Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 430604..432285 Replicon chromosome
Accession NZ_AP018680
Organism Vibrio casei strain DSM 22364

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag VCASEI_RS02125 Protein ID WP_089110284.1
Coordinates 430604..431827 (-) Length 408 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag VCASEI_RS02130 Protein ID WP_089110283.1
Coordinates 431818..432285 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCASEI_RS02075 425682..425924 - 243 WP_089110294.1 ogr/Delta-like zinc finger family protein -
VCASEI_RS02080 425962..426213 - 252 WP_089110293.1 hypothetical protein -
VCASEI_RS02085 426221..428107 - 1887 WP_089110292.1 replication endonuclease -
VCASEI_RS02090 428043..428333 - 291 WP_089110291.1 hypothetical protein -
VCASEI_RS02100 428557..428778 - 222 WP_089110289.1 hypothetical protein -
VCASEI_RS02105 428775..429011 - 237 WP_089110288.1 hypothetical protein -
VCASEI_RS02110 429011..429220 - 210 WP_089110287.1 hypothetical protein -
VCASEI_RS02115 429314..429568 - 255 WP_089110286.1 pyocin activator PrtN family protein -
VCASEI_RS02120 429715..430404 + 690 WP_089110285.1 transcriptional regulator -
VCASEI_RS02125 430604..431827 - 1224 WP_089110284.1 RelA/SpoT domain-containing protein Toxin
VCASEI_RS02130 431818..432285 - 468 WP_089110283.1 DUF4065 domain-containing protein Antitoxin
VCASEI_RS02135 432400..433476 - 1077 WP_089110282.1 site-specific integrase -
VCASEI_RS02140 433599..434609 + 1011 WP_089110281.1 tRNA dihydrouridine(20/20a) synthase DusA -
VCASEI_RS02145 434817..435029 + 213 WP_086962902.1 envelope stress response protein PspG -
VCASEI_RS02150 435070..435387 + 318 WP_086962900.1 hypothetical protein -
VCASEI_RS02155 435525..435755 + 231 WP_086962899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 382338..433476 51138


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(114-229)

Antitoxin

Antitoxin SocA-like, Panacea domain

(32-123)


Sequences

Toxin        


Download         Length: 408 a.a.        Molecular weight: 47062.78 Da        Isoelectric Point: 6.0001

>T31967 WP_089110284.1 NZ_AP018680:c431827-430604 [Vibrio casei]
MPIDDKKNHLEENLSVINFEVDGTFSLDEESIVEVDQSLEAFIQEQDLIPEIFVFTGGDVKRASDAYRKNIGNLKQSLEI
IQAFREAHEKPLKVISSLLSQCCEQLELNTKPVSRLKRTETIINKLQRPSLDGKTINQTCVKNMIDIAGCRLILPDMNSL
NNIAQHIENRVNSINRIEINKIKNYITDPKDNDCRYRSLHIHFKYKTKQGKPFKVEAQLRTEYQHAWATTVEIIDLLEHT
KIKTHSHSDLYKENQQKKWETLLIFMSDYIADKEGIITLSEEERSSISLRLSQLNDELHAASHLESFQMMTKKLESIITD
NKKQYILFLIEETEKKVLLEEIYNKEKEAIARYNLIEKAFTGIDSLNALLVSSEKMSSINKAYPNYAGDCSEFIKLLNEA
IKYKDLS

