Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
Location | 2472029..2473863 | Replicon | chromosome |
Accession | NZ_AP018685 | ||
Organism | Vibrio rumoiensis strain FERM P-14531 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | VRUMOI_RS11275 | Protein ID | WP_089139631.1 |
Coordinates | 2472029..2473378 (+) | Length | 450 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | VRUMOI_RS11280 | Protein ID | WP_089139630.1 |
Coordinates | 2473375..2473863 (+) | Length | 163 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
VRUMOI_RS11250 | 2467268..2468353 | - | 1086 | WP_110410657.1 | hypothetical protein | - |
VRUMOI_RS11255 | 2468346..2468981 | - | 636 | WP_089139634.1 | hypothetical protein | - |
VRUMOI_RS11260 | 2469386..2470543 | + | 1158 | WP_110410658.1 | site-specific integrase | - |
VRUMOI_RS11265 | 2470544..2471164 | + | 621 | WP_089139632.1 | hypothetical protein | - |
VRUMOI_RS11270 | 2471335..2471652 | - | 318 | WP_089139639.1 | HipA N-terminal domain-containing protein | - |
VRUMOI_RS11275 | 2472029..2473378 | + | 1350 | WP_089139631.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
VRUMOI_RS11280 | 2473375..2473863 | + | 489 | WP_089139630.1 | helix-turn-helix domain-containing protein | Antitoxin |
VRUMOI_RS11285 | 2474409..2475650 | - | 1242 | WP_089139629.1 | HipA domain-containing protein | - |
VRUMOI_RS11290 | 2475664..2475981 | - | 318 | WP_089139628.1 | helix-turn-helix domain-containing protein | - |
VRUMOI_RS19240 | 2476497..2476652 | - | 156 | WP_162598369.1 | hypothetical protein | - |
VRUMOI_RS11295 | 2477176..2477409 | - | 234 | WP_089139627.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 51034.06 Da Isoelectric Point: 4.6564
>T31971 WP_089139631.1 NZ_AP018685:2472029-2473378 [Vibrio rumoiensis]
MESLTIQAYILGIWSDIAQITFPKSDQGNFVTTEIHYQKEYALAHFEKDDMHAVSINYPVNFFFDDMGRSGWLRFLDDIM
PSGASRGFWVKQLDIEDLSIEQQNFILLKYGTISPVGNLRIKESLPMRTEKSDSLLFAISDVIDRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSNDGKIWIDSFQDDITNQDLHYLVKYPRGARGQIDCNILRAEFYYYHELTNLGIDTIPIESMR
LEEGTNYPSLWLPRFDIYIDKERNIQRYSMESVYSILNKGPGSLLDHEETIRELICKIMNSHMVTEQGFQFDVQGFVIEW
VKRDLLNILFGNSDNHGRNTSFIKGDGYIKLAPIYDFAPMKADPDGIPRTTKWKSPLEVGGEYDFDGIASSLSDLVSKET
LLSELKEVAKNCLTLKERLEESGVPKQILDMPAIGMDFITIKLKKWGLV
MESLTIQAYILGIWSDIAQITFPKSDQGNFVTTEIHYQKEYALAHFEKDDMHAVSINYPVNFFFDDMGRSGWLRFLDDIM
