Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 106285..106825 Replicon plasmid 1
Accession NZ_AP018682
Organism Vibrio casei strain DSM 22364

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag VCASEI_RS18980 Protein ID WP_027695183.1
Coordinates 106285..106581 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag VCASEI_RS18985 Protein ID WP_027695182.1
Coordinates 106568..106825 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCASEI_RS19525 102501..102677 - 177 WP_162621116.1 hypothetical protein -
VCASEI_RS18955 102792..103942 + 1151 WP_110957751.1 IS3 family transposase -
VCASEI_RS18960 104249..105310 + 1062 WP_110957870.1 tyrosine-type recombinase/integrase -
VCASEI_RS18965 105404..105643 - 240 WP_110957871.1 hypothetical protein -
VCASEI_RS18970 105795..106004 - 210 WP_110957872.1 BrnA antitoxin family protein -
VCASEI_RS18975 105997..106263 - 267 WP_110957873.1 BrnT family toxin -
VCASEI_RS18980 106285..106581 - 297 WP_027695183.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCASEI_RS18985 106568..106825 - 258 WP_027695182.1 antitoxin Antitoxin
VCASEI_RS18990 107000..107904 + 905 Protein_106 IS3 family transposase -
VCASEI_RS18995 107935..109088 - 1154 Protein_107 IS3 family transposase -
VCASEI_RS19000 109334..109882 - 549 WP_110957874.1 hypothetical protein -
VCASEI_RS19005 110085..111224 - 1140 WP_110957875.1 FMN-dependent L-lactate dehydrogenase LldD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..160294 160294
- inside IScluster/Tn - - 102792..109088 6296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11376.69 Da        Isoelectric Point: 10.6637

>T31968 WP_027695183.1 NZ_AP018682:c106581-106285 [Vibrio casei]
MTVYKLKFERKAQKLFSKLGEPVKSQFKEKLKKIQVNPHIEANKLHGGLSGCYKIKLKQSGYRLVYKVVDDELIVLILAV
GKREKKEAYLMAQRLLNK

Download         Length: 297 bp

>T31968 NZ_AP018682:c106581-106285 [Vibrio casei]
TTGACAGTTTATAAGTTGAAATTTGAACGAAAAGCCCAAAAACTTTTCTCTAAATTAGGAGAGCCGGTTAAATCTCAGTT
CAAAGAAAAACTCAAAAAGATTCAAGTTAATCCGCACATAGAGGCAAACAAATTACATGGTGGATTATCGGGATGTTACA
AAATCAAACTCAAGCAATCTGGTTATCGACTGGTTTATAAAGTTGTTGATGATGAATTAATCGTGCTTATCTTAGCCGTC
GGAAAACGAGAAAAAAAAGAAGCCTATTTAATGGCTCAAAGACTGTTAAATAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9354.66 Da        Isoelectric Point: 3.9554

>AT31968 WP_027695182.1 NZ_AP018682:c106825-106568 [Vibrio casei]
MNLTNNILTDVSAGLTQLKNNPMGVLEEGHGAPVAILNRNKPAFYAVPAALYEKMVDELENIELMKMAQEAYETGEFVEV
DLDSL

Download         Length: 258 bp

>AT31968 NZ_AP018682:c106825-106568 [Vibrio casei]
ATGAACTTAACAAACAACATTTTGACGGATGTGAGTGCTGGACTTACTCAGCTCAAAAATAATCCAATGGGCGTATTAGA
AGAAGGCCATGGTGCGCCTGTTGCTATTTTAAATCGCAACAAACCTGCATTTTACGCTGTCCCAGCCGCTTTATATGAAA
AAATGGTTGATGAGCTTGAAAATATTGAGCTAATGAAAATGGCTCAAGAAGCTTATGAAACGGGTGAGTTTGTTGAGGTA
GACCTTGACAGTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References