Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 2658329..2658860 Replicon chromosome
Accession NZ_AP018711
Organism Sphingosinicella microcystinivorans strain B-9

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag SmB9_RS12475 Protein ID WP_121048473.1
Coordinates 2658329..2658523 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag SmB9_RS12480 Protein ID WP_170151756.1
Coordinates 2658615..2658860 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SmB9_RS12450 2654476..2656341 + 1866 WP_121048462.1 ribonucleoside-diphosphate reductase subunit alpha -
SmB9_RS12455 2656351..2656587 + 237 WP_126494758.1 hypothetical protein -
SmB9_RS12460 2656643..2657683 + 1041 WP_121048465.1 ribonucleotide-diphosphate reductase subunit beta -
SmB9_RS12465 2657689..2657880 + 192 WP_121048468.1 KTSC domain-containing protein -
SmB9_RS12470 2657978..2658277 + 300 WP_121048470.1 hypothetical protein -
SmB9_RS12475 2658329..2658523 - 195 WP_121048473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SmB9_RS12480 2658615..2658860 - 246 WP_170151756.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SmB9_RS12485 2658908..2659246 - 339 WP_121048476.1 hypothetical protein -
SmB9_RS12490 2659546..2659815 - 270 WP_121048479.1 DUF167 domain-containing protein -
SmB9_RS12495 2659819..2660160 - 342 WP_121049923.1 DMT family protein -
SmB9_RS12500 2660327..2660722 + 396 WP_121048482.1 glycine zipper 2TM domain-containing protein -
SmB9_RS12505 2660793..2661332 + 540 WP_121048485.1 hypothetical protein -
SmB9_RS12510 2661370..2661705 + 336 WP_126494760.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-57)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7262.56 Da        Isoelectric Point: 10.8866

>T31979 WP_121048473.1 NZ_AP018711:c2658523-2658329 [Sphingosinicella microcystinivorans]
MAKLKQSFELLSRHPEAGTLCTNLRNPYRALPCRSHRIFYAVGDQGVRIVRVLHAAMSAERVLI

Download         Length: 195 bp

>T31979 NZ_AP018711:c2658523-2658329 [Sphingosinicella microcystinivorans]
ATGGCGAAACTAAAGCAGAGCTTTGAACTGCTCTCGCGGCACCCGGAGGCGGGAACGCTCTGCACCAATCTCAGGAACCC
CTATCGGGCCCTACCCTGCCGCAGCCATCGTATCTTTTATGCCGTCGGCGATCAGGGCGTTCGCATTGTGCGTGTGCTTC
ACGCCGCGATGAGCGCAGAACGCGTGCTGATTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9125.14 Da        Isoelectric Point: 7.2039

>AT31979 WP_170151756.1 NZ_AP018711:c2658860-2658615 [Sphingosinicella microcystinivorans]
MAQMNVSIPDALKSWAEHRVAEGRYSSTSDYVRDLIRRDQERADELAALEAALDAGEKSGISKRTIDDVIADHQKRRRAR
G

Download         Length: 246 bp

>AT31979 NZ_AP018711:c2658860-2658615 [Sphingosinicella microcystinivorans]
ATGGCACAGATGAACGTCTCGATCCCCGACGCCCTAAAAAGTTGGGCGGAACACCGCGTGGCCGAAGGCCGCTACAGCAG
CACCAGCGACTATGTGCGCGACCTGATCCGGCGGGATCAGGAACGGGCGGACGAACTGGCGGCGCTGGAAGCCGCGCTCG
ATGCAGGGGAGAAGTCGGGTATCAGCAAGCGCACCATCGACGATGTGATCGCAGACCACCAGAAACGCCGCCGCGCGCGT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References