31962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1582450..1582948 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag V060002_RS07985 Protein ID WP_000589156.1
Coordinates 1582682..1582948 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag V060002_RS07980 Protein ID WP_000643598.1
Coordinates 1582450..1582695 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS07935 1577698..1578084 - 387 WP_000703163.1 VOC family protein -
V060002_RS07940 1578241..1578747 - 507 WP_000393074.1 hypothetical protein -
V060002_RS07945 1579015..1579287 - 273 WP_119275374.1 DUF3709 domain-containing protein -
V060002_RS07950 1579354..1579713 - 360 WP_001071541.1 VOC family protein -
V060002_RS07955 1579866..1580870 - 1005 WP_000964920.1 LD-carboxypeptidase -
V060002_RS07960 1581086..1581268 - 183 WP_000923182.1 DUF645 family protein -
V060002_RS19570 1581329..1581457 - 129 WP_071908338.1 general secretion pathway protein GspI -
V060002_RS07975 1581560..1582354 - 795 WP_001911581.1 hypothetical protein -
V060002_RS07980 1582450..1582695 - 246 WP_000643598.1 hypothetical protein Antitoxin
V060002_RS07985 1582682..1582948 - 267 WP_000589156.1 BrnT family toxin Toxin
V060002_RS07995 1583133..1583795 - 663 WP_000960654.1 hypothetical protein -
V060002_RS08000 1583923..1584390 - 468 WP_001289288.1 OsmC family protein -
V060002_RS19520 1584602..1584640 - 39 WP_082798268.1 hypothetical protein -
V060002_RS19525 1584694..1584837 - 144 Protein_1471 DUF645 family protein -
V060002_RS08020 1585212..1585490 - 279 WP_000280324.1 DUF3709 domain-containing protein -
V060002_RS08025 1585742..1585984 - 243 WP_000107461.1 hypothetical protein -
V060002_RS08030 1586076..1586225 - 150 WP_071908333.1 DUF3265 domain-containing protein -
V060002_RS08035 1586198..1586449 - 252 WP_001890111.1 TIGR03643 family protein -
V060002_RS08040 1586644..1587030 - 387 WP_000703163.1 VOC family protein -
V060002_RS08045 1587020..1587121 - 102 WP_001921603.1 hypothetical protein -
V060002_RS08050 1587321..1587527 - 207 Protein_1478 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
- inside Integron - - 1566714..1605287 38573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T31962 WP_000589156.1 NZ_AP018677:c1582948-1582682 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T31962 NZ_AP018677:c1582948-1582682 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT31962 WP_000643598.1 NZ_AP018677:c1582695-1582450 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT31962 NZ_AP018677:c1582695-1582450 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References