Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2020115..2020715 Replicon chromosome
Accession NZ_AP018711
Organism Sphingosinicella microcystinivorans strain B-9

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag SmB9_RS09670 Protein ID WP_197723593.1
Coordinates 2020350..2020715 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag SmB9_RS09665 Protein ID WP_121047768.1
Coordinates 2020115..2020360 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SmB9_RS09630 2015277..2015888 - 612 WP_121047761.1 HAD family hydrolase -
SmB9_RS09635 2015885..2016163 - 279 WP_121047762.1 DUF3572 domain-containing protein -
SmB9_RS09640 2016268..2016630 + 363 WP_121047763.1 response regulator -
SmB9_RS09645 2016667..2016834 - 168 WP_121047764.1 50S ribosomal protein L33 -
SmB9_RS09650 2017134..2017382 + 249 WP_121047765.1 Hpt domain-containing protein -
SmB9_RS09655 2017386..2019596 - 2211 WP_121047766.1 ribonuclease R -
SmB9_RS09660 2019637..2019954 - 318 WP_121047767.1 quaternary ammonium compound efflux SMR transporter SugE -
SmB9_RS09665 2020115..2020360 + 246 WP_121047768.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SmB9_RS09670 2020350..2020715 + 366 WP_197723593.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SmB9_RS09675 2020723..2020902 - 180 WP_121047770.1 hypothetical protein -
SmB9_RS09680 2020908..2023490 - 2583 WP_121047771.1 type I DNA topoisomerase -
SmB9_RS09685 2023527..2023910 - 384 WP_121049752.1 arsenate reductase family protein -
SmB9_RS09690 2023927..2025420 - 1494 WP_121047772.1 amidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(30-115)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13591.54 Da        Isoelectric Point: 9.4110

>T31978 WP_197723593.1 NZ_AP018711:2020350-2020715 [Sphingosinicella microcystinivorans]
MAGRASRGKVGTGFPQKAMRQQTARGGGFRLTPRAEADLEDIFAYTVQRWSVMQAEDYHAGLMAGLERLGEGKRSGRPVE
ILGGYLKYVVGSHLVFYRETEADIVIVRILHQRMDVEQHLE

Download         Length: 366 bp

>T31978 NZ_AP018711:2020350-2020715 [Sphingosinicella microcystinivorans]
ATGGCGGGTAGAGCATCGCGCGGAAAAGTGGGAACCGGTTTTCCGCAAAAAGCGATGCGACAACAAACAGCTAGGGGCGG
AGGTTTCCGCCTGACGCCGCGCGCCGAAGCCGACCTCGAAGACATTTTCGCTTACACGGTCCAGCGCTGGTCGGTCATGC
AGGCCGAAGACTATCATGCGGGTTTGATGGCGGGGCTGGAAAGACTTGGCGAGGGTAAGCGCTCGGGACGCCCAGTCGAA
ATCCTGGGCGGATATCTCAAATACGTGGTCGGCTCACATCTCGTCTTTTATCGCGAAACCGAAGCCGACATTGTGATTGT
GCGCATCCTTCACCAGCGGATGGATGTGGAGCAGCACCTCGAATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8776.81 Da        Isoelectric Point: 8.8335

>AT31978 WP_121047768.1 NZ_AP018711:2020115-2020360 [Sphingosinicella microcystinivorans]
MARNTSISLGEHFSGFIDMQVGSGRYGSASDVIRAGLRLLEEREARVRALQAALAEGEASGDPRPFDNTAFLNRMRARHG
G

Download         Length: 246 bp

>AT31978 NZ_AP018711:2020115-2020360 [Sphingosinicella microcystinivorans]
ATGGCGCGAAATACATCAATCTCTCTCGGCGAACATTTCAGCGGCTTTATCGATATGCAGGTCGGCAGCGGCCGCTATGG
TTCTGCGAGCGATGTCATACGCGCGGGATTGCGACTTCTCGAAGAACGCGAGGCAAGGGTGCGCGCATTGCAGGCTGCGC
TTGCGGAAGGGGAAGCCTCAGGCGATCCGCGACCCTTCGACAATACGGCTTTCCTGAACCGGATGCGCGCCCGGCATGGC
GGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References