Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1572432..1572970 | Replicon | chromosome |
| Accession | NZ_AP018677 | ||
| Organism | Vibrio cholerae strain V060002 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | V060002_RS07880 | Protein ID | WP_000802136.1 |
| Coordinates | 1572671..1572970 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | V060002_RS07875 | Protein ID | WP_001107719.1 |
| Coordinates | 1572432..1572674 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V060002_RS07820 | 1567848..1567988 | - | 141 | WP_001883049.1 | DUF3265 domain-containing protein | - |
| V060002_RS07825 | 1567954..1568889 | - | 936 | WP_000051985.1 | restriction endonuclease | - |
| V060002_RS07830 | 1569170..1569769 | - | 600 | WP_000429495.1 | hypothetical protein | - |
| V060002_RS07840 | 1569924..1570190 | - | 267 | WP_000937852.1 | hypothetical protein | - |
| V060002_RS07850 | 1570404..1571087 | - | 684 | WP_000877436.1 | hypothetical protein | - |
| V060002_RS07860 | 1571511..1571603 | - | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
| V060002_RS07865 | 1571625..1572203 | - | 579 | WP_000110120.1 | hypothetical protein | - |
| V060002_RS07875 | 1572432..1572674 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| V060002_RS07880 | 1572671..1572970 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| V060002_RS07885 | 1573098..1573493 | - | 396 | WP_000870857.1 | DUF3465 domain-containing protein | - |
| V060002_RS07890 | 1573707..1573886 | - | 180 | WP_001883058.1 | DUF645 family protein | - |
| V060002_RS07905 | 1574577..1575056 | - | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
| V060002_RS07910 | 1575269..1575892 | - | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
| V060002_RS07915 | 1576098..1576523 | - | 426 | WP_000415750.1 | hypothetical protein | - |
| V060002_RS07920 | 1576670..1576819 | - | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| V060002_RS07925 | 1576792..1577043 | - | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| V060002_RS07930 | 1577238..1577441 | - | 204 | WP_001911580.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 1516275..1622843 | 106568 | |
| - | inside | Integron | - | - | 1566714..1605287 | 38573 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T31961 WP_000802136.1 NZ_AP018677:1572671-1572970 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T31961 NZ_AP018677:1572671-1572970 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT31961 WP_001107719.1 NZ_AP018677:1572432-1572674 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT31961 NZ_AP018677:1572432-1572674 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A | |
| PDB | 7B22 | |
| AlphaFold DB | A0A151JFU4 |