Detailed information of TA system TA031917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 914707..915220
• Replicon: chromosome
• Accession: NZ_AP018587
• Organism: Staphylococcus caprae strain JMUB898

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: JMUB898_RS04315
• Protein ID: WP_172594642.1
• Coordinates: 915068..915220 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A1S1GSV6
• Locus tag: JMUB898_RS04310
• Protein ID: WP_037541856.1
• Coordinates: 914707..915000 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMUB898_RS04285	909883..910677	+	795	WP_002445553.1	hydroxyethylthiazole kinase	-
JMUB898_RS04290	910678..911316	+	639	WP_002445552.1	thiamine phosphate synthase	-
JMUB898_RS04295	911405..912274	+	870	WP_044466357.1	membrane protein insertase YidC	-
JMUB898_RS04300	912341..912991	-	651	WP_044466356.1	HD domain-containing protein	-
JMUB898_RS04305	913051..914535	-	1485	WP_126501916.1	cardiolipin synthase	-
JMUB898_RS04310	914707..915000	+	294	WP_037541856.1	copper-sensing transcriptional repressor CsoR	Antitoxin
JMUB898_RS04315	915068..915220	+	153	WP_172594642.1	heavy-metal-associated domain-containing protein	Toxin
JMUB898_RS04320	915356..915493	+	138	WP_002445543.1	hypothetical protein	-
JMUB898_RS04325	915550..916761	-	1212	WP_126501917.1	rod shape-determining protein RodA	-
JMUB898_RS04330	917408..918478	+	1071	WP_037541855.1	D-alanine--D-alanine ligase	-
JMUB898_RS04335	918494..919849	+	1356	WP_002445538.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5770.63 Da
• Isoelectric Point: 4.2898

>T31917 WP_172594642.1 NZ_AP018587:915068-915220 [Staphylococcus caprae]
MLMERLQNMIGVYNVAIDSKVGEIKVEFDTPANLNSIEKEVYDSGYRILY

Nucleotide

• Length: 153 bp

>T31917 NZ_AP018587:915068-915220 [Staphylococcus caprae]
ATGCTAATGGAACGTTTACAAAACATGATTGGCGTTTATAATGTGGCAATTGATAGTAAAGTAGGAGAAATAAAAGTCGA
GTTTGATACGCCTGCGAATTTAAATAGTATCGAAAAAGAGGTATATGATTCAGGTTATCGAATATTATATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11078.60 Da
• Isoelectric Point: 6.8620

>AT31917 WP_037541856.1 NZ_AP018587:914707-915000 [Staphylococcus caprae]
VTENEKAHHSDQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT31917 NZ_AP018587:914707-915000 [Staphylococcus caprae]
GTGACTGAAAATGAAAAAGCACATCATTCAGATCAAACAAAAGCAAATTTAAAATCACGTTTAAACCGAATAGAAGGGCA
AGTTAGAGCAATTAATCGCATGATTGAAGACGACGTTTATTGTGATGATGTTTTAACTCAAATAAGAGCAACACGTTCAG
CACTCAATAGTGTAGCAACCAAGTTACTCGATCATCATATGAAAAGTTGTATCATGAACAAAGTGAACAATGGTGCACAA
GAAGAAGCAATGGAAGAATTATTAGTTACCTTTCAAAAATTAATTAAAGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S1GSV6