297

>AT31983 WP_126445978.1 NZ_AP018718:c1730175-1729945 [Sulfuricystis multivorans]
MLAIAKITAKGQTTIPHEVRAALQVAPGDLIAWEIGADGTATVRRVQPLDLDYLRAIEGTLSEWAGSADEEAYRDL

Download         Length: 231 bp

>AT31983 NZ_AP018718:c1730175-1729945 [Sulfuricystis multivorans]
ATGCTTGCCATCGCCAAGATCACCGCCAAGGGACAAACCACCATTCCACACGAGGTGCGCGCCGCGCTACAGGTCGCACC
AGGCGATTTGATCGCTTGGGAAATCGGCGCCGACGGAACGGCGACGGTACGCCGCGTGCAACCGCTCGATCTCGATTATC
TGCGTGCGATTGAGGGCACGCTTTCCGAATGGGCCGGCAGCGCCGATGAGGAAGCCTATCGTGACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References