Download         Length: 1224 bp

>T31967 NZ_AP018680:c431827-430604 [Vibrio casei]
ATGCCTATAGATGATAAAAAAAATCATCTCGAGGAAAACTTAAGTGTCATCAATTTTGAAGTTGATGGCACTTTTTCTTT
AGATGAAGAATCAATTGTTGAAGTTGATCAGTCTTTAGAAGCCTTCATCCAAGAACAAGATCTAATTCCCGAAATTTTTG
TTTTTACAGGTGGCGATGTCAAAAGAGCAAGCGACGCATATAGAAAAAACATTGGTAACCTAAAACAATCTCTTGAAATA
ATACAAGCCTTTCGTGAAGCACATGAAAAACCACTCAAAGTTATTTCATCGTTACTATCACAATGTTGCGAGCAACTAGA
ACTAAACACTAAACCTGTTAGCAGATTAAAGCGGACTGAAACCATAATAAACAAGCTCCAAAGACCCTCTTTAGATGGAA
AAACCATAAATCAAACATGTGTTAAAAACATGATTGATATTGCTGGATGCCGGCTAATACTTCCAGACATGAACTCGTTA
AATAACATTGCTCAGCATATCGAAAATAGAGTCAATAGTATTAATCGAATCGAAATAAACAAAATAAAAAACTATATAAC
AGATCCTAAAGATAATGATTGTCGATATCGAAGTCTTCATATTCATTTCAAATATAAAACTAAACAAGGAAAACCCTTTA
AGGTTGAAGCTCAATTAAGAACAGAATATCAACATGCTTGGGCTACGACTGTTGAAATTATTGACCTTTTGGAACACACA
AAAATAAAAACGCATTCACACAGCGACTTATATAAAGAAAACCAGCAGAAAAAATGGGAAACGTTGCTCATATTTATGAG
TGATTATATTGCAGATAAAGAAGGAATAATTACATTAAGCGAAGAGGAAAGAAGTTCTATTTCCCTGAGATTAAGCCAGC
TAAATGATGAGCTCCATGCGGCAAGCCATCTGGAATCATTTCAGATGATGACTAAAAAGCTAGAATCAATTATTACAGAT
AATAAAAAACAATATATTTTATTTCTCATTGAAGAAACAGAAAAAAAAGTACTCCTTGAGGAAATATATAACAAAGAAAA
AGAAGCCATAGCACGTTATAATTTAATTGAAAAGGCATTTACAGGTATTGACTCCTTAAATGCCTTACTTGTTTCTTCTG
AAAAAATGAGTTCAATAAACAAGGCATATCCTAACTATGCTGGTGATTGCTCTGAGTTTATCAAGCTTCTAAATGAAGCT
ATCAAATACAAAGATTTATCCTAG

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17656.10 Da        Isoelectric Point: 7.9456

>AT31967 WP_089110283.1 NZ_AP018680:c432285-431818 [Vibrio casei]
MKAYHTYSAIDVAFSLLAHAKKQGKRFTNLQLQKLTYVSHGLSLSHFKRPLIIEDVYAWQYGPVVPSVYFRFKSFGSSVI
TDENDVCLDAESNSIIQDVVTKLGDYSGPQLVELTHRDGSPWKITWDKTPQQIIPDALIQAHYDNIQKTRHTTCL

Download         Length: 468 bp

>AT31967 NZ_AP018680:c432285-431818 [Vibrio casei]
ATGAAAGCTTATCATACCTACAGCGCTATTGACGTAGCGTTTAGCTTGCTCGCCCATGCGAAAAAGCAAGGTAAACGCTT
CACCAATTTACAACTACAAAAGTTAACTTATGTGAGCCACGGTTTATCGCTATCTCATTTTAAGCGACCGCTAATCATTG
AAGATGTATACGCATGGCAGTATGGACCAGTCGTTCCATCTGTTTATTTTAGATTTAAATCTTTTGGTTCATCAGTTATC
ACTGACGAAAATGATGTATGCCTTGATGCGGAAAGCAATAGCATAATTCAGGATGTTGTAACTAAATTGGGCGATTATTC
TGGTCCACAACTTGTTGAACTAACCCATAGAGACGGTAGCCCATGGAAGATCACTTGGGATAAAACACCACAACAAATTA
TTCCTGATGCTTTAATACAAGCACACTATGACAACATCCAAAAAACGAGACATACCACATGCCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References