Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 363386..363942 Replicon chromosome
Accession NZ_AP018718
Organism Sulfuricystis multivorans strain J5B

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag EL335_RS01725 Protein ID WP_126443955.1
Coordinates 363386..363703 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag EL335_RS01730 Protein ID WP_126443956.1
Coordinates 363703..363942 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL335_RS01700 359111..359347 + 237 WP_126443950.1 DUF2892 domain-containing protein -
EL335_RS01705 359365..359970 + 606 WP_126443951.1 DUF4202 domain-containing protein -
EL335_RS14270 359998..360147 + 150 WP_172599996.1 hypothetical protein -
EL335_RS01710 360144..360488 + 345 WP_126443952.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
EL335_RS01715 360488..361639 + 1152 WP_126443953.1 pyridoxal phosphate-dependent aminotransferase -
EL335_RS01720 361718..363382 - 1665 WP_126443954.1 energy-dependent translational throttle protein EttA -
EL335_RS01725 363386..363703 - 318 WP_126443955.1 CcdB family protein Toxin
EL335_RS01730 363703..363942 - 240 WP_126443956.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EL335_RS01735 364035..365234 - 1200 WP_284155406.1 HD domain-containing phosphohydrolase -
EL335_RS01740 365200..365403 - 204 WP_126443957.1 hypothetical protein -
EL335_RS01745 365416..366264 - 849 WP_126443958.1 orotidine-5'-phosphate decarboxylase -
EL335_RS01750 366261..367937 - 1677 WP_126443959.1 glutamine--tRNA ligase/YqeY domain fusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(5-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11674.48 Da        Isoelectric Point: 4.1127

>T31980 WP_126443955.1 NZ_AP018718:c363703-363386 [Sulfuricystis multivorans]
MAQFDVFPNTDDESARVVPYVLDIQSDFLDGLSTRVVIPLAIAEALDTLPILRLNPSLNIDGQPLIALTQDMAPVPRRLL
RHPVANLSFQREEILAAIDFLFTGF

Download         Length: 318 bp

>T31980 NZ_AP018718:c363703-363386 [Sulfuricystis multivorans]
ATGGCGCAGTTCGATGTTTTCCCCAACACGGATGACGAGAGCGCGCGCGTCGTGCCCTATGTTCTCGACATCCAGAGCGA
TTTTCTCGACGGGCTGTCGACGCGCGTCGTCATTCCCTTGGCCATTGCCGAGGCGCTGGACACCTTGCCCATCCTGCGCT
TGAACCCGTCCCTGAACATCGACGGCCAACCTCTGATCGCCCTCACGCAGGACATGGCGCCCGTCCCGCGTCGCCTGTTA
CGCCATCCCGTCGCCAACCTTTCTTTCCAGCGCGAGGAAATCCTCGCGGCCATCGATTTTCTCTTCACTGGATTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9414.74 Da        Isoelectric Point: 10.2614

>AT31980 WP_126443956.1 NZ_AP018718:c363942-363703 [Sulfuricystis multivorans]
MSAAKKAANLSIRADLLEEARAFKINLSQTLEAALQAEIKKEKERRWREENRAAIDAYNRYIEKYGLFSDRYRTFMRER

Download         Length: 240 bp

>AT31980 NZ_AP018718:c363942-363703 [Sulfuricystis multivorans]
ATGTCCGCTGCCAAAAAAGCCGCCAATCTCAGCATCCGCGCCGACTTGCTCGAAGAAGCGCGCGCCTTCAAGATCAACCT
CTCGCAGACGCTCGAGGCCGCCTTGCAGGCTGAAATCAAGAAAGAGAAAGAACGCCGCTGGCGGGAAGAGAACCGCGCCG
CGATCGATGCCTATAACCGCTACATCGAAAAATACGGCCTGTTCTCTGACCGCTATCGCACTTTCATGCGCGAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References