Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2472029..2473863 Replicon chromosome
Accession NZ_AP018685
Organism Vibrio rumoiensis strain FERM P-14531

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag VRUMOI_RS11275 Protein ID WP_089139631.1
Coordinates 2472029..2473378 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag VRUMOI_RS11280 Protein ID WP_089139630.1
Coordinates 2473375..2473863 (+) Length 163 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VRUMOI_RS11250 2467268..2468353 - 1086 WP_110410657.1 hypothetical protein -
VRUMOI_RS11255 2468346..2468981 - 636 WP_089139634.1 hypothetical protein -
VRUMOI_RS11260 2469386..2470543 + 1158 WP_110410658.1 site-specific integrase -
VRUMOI_RS11265 2470544..2471164 + 621 WP_089139632.1 hypothetical protein -
VRUMOI_RS11270 2471335..2471652 - 318 WP_089139639.1 HipA N-terminal domain-containing protein -
VRUMOI_RS11275 2472029..2473378 + 1350 WP_089139631.1 type II toxin-antitoxin system HipA family toxin Toxin
VRUMOI_RS11280 2473375..2473863 + 489 WP_089139630.1 helix-turn-helix domain-containing protein Antitoxin
VRUMOI_RS11285 2474409..2475650 - 1242 WP_089139629.1 HipA domain-containing protein -
VRUMOI_RS11290 2475664..2475981 - 318 WP_089139628.1 helix-turn-helix domain-containing protein -
VRUMOI_RS19240 2476497..2476652 - 156 WP_162598369.1 hypothetical protein -
VRUMOI_RS11295 2477176..2477409 - 234 WP_089139627.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-411)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-142)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51034.06 Da        Isoelectric Point: 4.6564

>T31971 WP_089139631.1 NZ_AP018685:2472029-2473378 [Vibrio rumoiensis]
MESLTIQAYILGIWSDIAQITFPKSDQGNFVTTEIHYQKEYALAHFEKDDMHAVSINYPVNFFFDDMGRSGWLRFLDDIM
PSGASRGFWVKQLDIEDLSIEQQNFILLKYGTISPVGNLRIKESLPMRTEKSDSLLFAISDVIDRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSNDGKIWIDSFQDDITNQDLHYLVKYPRGARGQIDCNILRAEFYYYHELTNLGIDTIPIESMR
LEEGTNYPSLWLPRFDIYIDKERNIQRYSMESVYSILNKGPGSLLDHEETIRELICKIMNSHMVTEQGFQFDVQGFVIEW
VKRDLLNILFGNSDNHGRNTSFIKGDGYIKLAPIYDFAPMKADPDGIPRTTKWKSPLEVGGEYDFDGIASSLSDLVSKET
LLSELKEVAKNCLTLKERLEESGVPKQILDMPAIGMDFITIKLKKWGLV

Download         Length: 1350 bp

>T31971 NZ_AP018685:2472029-2473378 [Vibrio rumoiensis]
ATGGAATCACTAACGATACAAGCCTACATACTCGGAATATGGTCTGATATTGCACAAATTACTTTCCCTAAAAGTGATCA
AGGTAATTTCGTCACGACAGAGATTCACTATCAAAAAGAGTATGCACTCGCTCACTTCGAGAAAGATGACATGCATGCCG
TTTCAATTAATTACCCAGTTAATTTCTTCTTTGATGATATGGGCCGTTCGGGTTGGTTGAGATTTCTTGACGACATTATG
CCAAGCGGTGCAAGTCGAGGTTTTTGGGTCAAACAGCTTGATATTGAAGATCTCTCTATTGAACAGCAAAATTTCATTCT
GTTGAAATATGGCACTATCTCCCCTGTCGGTAACCTGAGAATAAAAGAATCTTTACCTATGCGAACTGAAAAATCAGATT
CGCTCTTGTTTGCAATTAGTGATGTTATCGACCGAGCCAGTGATTTCTTAGATTATGCCCAAGAAAGAGGAGCAGCGGCT
GGCGGTGCAACCGGTGCTGGTGGTGAAGCACCCAAATTATTACTACGTTGTTCTAACGACGGTAAAATCTGGATTGATAG
TTTTCAAGACGATATAACAAATCAAGATTTACACTATTTAGTAAAATATCCTAGAGGTGCTCGGGGGCAAATAGACTGCA
ATATTTTACGCGCTGAATTTTATTATTACCATGAACTAACAAACCTAGGCATCGATACCATTCCTATTGAATCTATGCGC
TTAGAAGAAGGTACAAATTACCCCTCTCTTTGGCTACCAAGATTCGATATCTATATTGATAAAGAGCGGAATATTCAGCG
CTATTCTATGGAATCTGTTTACTCCATTTTGAATAAAGGGCCTGGCAGCCTTCTCGACCATGAAGAAACTATTCGGGAGC
TGATTTGTAAAATCATGAATAGTCATATGGTTACCGAGCAGGGATTTCAATTTGATGTTCAAGGTTTTGTCATTGAATGG
GTAAAGCGAGACTTGCTCAATATTCTATTTGGTAATAGTGACAATCATGGAAGAAACACCTCCTTCATTAAAGGCGACGG
TTATATCAAACTCGCTCCAATTTATGACTTTGCACCAATGAAAGCCGACCCTGATGGCATACCAAGAACAACCAAATGGA
AATCACCATTAGAAGTCGGTGGTGAATATGATTTTGATGGTATAGCAAGTTCATTATCAGATTTAGTCTCTAAAGAAACC
TTATTAAGTGAACTTAAAGAAGTAGCTAAAAACTGCCTTACTTTAAAAGAAAGGTTAGAAGAAAGTGGCGTACCAAAGCA
AATTTTAGATATGCCAGCCATTGGCATGGATTTCATTACTATAAAATTGAAAAAATGGGGGCTGGTATGA

Antitoxin


Download         Length: 163 a.a.        Molecular weight: 18020.58 Da        Isoelectric Point: 10.3143

>AT31971 WP_089139630.1 NZ_AP018685:2473375-2473863 [Vibrio rumoiensis]
MSTNKKNIDGSSDSSVESAHEAIARLRSRNQRLKTIEQLQSPINSSIEYVETEKKRASKHAPSIPASERQYKISEVIRTL
LMGELTQGQALKELRINVLGVKQDTFAKMVGVSRKTISEIENDRGVFKTDILDKAFKPFGLKVGLIPVSNSLLNSVLSNH
NE

Download         Length: 489 bp

>AT31971 NZ_AP018685:2473375-2473863 [Vibrio rumoiensis]
ATGAGTACTAACAAAAAAAATATCGATGGTTCAAGTGATTCGTCAGTAGAATCAGCACATGAGGCTATAGCTCGACTTCG
CTCAAGAAATCAACGTTTAAAAACGATAGAGCAGCTACAATCCCCCATTAATAGCTCAATTGAGTACGTTGAAACAGAGA
AAAAGAGAGCGTCTAAACACGCACCATCAATACCTGCATCAGAAAGGCAGTACAAAATAAGTGAAGTTATTCGAACCTTA
TTAATGGGTGAGCTAACACAAGGACAAGCCCTTAAAGAGCTTCGGATCAATGTATTAGGTGTCAAACAAGATACATTCGC
CAAAATGGTTGGTGTTTCAAGAAAAACCATATCTGAGATAGAGAACGACCGTGGAGTTTTTAAAACAGATATTCTTGATA
AAGCGTTTAAGCCCTTCGGACTAAAAGTAGGGTTAATACCAGTTTCGAATAGCTTATTGAATTCCGTATTAAGTAATCAT
AATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References