Detailed information of TA system TA031976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 23575..24115
• Replicon: plasmid 2
• Accession: NZ_AP018688
• Organism: Vibrio rumoiensis strain FERM P-14531

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VRUMOI_RS18820
• Protein ID: WP_027695183.1
• Coordinates: 23819..24115 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: VRUMOI_RS18815
• Protein ID: WP_027695182.1
• Coordinates: 23575..23832 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VRUMOI_RS18800	19790..19996	+	207	WP_089138980.1	peptidoglycan-binding protein	-
VRUMOI_RS18805	20037..20846	-	810	WP_162598466.1	RsiV family protein	-
VRUMOI_RS18810	22121..23182	+	1062	WP_089138977.1	tyrosine-type recombinase/integrase	-
VRUMOI_RS18815	23575..23832	+	258	WP_027695182.1	antitoxin	Antitoxin
VRUMOI_RS18820	23819..24115	+	297	WP_027695183.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VRUMOI_RS18825	24586..25755	-	1170	WP_162598467.1	group II intron reverse transcriptase/maturase	-
VRUMOI_RS18830	26117..26725	+	609	WP_040223437.1	recombinase family protein	-
VRUMOI_RS18835	26722..26907	-	186	WP_024562121.1	ribbon-helix-helix domain-containing protein	-
VRUMOI_RS18840	27384..28388	-	1005	WP_000427614.1	IS110-like element IS5075 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..109617	109617
	-	flank	IS/Tn	-	-	27384..28388	1004

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11376.69 Da
• Isoelectric Point: 10.6637

>T31976 WP_027695183.1 NZ_AP018688:23819-24115 [Vibrio rumoiensis]
MTVYKLKFERKAQKLFSKLGEPVKSQFKEKLKKIQVNPHIEANKLHGGLSGCYKIKLKQSGYRLVYKVVDDELIVLILAV
GKREKKEAYLMAQRLLNK

Nucleotide

• Length: 297 bp

>T31976 NZ_AP018688:23819-24115 [Vibrio rumoiensis]
TTGACAGTTTATAAGTTGAAATTTGAACGAAAAGCCCAAAAACTTTTCTCTAAATTAGGAGAGCCGGTTAAATCTCAGTT
CAAAGAAAAACTCAAAAAGATTCAAGTTAATCCGCACATAGAGGCAAACAAATTACATGGTGGATTATCGGGATGTTACA
AAATCAAACTCAAGCAATCTGGTTATCGACTGGTTTATAAAGTTGTTGATGATGAATTAATCGTGCTTATCTTAGCCGTC
GGAAAACGAGAAAAAAAAGAAGCCTATTTAATGGCTCAAAGACTGTTAAATAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9354.66 Da
• Isoelectric Point: 3.9554

>AT31976 WP_027695182.1 NZ_AP018688:23575-23832 [Vibrio rumoiensis]
MNLTNNILTDVSAGLTQLKNNPMGVLEEGHGAPVAILNRNKPAFYAVPAALYEKMVDELENIELMKMAQEAYETGEFVEV
DLDSL

Nucleotide

• Length: 258 bp

>AT31976 NZ_AP018688:23575-23832 [Vibrio rumoiensis]
ATGAACTTAACAAACAACATTTTGACGGATGTGAGTGCTGGACTTACTCAGCTCAAAAATAATCCAATGGGCGTATTAGA
AGAAGGCCATGGTGCGCCTGTTGCTATTTTAAATCGCAACAAACCTGCATTTTACGCTGTCCCAGCCGCTTTATATGAAA
AAATGGTTGATGAGCTTGAAAATATTGAGCTAATGAAAATGGCTCAAGAAGCTTATGAAACGGGTGAGTTTGTTGAGGTA
GACCTTGACAGTTTATAA