Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2120793..2121269 Replicon chromosome
Accession NZ_AP018587
Organism Staphylococcus caprae strain JMUB898

Toxin (Protein)


Gene name TsaT Uniprot ID C5QQH5
Locus tag JMUB898_RS10195 Protein ID WP_002441631.1
Coordinates 2121081..2121269 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID C5QQH6
Locus tag JMUB898_RS10190 Protein ID WP_002441634.1
Coordinates 2120793..2121050 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB898_RS10155 2116016..2116738 - 723 WP_002441649.1 type I 3-dehydroquinate dehydratase -
JMUB898_RS10160 2116908..2117330 + 423 WP_002441647.1 organic hydroperoxide resistance protein -
JMUB898_RS10165 2117725..2118231 + 507 WP_002441644.1 GNAT family N-acetyltransferase -
JMUB898_RS10170 2118429..2119049 + 621 WP_002441642.1 LysE family transporter -
JMUB898_RS10175 2119111..2119695 - 585 WP_037541214.1 phosphoglycerate mutase family protein -
JMUB898_RS10180 2119919..2120155 + 237 WP_002441638.1 hypothetical protein -
JMUB898_RS10185 2120147..2120350 - 204 WP_002441635.1 sterile alpha motif-like domain-containing protein -
JMUB898_RS10190 2120793..2121050 + 258 WP_002441634.1 hypothetical protein Antitoxin
JMUB898_RS10195 2121081..2121269 + 189 WP_002441631.1 hypothetical protein Toxin
JMUB898_RS10200 2121495..2122079 + 585 WP_037541212.1 orthopoxovirus protein, PF05708 family -
JMUB898_RS10205 2122143..2122376 - 234 WP_002441627.1 hypothetical protein -
JMUB898_RS10210 2122518..2123123 - 606 WP_002441625.1 GNAT family N-acetyltransferase -
JMUB898_RS10215 2123304..2124050 + 747 WP_044466334.1 poly-gamma-glutamate hydrolase family protein -
JMUB898_RS10220 2124171..2124455 + 285 WP_002441619.1 hypothetical protein -
JMUB898_RS10225 2124484..2124702 + 219 WP_002441617.1 hypothetical protein -
JMUB898_RS10230 2125004..2125330 + 327 WP_002441615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7214.94 Da        Isoelectric Point: 9.7844

>T31920 WP_002441631.1 NZ_AP018587:2121081-2121269 [Staphylococcus caprae]
MNLHFQILLWLSIIFIVAGAIILAIMLKTKKEERKESYLGFTVIFLIFGFAMLIYTFIFGIL

Download         Length: 189 bp

>T31920 NZ_AP018587:2121081-2121269 [Staphylococcus caprae]
ATGAATTTACATTTTCAAATATTATTATGGCTTTCAATTATATTCATTGTTGCTGGTGCAATTATTTTAGCCATTATGCT
TAAAACGAAAAAAGAAGAGAGAAAAGAATCTTATTTAGGTTTTACGGTTATTTTCTTAATTTTCGGCTTTGCAATGCTCA
TTTATACATTTATTTTTGGTATATTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.80 Da        Isoelectric Point: 4.0612

>AT31920 WP_002441634.1 NZ_AP018587:2120793-2121050 [Staphylococcus caprae]
MKIISVNVINIILTVLFIAFNVLITYNANVDNHLWLIPGLCICGIALFTSLTIAIIYTDLLSEILFFINIVLALYYIYPI
FYDFL

Download         Length: 258 bp

>AT31920 NZ_AP018587:2120793-2121050 [Staphylococcus caprae]
ATGAAAATAATTAGTGTAAATGTGATTAATATCATCTTAACCGTACTATTTATAGCTTTTAATGTACTCATTACCTATAA
TGCAAACGTTGATAATCACCTATGGTTAATACCAGGATTATGTATTTGTGGTATTGCTCTATTTACGAGTTTAACAATAG
CAATTATTTATACTGATCTTTTAAGTGAAATTTTGTTCTTTATTAATATTGTCTTAGCACTTTACTATATTTATCCAATT
TTTTATGACTTCCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1GRH8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GRF3

References