Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1590245..1591011 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag V060002_RS08100 Protein ID WP_000982260.1
Coordinates 1590514..1591011 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag V060002_RS08095 Protein ID WP_000246253.1
Coordinates 1590245..1590517 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS08025 1585742..1585984 - 243 WP_000107461.1 hypothetical protein -
V060002_RS08030 1586076..1586225 - 150 WP_071908333.1 DUF3265 domain-containing protein -
V060002_RS08035 1586198..1586449 - 252 WP_001890111.1 TIGR03643 family protein -
V060002_RS08040 1586644..1587030 - 387 WP_000703163.1 VOC family protein -
V060002_RS08045 1587020..1587121 - 102 WP_001921603.1 hypothetical protein -
V060002_RS08050 1587321..1587527 - 207 Protein_1478 DUF3709 domain-containing protein -
V060002_RS08055 1587779..1588057 - 279 WP_001921601.1 DUF3709 domain-containing protein -
V060002_RS08065 1588343..1588621 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
V060002_RS08070 1588614..1588883 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
V060002_RS08075 1589031..1589477 - 447 WP_000006157.1 hypothetical protein -
V060002_RS08085 1589673..1589711 - 39 WP_106019118.1 hypothetical protein -
V060002_RS08090 1589727..1589852 - 126 WP_001900195.1 DUF645 family protein -
V060002_RS08095 1590245..1590517 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
V060002_RS08100 1590514..1591011 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
V060002_RS08105 1591161..1591676 - 516 WP_001201509.1 lipocalin family protein -
V060002_RS08110 1591813..1592349 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
V060002_RS08125 1592607..1592888 - 282 WP_001894429.1 DUF1289 domain-containing protein -
V060002_RS08130 1592837..1592950 - 114 WP_001900214.1 hypothetical protein -
V060002_RS08135 1593007..1593393 - 387 WP_001015867.1 NUDIX hydrolase -
V060002_RS08140 1593637..1593879 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
V060002_RS08145 1593898..1594215 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
V060002_RS08155 1594369..1594707 - 339 WP_000713853.1 hypothetical protein -
V060002_RS08160 1594865..1595569 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
- inside Integron - - 1566714..1605287 38573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T31964 WP_000982260.1 NZ_AP018677:1590514-1591011 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T31964 NZ_AP018677:1590514-1591011 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT31964 WP_000246253.1 NZ_AP018677:1590245-1590517 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT31964 NZ_AP018677:1590245-1590517 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
PDB 1Y9B
AlphaFold DB A0A0F2IC79

References