PSGASRGFWVKQLDIEDLSIEQQNFILLKYGTISPVGNLRIKESLPMRTEKSDSLLFAISDVIDRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSNDGKIWIDSFQDDITNQDLHYLVKYPRGARGQIDCNILRAEFYYYHELTNLGIDTIPIESMR
LEEGTNYPSLWLPRFDIYIDKERNIQRYSMESVYSILNKGPGSLLDHEETIRELICKIMNSHMVTEQGFQFDVQGFVIEW
VKRDLLNILFGNSDNHGRNTSFIKGDGYIKLAPIYDFAPMKADPDGIPRTTKWKSPLEVGGEYDFDGIASSLSDLVSKET
LLSELKEVAKNCLTLKERLEESGVPKQILDMPAIGMDFITIKLKKWGLV
Download Length: 1350 bp
>T31971 NZ_AP018685:2472029-2473378 [Vibrio rumoiensis]
ATGGAATCACTAACGATACAAGCCTACATACTCGGAATATGGTCTGATATTGCACAAATTACTTTCCCTAAAAGTGATCA
AGGTAATTTCGTCACGACAGAGATTCACTATCAAAAAGAGTATGCACTCGCTCACTTCGAGAAAGATGACATGCATGCCG
TTTCAATTAATTACCCAGTTAATTTCTTCTTTGATGATATGGGCCGTTCGGGTTGGTTGAGATTTCTTGACGACATTATG
CCAAGCGGTGCAAGTCGAGGTTTTTGGGTCAAACAGCTTGATATTGAAGATCTCTCTATTGAACAGCAAAATTTCATTCT
GTTGAAATATGGCACTATCTCCCCTGTCGGTAACCTGAGAATAAAAGAATCTTTACCTATGCGAACTGAAAAATCAGATT
CGCTCTTGTTTGCAATTAGTGATGTTATCGACCGAGCCAGTGATTTCTTAGATTATGCCCAAGAAAGAGGAGCAGCGGCT
GGCGGTGCAACCGGTGCTGGTGGTGAAGCACCCAAATTATTACTACGTTGTTCTAACGACGGTAAAATCTGGATTGATAG
TTTTCAAGACGATATAACAAATCAAGATTTACACTATTTAGTAAAATATCCTAGAGGTGCTCGGGGGCAAATAGACTGCA
ATATTTTACGCGCTGAATTTTATTATTACCATGAACTAACAAACCTAGGCATCGATACCATTCCTATTGAATCTATGCGC
TTAGAAGAAGGTACAAATTACCCCTCTCTTTGGCTACCAAGATTCGATATCTATATTGATAAAGAGCGGAATATTCAGCG
CTATTCTATGGAATCTGTTTACTCCATTTTGAATAAAGGGCCTGGCAGCCTTCTCGACCATGAAGAAACTATTCGGGAGC
TGATTTGTAAAATCATGAATAGTCATATGGTTACCGAGCAGGGATTTCAATTTGATGTTCAAGGTTTTGTCATTGAATGG
GTAAAGCGAGACTTGCTCAATATTCTATTTGGTAATAGTGACAATCATGGAAGAAACACCTCCTTCATTAAAGGCGACGG
TTATATCAAACTCGCTCCAATTTATGACTTTGCACCAATGAAAGCCGACCCTGATGGCATACCAAGAACAACCAAATGGA
AATCACCATTAGAAGTCGGTGGTGAATATGATTTTGATGGTATAGCAAGTTCATTATCAGATTTAGTCTCTAAAGAAACC
TTATTAAGTGAACTTAAAGAAGTAGCTAAAAACTGCCTTACTTTAAAAGAAAGGTTAGAAGAAAGTGGCGTACCAAAGCA
AATTTTAGATATGCCAGCCATTGGCATGGATTTCATTACTATAAAATTGAAAAAATGGGGGCTGGTATGA
ATGGAATCACTAACGATACAAGCCTACATACTCGGAATATGGTCTGATATTGCACAAATTACTTTCCCTAAAAGTGATCA
AGGTAATTTCGTCACGACAGAGATTCACTATCAAAAAGAGTATGCACTCGCTCACTTCGAGAAAGATGACATGCATGCCG
TTTCAATTAATTACCCAGTTAATTTCTTCTTTGATGATATGGGCCGTTCGGGTTGGTTGAGATTTCTTGACGACATTATG
CCAAGCGGTGCAAGTCGAGGTTTTTGGGTCAAACAGCTTGATATTGAAGATCTCTCTATTGAACAGCAAAATTTCATTCT
GTTGAAATATGGCACTATCTCCCCTGTCGGTAACCTGAGAATAAAAGAATCTTTACCTATGCGAACTGAAAAATCAGATT
CGCTCTTGTTTGCAATTAGTGATGTTATCGACCGAGCCAGTGATTTCTTAGATTATGCCCAAGAAAGAGGAGCAGCGGCT
GGCGGTGCAACCGGTGCTGGTGGTGAAGCACCCAAATTATTACTACGTTGTTCTAACGACGGTAAAATCTGGATTGATAG
TTTTCAAGACGATATAACAAATCAAGATTTACACTATTTAGTAAAATATCCTAGAGGTGCTCGGGGGCAAATAGACTGCA
ATATTTTACGCGCTGAATTTTATTATTACCATGAACTAACAAACCTAGGCATCGATACCATTCCTATTGAATCTATGCGC
TTAGAAGAAGGTACAAATTACCCCTCTCTTTGGCTACCAAGATTCGATATCTATATTGATAAAGAGCGGAATATTCAGCG
CTATTCTATGGAATCTGTTTACTCCATTTTGAATAAAGGGCCTGGCAGCCTTCTCGACCATGAAGAAACTATTCGGGAGC
TGATTTGTAAAATCATGAATAGTCATATGGTTACCGAGCAGGGATTTCAATTTGATGTTCAAGGTTTTGTCATTGAATGG
GTAAAGCGAGACTTGCTCAATATTCTATTTGGTAATAGTGACAATCATGGAAGAAACACCTCCTTCATTAAAGGCGACGG
TTATATCAAACTCGCTCCAATTTATGACTTTGCACCAATGAAAGCCGACCCTGATGGCATACCAAGAACAACCAAATGGA
AATCACCATTAGAAGTCGGTGGTGAATATGATTTTGATGGTATAGCAAGTTCATTATCAGATTTAGTCTCTAAAGAAACC
TTATTAAGTGAACTTAAAGAAGTAGCTAAAAACTGCCTTACTTTAAAAGAAAGGTTAGAAGAAAGTGGCGTACCAAAGCA
AATTTTAGATATGCCAGCCATTGGCATGGATTTCATTACTATAAAATTGAAAAAATGGGGGCTGGTATGA
Antitoxin
Download Length: 163 a.a. Molecular weight: 18020.58 Da Isoelectric Point: 10.3143
>AT31971 WP_089139630.1 NZ_AP018685:2473375-2473863 [Vibrio rumoiensis]
MSTNKKNIDGSSDSSVESAHEAIARLRSRNQRLKTIEQLQSPINSSIEYVETEKKRASKHAPSIPASERQYKISEVIRTL
LMGELTQGQALKELRINVLGVKQDTFAKMVGVSRKTISEIENDRGVFKTDILDKAFKPFGLKVGLIPVSNSLLNSVLSNH
NE
MSTNKKNIDGSSDSSVESAHEAIARLRSRNQRLKTIEQLQSPINSSIEYVETEKKRASKHAPSIPASERQYKISEVIRTL
LMGELTQGQALKELRINVLGVKQDTFAKMVGVSRKTISEIENDRGVFKTDILDKAFKPFGLKVGLIPVSNSLLNSVLSNH
NE
Download Length: 489 bp
>AT31971 NZ_AP018685:2473375-2473863 [Vibrio rumoiensis]
ATGAGTACTAACAAAAAAAATATCGATGGTTCAAGTGATTCGTCAGTAGAATCAGCACATGAGGCTATAGCTCGACTTCG
CTCAAGAAATCAACGTTTAAAAACGATAGAGCAGCTACAATCCCCCATTAATAGCTCAATTGAGTACGTTGAAACAGAGA
AAAAGAGAGCGTCTAAACACGCACCATCAATACCTGCATCAGAAAGGCAGTACAAAATAAGTGAAGTTATTCGAACCTTA
TTAATGGGTGAGCTAACACAAGGACAAGCCCTTAAAGAGCTTCGGATCAATGTATTAGGTGTCAAACAAGATACATTCGC
CAAAATGGTTGGTGTTTCAAGAAAAACCATATCTGAGATAGAGAACGACCGTGGAGTTTTTAAAACAGATATTCTTGATA
AAGCGTTTAAGCCCTTCGGACTAAAAGTAGGGTTAATACCAGTTTCGAATAGCTTATTGAATTCCGTATTAAGTAATCAT
AATGAATGA
ATGAGTACTAACAAAAAAAATATCGATGGTTCAAGTGATTCGTCAGTAGAATCAGCACATGAGGCTATAGCTCGACTTCG
CTCAAGAAATCAACGTTTAAAAACGATAGAGCAGCTACAATCCCCCATTAATAGCTCAATTGAGTACGTTGAAACAGAGA
AAAAGAGAGCGTCTAAACACGCACCATCAATACCTGCATCAGAAAGGCAGTACAAAATAAGTGAAGTTATTCGAACCTTA
TTAATGGGTGAGCTAACACAAGGACAAGCCCTTAAAGAGCTTCGGATCAATGTATTAGGTGTCAAACAAGATACATTCGC
CAAAATGGTTGGTGTTTCAAGAAAAACCATATCTGAGATAGAGAACGACCGTGGAGTTTTTAAAACAGATATTCTTGATA
AAGCGTTTAAGCCCTTCGGACTAAAAGTAGGGTTAATACCAGTTTCGAATAGCTTATTGAATTCCGTATTAAGTAATCAT
AATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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