31958

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1547302..1547830 Replicon chromosome
Accession NZ_AP018677
Organism Vibrio cholerae strain V060002

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag V060002_RS07630 Protein ID WP_000221352.1
Coordinates 1547540..1547830 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag V060002_RS07625 Protein ID WP_000213183.1
Coordinates 1547302..1547550 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
V060002_RS07575 1542341..1542805 + 465 WP_000140244.1 hypothetical protein -
V060002_RS07580 1542905..1543303 - 399 WP_001882293.1 hypothetical protein -
V060002_RS07590 1543459..1543959 - 501 WP_000789723.1 hypothetical protein -
V060002_RS07595 1544097..1544627 - 531 WP_000415563.1 hypothetical protein -
V060002_RS07600 1544778..1545173 - 396 WP_000649527.1 DUF3465 domain-containing protein -
V060002_RS07605 1545381..1545806 - 426 WP_000415748.1 hypothetical protein -
V060002_RS07610 1546078..1546731 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
V060002_RS07625 1547302..1547550 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
V060002_RS07630 1547540..1547830 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
V060002_RS07635 1547966..1548481 - 516 WP_001201528.1 lipocalin family protein -
V060002_RS07640 1548618..1549094 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
V060002_RS07645 1549122..1549232 - 111 WP_071917832.1 DUF3265 domain-containing protein -
V060002_RS07650 1549229..1550158 - 930 WP_000335802.1 hypothetical protein -
V060002_RS07655 1550278..1550724 - 447 WP_000128977.1 hypothetical protein -
V060002_RS07660 1550877..1551881 - 1005 WP_000964925.1 LD-carboxypeptidase -
V060002_RS07665 1552094..1552132 - 39 WP_106019119.1 hypothetical protein -
V060002_RS07670 1552148..1552273 - 126 WP_001944767.1 DUF645 family protein -
V060002_RS19510 1552450..1552560 - 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 1516275..1622843 106568
- inside Integron - - 1511738..1563819 52081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T31958 WP_000221352.1 NZ_AP018677:1547540-1547830 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T31958 NZ_AP018677:1547540-1547830 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT31958 WP_000213183.1 NZ_AP018677:1547302-1547550 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT31958 NZ_AP018677:1547302-1547550 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References