Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-YefM |
Location | 53349..53920 | Replicon | plasmid 1 |
Accession | NZ_AP018687 | ||
Organism | Vibrio rumoiensis strain FERM P-14531 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A2I8S8S5 |
Locus tag | VRUMOI_RS18110 | Protein ID | WP_011918375.1 |
Coordinates | 53349..53660 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A1Z3MW28 |
Locus tag | VRUMOI_RS18115 | Protein ID | WP_011787805.1 |
Coordinates | 53660..53920 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
VRUMOI_RS18090 | 48651..49046 | + | 396 | WP_006217728.1 | transposase | - |
VRUMOI_RS18095 | 49043..49375 | + | 333 | WP_003121550.1 | IS66 family insertion sequence element accessory protein TnpB | - |
VRUMOI_RS18100 | 49452..50192 | + | 741 | Protein_67 | transposase | - |
VRUMOI_RS18105 | 50245..53325 | - | 3081 | WP_011787830.1 | Tn3 family transposase | - |
VRUMOI_RS18110 | 53349..53660 | - | 312 | WP_011918375.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
VRUMOI_RS18115 | 53660..53920 | - | 261 | WP_011787805.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
VRUMOI_RS18120 | 54090..54710 | + | 621 | WP_011787804.1 | recombinase family protein | - |
VRUMOI_RS18130 | 54887..56176 | - | 1290 | WP_004574636.1 | ISL3-like element ISPpu12 family transposase | - |
VRUMOI_RS18135 | 56198..56710 | - | 513 | WP_089140475.1 | signal peptidase II | - |
VRUMOI_RS18140 | 56714..57610 | - | 897 | WP_089140476.1 | cation diffusion facilitator family transporter | - |
VRUMOI_RS18145 | 57706..58113 | + | 408 | WP_004364961.1 | Cd(II)/Pb(II)-responsive transcriptional regulator | - |
VRUMOI_RS18150 | 58208..58540 | - | 333 | WP_011787803.1 | TraR/DksA C4-type zinc finger protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | katA | 1..159324 | 159324 | |
- | flank | IS/Tn | - | - | 49043..49375 | 332 | |
- | flank | IS/Tn | - | - | 54887..56176 | 1289 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11862.70 Da Isoelectric Point: 8.5341
>T31975 WP_011918375.1 NZ_AP018687:c53660-53349 [Vibrio rumoiensis]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII
Download Length: 312 bp
>T31975 NZ_AP018687:c53660-53349 [Vibrio rumoiensis]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9312.71 Da Isoelectric Point: 6.4546
>AT31975 WP_011787805.1 NZ_AP018687:c53920-53660 [Vibrio rumoiensis]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD
Download Length: 261 bp
>AT31975 NZ_AP018687:c53920-53660 [Vibrio rumoiensis]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2I8S8S5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Z3MW28 |