Detailed information of TA system TA031919

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1094546..1095349
• Replicon: chromosome
• Accession: NZ_AP018587
• Organism: Staphylococcus caprae strain JMUB898

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: C5QTI8
• Locus tag: JMUB898_RS05330
• Protein ID: WP_002443566.1
• Coordinates: 1095170..1095349 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: JMUB898_RS05325
• Protein ID: WP_037541523.1
• Coordinates: 1094546..1095145 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMUB898_RS05305	1090434..1091891	+	1458	WP_044466434.1	ABC transporter substrate-binding protein/permease	-
JMUB898_RS05310	1091884..1092606	+	723	WP_002443573.1	amino acid ABC transporter ATP-binding protein	-
JMUB898_RS05315	1092766..1093893	+	1128	WP_002443571.1	tRNA epoxyqueuosine(34) reductase QueG	-
JMUB898_RS05320	1093896..1094366	+	471	WP_002443570.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JMUB898_RS05325	1094546..1095145	+	600	WP_037541523.1	glucosamine-6-phosphate isomerase	Antitoxin
JMUB898_RS05330	1095170..1095349	+	180	WP_002443566.1	hypothetical protein	Toxin
JMUB898_RS05335	1095585..1095983	+	399	WP_002443564.1	hypothetical protein	-
JMUB898_RS05340	1096136..1097521	+	1386	WP_002443562.1	class II fumarate hydratase	-
JMUB898_RS05345	1097621..1098448	-	828	WP_002443561.1	RluA family pseudouridine synthase	-
JMUB898_RS05350	1098627..1099739	+	1113	WP_002443558.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6967.41 Da
• Isoelectric Point: 3.9152

>T31919 WP_002443566.1 NZ_AP018587:1095170-1095349 [Staphylococcus caprae]
MAKEQESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVRSDLQDK

Nucleotide

• Length: 180 bp

>T31919 NZ_AP018587:1095170-1095349 [Staphylococcus caprae]
ATGGCTAAAGAACAAGAATCTAAATTGAATTATCATGAAGAAGAAAATGCAATGGTGACAGATTTAGATGATTTGAAAGA
ATTAGGTAAAGAAATGGAGCAAATTTCAGAAGAGAATGATGAAGACAAACTGAATCAATCTCATGACGAAGACGTACGTT
CCGACCTACAAGATAAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22694.63 Da
• Isoelectric Point: 4.7838

>AT31919 WP_037541523.1 NZ_AP018587:1094546-1095145 [Staphylococcus caprae]
MAMNFKVFDNNERVAEYAADIIRKQFNNNPTTIAGFHLDKDQAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEKDAIEFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKRDVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFV

Nucleotide

• Length: 600 bp

>AT31919 NZ_AP018587:1094546-1095145 [Staphylococcus caprae]
ATGGCAATGAACTTTAAAGTATTTGATAATAATGAAAGAGTAGCAGAATACGCTGCTGATATTATTCGTAAACAATTTAA
TAACAATCCTACAACAATTGCAGGATTTCATTTAGACAAGGACCAAGCGCCTGTTTTAGATGAACTTAAGAAAAACGTTG
ATACACACGCTGTAGACTTTAGTCAAATCAATATCTTAGATTATGACGACAATCGCTCTTATTATGAAGCTTTAGGAGTA
CCTGAAAGTCAAGTTTATTCAATCTCTTATGAAAAAGATGCAATTGAATTTATCTCAGATAAAATGAAAACGAAAGAAAA
TAAAGGAAAATTAATCCTTCAAGTTCTTTCTATAGATGAAAGTGGCAAATTAGATGTTAGCGTACGACAAGGTTTAATGG
AAGCTAGAGAAATCTTCTTAGTAGTCACTGGTAGCAATAAACGTGATGTGATTGAGAAATTATATCGTGAAAATGGTAAA
TCTAGTTATGAACCAGCAGATTTAAAAGCACATCGTATGGTTAATGTTATCTTAGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGACGTTAAAGAGTACTTCACAGCACGTTTTGTCTAA

Structures

Toxin

• AlphaFold DB: A0A1J3ZT52