Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 1593637..1594215 | Replicon | chromosome |
| Accession | NZ_AP018677 | ||
| Organism | Vibrio cholerae strain V060002 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | V060002_RS08145 | Protein ID | WP_001180243.1 |
| Coordinates | 1593898..1594215 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | V060002_RS08140 | Protein ID | WP_000557292.1 |
| Coordinates | 1593637..1593879 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V060002_RS08075 | 1589031..1589477 | - | 447 | WP_000006157.1 | hypothetical protein | - |
| V060002_RS08085 | 1589673..1589711 | - | 39 | WP_106019118.1 | hypothetical protein | - |
| V060002_RS08090 | 1589727..1589852 | - | 126 | WP_001900195.1 | DUF645 family protein | - |
| V060002_RS08095 | 1590245..1590517 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| V060002_RS08100 | 1590514..1591011 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| V060002_RS08105 | 1591161..1591676 | - | 516 | WP_001201509.1 | lipocalin family protein | - |
| V060002_RS08110 | 1591813..1592349 | - | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
| V060002_RS08125 | 1592607..1592888 | - | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
| V060002_RS08130 | 1592837..1592950 | - | 114 | WP_001900214.1 | hypothetical protein | - |
| V060002_RS08135 | 1593007..1593393 | - | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| V060002_RS08140 | 1593637..1593879 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| V060002_RS08145 | 1593898..1594215 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| V060002_RS08155 | 1594369..1594707 | - | 339 | WP_000713853.1 | hypothetical protein | - |
| V060002_RS08160 | 1594865..1595569 | - | 705 | WP_000087610.1 | HNH endonuclease | - |
| V060002_RS08165 | 1595731..1596939 | - | 1209 | WP_000272282.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| V060002_RS08170 | 1597101..1597778 | - | 678 | WP_000254617.1 | HNH endonuclease | - |
| V060002_RS08180 | 1597973..1598155 | - | 183 | WP_000923153.1 | DUF645 family protein | - |
| V060002_RS08185 | 1598509..1598691 | - | 183 | WP_000923340.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 1516275..1622843 | 106568 | |
| - | inside | Integron | - | - | 1566714..1605287 | 38573 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T31965 WP_001180243.1 NZ_AP018677:1593898-1594215 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T31965 NZ_AP018677:1593898-1594215 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT31965 WP_000557292.1 NZ_AP018677:1593637-1593879 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT31965 NZ_AP018677:1593637-1593879 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |