Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 33738..34297 Replicon plasmid pSAMIE_2
Accession NZ_AP018665
Organism Sphingobium amiense strain DSM 16289

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag SAMIE_RS20440 Protein ID WP_066704026.1
Coordinates 33738..34031 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag SAMIE_RS20445 Protein ID WP_066704024.1
Coordinates 34019..34297 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMIE_RS20410 29180..30775 + 1596 WP_162849111.1 FAD-dependent monooxygenase -
SAMIE_RS20415 31123..31473 - 351 WP_123905555.1 hypothetical protein -
SAMIE_RS20420 31451..31735 - 285 WP_145988141.1 TetR/AcrR family transcriptional regulator -
SAMIE_RS20425 31748..32116 + 369 WP_066704032.1 CopG family transcriptional regulator -
SAMIE_RS20430 32122..33102 + 981 WP_066704038.1 tyrosine-type recombinase/integrase -
SAMIE_RS20435 33099..33719 - 621 WP_066704029.1 phosphoglycerate mutase family protein -
SAMIE_RS20440 33738..34031 - 294 WP_066704026.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SAMIE_RS20445 34019..34297 - 279 WP_066704024.1 CopG family ribbon-helix-helix protein Antitoxin
SAMIE_RS20450 34837..35478 + 642 WP_066704021.1 transcription elongation protein SprT -
SAMIE_RS20455 35558..36193 + 636 WP_066704017.1 AAA family ATPase -
SAMIE_RS20460 36219..36500 + 282 WP_066704014.1 hypothetical protein -
SAMIE_RS20465 36557..37468 - 912 WP_066704011.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..212396 212396
- flank IS/Tn - - 37776..39872 2096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10846.42 Da        Isoelectric Point: 9.4809

>T31924 WP_066704026.1 NZ_AP018665:c34031-33738 [Sphingobium amiense]
VPRLIWTANALNNVDRLHRWLKPKDADAARRAVAAIRGGVKILATSPHIGRPAEDMDPEYREKLIDFGDSGYVVLYRLDG
EAVTLLAVRHQKEAGYP

Download         Length: 294 bp

>T31924 NZ_AP018665:c34031-33738 [Sphingobium amiense]
GTGCCACGTCTGATCTGGACGGCGAACGCGCTGAATAATGTTGACCGGCTGCATCGCTGGTTGAAGCCCAAGGATGCGGA
CGCCGCGCGCCGCGCGGTCGCAGCGATCCGGGGAGGGGTCAAGATTCTGGCGACATCGCCGCACATCGGGCGGCCTGCGG
AAGATATGGACCCCGAATATCGGGAAAAGCTGATCGACTTTGGAGATAGCGGCTATGTCGTCCTCTATCGCCTCGATGGC
GAGGCGGTGACGCTGCTGGCGGTTCGCCACCAAAAGGAGGCCGGCTATCCGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10605.88 Da        Isoelectric Point: 5.1991

>AT31924 WP_066704024.1 NZ_AP018665:c34297-34019 [Sphingobium amiense]
MAAATSIKLDDSLKGRVQHLADARRRSSHWIMREAITQYVDREEKREAFKQEAIQAWEEYQQTGLHVTLEEADAWLAKLE
AGEDAELPKCHV

Download         Length: 279 bp

>AT31924 NZ_AP018665:c34297-34019 [Sphingobium amiense]
ATGGCGGCGGCAACATCTATCAAGCTGGACGATAGCCTGAAAGGGCGAGTGCAACACTTGGCCGACGCGCGCCGGCGCAG
CTCGCATTGGATCATGCGCGAGGCCATCACGCAGTATGTCGATCGCGAGGAAAAGCGCGAGGCGTTCAAGCAGGAAGCCA
TACAGGCATGGGAGGAATATCAGCAGACCGGCTTGCATGTGACGCTTGAGGAAGCCGACGCCTGGTTGGCGAAGCTGGAA
GCGGGCGAGGACGCGGAACTACCTAAGTGCCACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References