Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 1556669..1557247 | Replicon | chromosome |
| Accession | NZ_AP018677 | ||
| Organism | Vibrio cholerae strain V060002 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | V060002_RS07725 | Protein ID | WP_001180243.1 |
| Coordinates | 1556930..1557247 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | V060002_RS07720 | Protein ID | WP_000557292.1 |
| Coordinates | 1556669..1556911 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V060002_RS07665 | 1552094..1552132 | - | 39 | WP_106019119.1 | hypothetical protein | - |
| V060002_RS07670 | 1552148..1552273 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| V060002_RS19510 | 1552450..1552560 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| V060002_RS07685 | 1552557..1552874 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| V060002_RS07690 | 1552885..1553172 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| V060002_RS07695 | 1553439..1553619 | - | 181 | Protein_1418 | DUF645 family protein | - |
| V060002_RS07700 | 1554044..1554277 | - | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| V060002_RS07705 | 1554680..1554898 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| V060002_RS07710 | 1555208..1555861 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| V060002_RS07715 | 1555918..1556427 | - | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| V060002_RS07720 | 1556669..1556911 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| V060002_RS07725 | 1556930..1557247 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| V060002_RS19515 | 1557441..1557536 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
| V060002_RS19390 | 1557892..1558185 | - | 294 | WP_125460920.1 | hypothetical protein | - |
| V060002_RS07745 | 1558332..1558679 | - | 348 | WP_000933409.1 | hypothetical protein | - |
| V060002_RS07750 | 1558828..1559253 | - | 426 | WP_000403014.1 | GNAT family N-acetyltransferase | - |
| V060002_RS07755 | 1559449..1559628 | - | 180 | WP_001883039.1 | DUF645 family protein | - |
| V060002_RS07760 | 1559925..1560461 | - | 537 | WP_000644491.1 | nucleotidyltransferase family protein | - |
| V060002_RS07765 | 1560605..1561000 | - | 396 | WP_000046953.1 | hypothetical protein | - |
| V060002_RS07770 | 1561177..1561358 | - | 182 | Protein_1432 | DUF645 family protein | - |
| V060002_RS07775 | 1561661..1562056 | - | 396 | WP_000046952.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 1516275..1622843 | 106568 | |
| - | inside | Integron | - | - | 1511738..1563819 | 52081 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T31960 WP_001180243.1 NZ_AP018677:1556930-1557247 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T31960 NZ_AP018677:1556930-1557247 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT31960 WP_000557292.1 NZ_AP018677:1556669-1556911 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT31960 NZ_AP018677:1556669-1556911 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |