Detailed information of TA system TA031948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 284630..285243
• Replicon: chromosome
• Accession: NZ_AP018676
• Organism: Helicobacter cinaedi strain P01D0000

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DOM77_RS01430
• Protein ID: WP_104716832.1
• Coordinates: 284630..285031 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I7HE84
• Locus tag: DOM77_RS01435
• Protein ID: WP_002957229.1
• Coordinates: 285019..285243 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOM77_RS01405	281584..283245	-	1662	WP_104716831.1	DUF262 domain-containing HNH endonuclease family protein	-
DOM77_RS11155	283235..283405	-	171	WP_172583174.1	hypothetical protein	-
DOM77_RS01410	283439..283645	-	207	WP_002957235.1	hypothetical protein	-
DOM77_RS01415	283561..283758	-	198	WP_002957234.1	hypothetical protein	-
DOM77_RS01420	283793..283981	-	189	WP_104716838.1	hypothetical protein	-
DOM77_RS01425	284056..284428	-	373	Protein_278	hypothetical protein	-
DOM77_RS01430	284630..285031	-	402	WP_104716832.1	type II toxin-antitoxin system VapC family toxin	Toxin
DOM77_RS01435	285019..285243	-	225	WP_002957229.1	hypothetical protein	Antitoxin
DOM77_RS01440	285406..286317	+	912	WP_104716839.1	WYL domain-containing protein	-
DOM77_RS01445	286460..287134	+	675	WP_002957227.1	hypothetical protein	-
DOM77_RS01450	287183..288553	+	1371	WP_104716833.1	U32 family peptidase	-
DOM77_RS01455	288621..288974	+	354	WP_104716834.1	glycosyltransferase family 2 protein	-
DOM77_RS01460	288895..289998	+	1104	WP_104716835.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15265.83 Da
• Isoelectric Point: 9.2314

>T31948 WP_104716832.1 NZ_AP018676:c285031-284630 [Helicobacter cinaedi]
MAKIMLDTNICIYIINNKPQYIKDRFLQYRIGDIAISSISVAELYFGVEKSQYKEANTNALNTFLTHLKVIDFAHKEALT
YAKIRADLEYKKSLIGAMDMLISAVALANDLTLITNNTKEFQRVKNLKIENWV

Nucleotide

• Length: 402 bp

>T31948 NZ_AP018676:c285031-284630 [Helicobacter cinaedi]
ATGGCAAAAATAATGCTTGATACAAATATATGTATTTATATTATCAATAATAAACCGCAATATATTAAAGATAGATTTTT
ACAATACAGAATAGGCGATATTGCTATAAGCTCTATCAGTGTAGCTGAATTATACTTTGGTGTAGAAAAATCTCAATATA
AAGAAGCAAATACAAATGCTCTTAATACATTCCTAACACACCTTAAAGTCATAGATTTCGCACATAAAGAGGCACTTACA
TATGCAAAAATTAGAGCAGATTTAGAATACAAAAAGTCTCTCATAGGTGCTATGGATATGCTTATTTCAGCGGTAGCTCT
TGCAAATGATTTAACACTTATTACAAATAACACAAAAGAATTTCAAAGAGTTAAGAATCTAAAAATAGAAAATTGGGTGT
GA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8508.80 Da
• Isoelectric Point: 9.9129

>AT31948 WP_002957229.1 NZ_AP018676:c285243-285019 [Helicobacter cinaedi]
MKAKVFKSGNSLAIRLPKALNLTKDCEFNIKQINNNIVLTPANSNWDSLFSAIDSFKGEIKRDELILQDREWQK

Nucleotide

• Length: 225 bp

>AT31948 NZ_AP018676:c285243-285019 [Helicobacter cinaedi]
ATGAAAGCAAAAGTATTTAAAAGTGGTAATTCACTTGCGATAAGATTGCCAAAGGCATTGAATCTTACTAAGGATTGCGA
GTTTAATATAAAACAAATAAATAATAACATTGTTTTAACGCCTGCTAACTCAAATTGGGATAGTCTATTTTCAGCAATAG
ATAGCTTTAAGGGCGAAATAAAGCGAGATGAACTTATATTGCAGGATAGAGAATGGCAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A809NJV2