Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 53349..53920 Replicon plasmid 1
Accession NZ_AP018687
Organism Vibrio rumoiensis strain FERM P-14531

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag VRUMOI_RS18110 Protein ID WP_011918375.1
Coordinates 53349..53660 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag VRUMOI_RS18115 Protein ID WP_011787805.1
Coordinates 53660..53920 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VRUMOI_RS18090 48651..49046 + 396 WP_006217728.1 transposase -
VRUMOI_RS18095 49043..49375 + 333 WP_003121550.1 IS66 family insertion sequence element accessory protein TnpB -
VRUMOI_RS18100 49452..50192 + 741 Protein_67 transposase -
VRUMOI_RS18105 50245..53325 - 3081 WP_011787830.1 Tn3 family transposase -
VRUMOI_RS18110 53349..53660 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VRUMOI_RS18115 53660..53920 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VRUMOI_RS18120 54090..54710 + 621 WP_011787804.1 recombinase family protein -
VRUMOI_RS18130 54887..56176 - 1290 WP_004574636.1 ISL3-like element ISPpu12 family transposase -
VRUMOI_RS18135 56198..56710 - 513 WP_089140475.1 signal peptidase II -
VRUMOI_RS18140 56714..57610 - 897 WP_089140476.1 cation diffusion facilitator family transporter -
VRUMOI_RS18145 57706..58113 + 408 WP_004364961.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
VRUMOI_RS18150 58208..58540 - 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..159324 159324
- flank IS/Tn - - 49043..49375 332
- flank IS/Tn - - 54887..56176 1289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T31975 WP_011918375.1 NZ_AP018687:c53660-53349 [Vibrio rumoiensis]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T31975 NZ_AP018687:c53660-53349 [Vibrio rumoiensis]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT31975 WP_011787805.1 NZ_AP018687:c53920-53660 [Vibrio rumoiensis]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT31975 NZ_AP018687:c53920-53660 [Vibrio rumoiensis]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References