31963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1588343..1588883 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag V060002_RS08070 Protein ID WP_000277238.1
Coordinates 1588614..1588883 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag V060002_RS08065 Protein ID WP_001258569.1
Coordinates 1588343..1588621 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS08000 1583923..1584390 - 468 WP_001289288.1 OsmC family protein -
V060002_RS19520 1584602..1584640 - 39 WP_082798268.1 hypothetical protein -
V060002_RS19525 1584694..1584837 - 144 Protein_1471 DUF645 family protein -
V060002_RS08020 1585212..1585490 - 279 WP_000280324.1 DUF3709 domain-containing protein -
V060002_RS08025 1585742..1585984 - 243 WP_000107461.1 hypothetical protein -
V060002_RS08030 1586076..1586225 - 150 WP_071908333.1 DUF3265 domain-containing protein -
V060002_RS08035 1586198..1586449 - 252 WP_001890111.1 TIGR03643 family protein -
V060002_RS08040 1586644..1587030 - 387 WP_000703163.1 VOC family protein -
V060002_RS08045 1587020..1587121 - 102 WP_001921603.1 hypothetical protein -
V060002_RS08050 1587321..1587527 - 207 Protein_1478 DUF3709 domain-containing protein -
V060002_RS08055 1587779..1588057 - 279 WP_001921601.1 DUF3709 domain-containing protein -
V060002_RS08065 1588343..1588621 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
V060002_RS08070 1588614..1588883 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
V060002_RS08075 1589031..1589477 - 447 WP_000006157.1 hypothetical protein -
V060002_RS08085 1589673..1589711 - 39 WP_106019118.1 hypothetical protein -
V060002_RS08090 1589727..1589852 - 126 WP_001900195.1 DUF645 family protein -
V060002_RS08095 1590245..1590517 + 273 WP_000246253.1 DUF1778 domain-containing protein -
V060002_RS08100 1590514..1591011 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
V060002_RS08105 1591161..1591676 - 516 WP_001201509.1 lipocalin family protein -
V060002_RS08110 1591813..1592349 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
V060002_RS08125 1592607..1592888 - 282 WP_001894429.1 DUF1289 domain-containing protein -
V060002_RS08130 1592837..1592950 - 114 WP_001900214.1 hypothetical protein -
V060002_RS08135 1593007..1593393 - 387 WP_001015867.1 NUDIX hydrolase -
V060002_RS08140 1593637..1593879 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
- inside Integron - - 1566714..1605287 38573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T31963 WP_000277238.1 NZ_AP018677:1588614-1588883 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T31963 NZ_AP018677:1588614-1588883 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT31963 WP_001258569.1 NZ_AP018677:1588343-1588621 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT31963 NZ_AP018677:1588343-1588621 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References