Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 925998..926527 Replicon chromosome
Accession NZ_AP018587
Organism Staphylococcus caprae strain JMUB898

Toxin (Protein)


Gene name mazF Uniprot ID C5QLA1
Locus tag JMUB898_RS04375 Protein ID WP_002445525.1
Coordinates 926165..926527 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1S1GX41
Locus tag JMUB898_RS04370 Protein ID WP_037541853.1
Coordinates 925998..926168 (+) Length 57 a.a.

Genomic Context

JMUB898_RS04345JMUB898_RS04350JMUB898_RS04355JMUB898_RS04360JMUB898_RS04365JMUB898_RS04370JMUB898_RS04375JMUB898_RS04380JMUB898_RS04385JMUB898_RS04390JMUB898_RS04395
Location: 921813..922292 (480 bp)
Type: Others
Protein ID: WP_044466354.1
Location: 922285..923784 (1500 bp)
Type: Others
Protein ID: WP_044466353.1
Location: 923771..924313 (543 bp)
Type: Others
Protein ID: WP_044466352.1
Location: 924328..924684 (357 bp)
Type: Others
Protein ID: WP_044466351.1
Location: 924762..925910 (1149 bp)
Type: Others
Protein ID: WP_002445529.1
Location: 925998..926168 (171 bp)
Type: Antitoxin
Protein ID: WP_037541853.1
Location: 926165..926527 (363 bp)
Type: Toxin
Protein ID: WP_002445525.1
Location: 926899..927900 (1002 bp)
Type: Others
Protein ID: WP_044466350.1
Location: 928003..928329 (327 bp)
Type: Others
Protein ID: WP_037541852.1
Location: 928331..928810 (480 bp)
Type: Others
Protein ID: WP_002445522.1
Location: 928785..929555 (771 bp)
Type: Others
Protein ID: WP_002445521.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JMUB898_RS04345921813..922292+480WP_044466354.1PH domain-containing protein-
JMUB898_RS04350922285..923784+1500WP_044466353.1PH domain-containing protein-
JMUB898_RS04355923771..924313+543WP_044466352.1PH domain-containing protein-
JMUB898_RS04360924328..924684+357WP_044466351.1holo-ACP synthase-
JMUB898_RS04365924762..925910+1149WP_002445529.1alanine racemase-
JMUB898_RS04370925998..926168+171WP_037541853.1hypothetical proteinAntitoxin
JMUB898_RS04375926165..926527+363WP_002445525.1type II toxin-antitoxin system PemK/MazF family toxinToxin
JMUB898_RS04380926899..927900+1002WP_044466350.1PP2C family protein-serine/threonine phosphatase-
JMUB898_RS04385928003..928329+327WP_037541852.1anti-sigma factor antagonist-
JMUB898_RS04390928331..928810+480WP_002445522.1anti-sigma B factor RsbW-
JMUB898_RS04395928785..929555+771WP_002445521.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13511.68 Da        Isoelectric Point: 10.0250

>T31918 WP_002445525.1 NZ_AP018587:926165-926527 [Staphylococcus caprae]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHPKS

Download         Length: 363 bp

>T31918 NZ_AP018587:926165-926527 [Staphylococcus caprae]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTGCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTCGT
TATTATTCAAAACGATACTGGTAATAAATATAGTCCTACAGTCATTGTGGCTGCTATTACAGGTAGGATTAATAAAGCGA
AAATACCAACCCATGTAGAAATTGAAAAGAAAAAGTACAAGTTAGATAAAGATTCCGTTATCCTACTTGAACAAATTAGA
ACACTTGATAAAAAACGATTAAAAGAAAAATTGACCTATTTATCTGAAAGTAAGATGAAAGAGGTCGACAACGCCCTAGA
CATTAGTCTAGGCTTACATAACTTTGATCATCCAAAATCATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6290.90 Da        Isoelectric Point: 4.0121

>AT31918 WP_037541853.1 NZ_AP018587:925998-926168 [Staphylococcus caprae]
MLSFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT31918 NZ_AP018587:925998-926168 [Staphylococcus caprae]
ATGTTATCTTTTAATCAAAATAGAAGTCACAGTCTTGAACAATCCTTAAAAGAAGGTTATGCACAAATGGCTGATCTAAA
CCTCTCCCTAGCGACGGAAGCTTTCCCGATTGAGTGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1S1GUI8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1S1GX41

References