31915

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2137007..2137483 Replicon chromosome
Accession NZ_AP018586
Organism Staphylococcus caprae strain JMUB590

Toxin (Protein)


Gene name TsaT Uniprot ID C5QQH5
Locus tag EL289_RS10250 Protein ID WP_002441631.1
Coordinates 2137295..2137483 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID C5QQH6
Locus tag EL289_RS10245 Protein ID WP_002441634.1
Coordinates 2137007..2137264 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL289_RS10210 2132230..2132952 - 723 WP_002441649.1 type I 3-dehydroquinate dehydratase -
EL289_RS10215 2133122..2133544 + 423 WP_002441647.1 organic hydroperoxide resistance protein -
EL289_RS10220 2133939..2134445 + 507 WP_002441644.1 GNAT family N-acetyltransferase -
EL289_RS10225 2134643..2135263 + 621 WP_002441642.1 LysE family transporter -
EL289_RS10230 2135325..2135909 - 585 WP_037541214.1 phosphoglycerate mutase family protein -
EL289_RS10235 2136133..2136369 + 237 WP_002441638.1 hypothetical protein -
EL289_RS10240 2136361..2136564 - 204 WP_002441635.1 sterile alpha motif-like domain-containing protein -
EL289_RS10245 2137007..2137264 + 258 WP_002441634.1 hypothetical protein Antitoxin
EL289_RS10250 2137295..2137483 + 189 WP_002441631.1 hypothetical protein Toxin
EL289_RS10255 2137709..2138293 + 585 WP_037541212.1 orthopoxovirus protein, PF05708 family -
EL289_RS10260 2138357..2138590 - 234 WP_002441627.1 hypothetical protein -
EL289_RS10265 2138732..2139337 - 606 WP_002441625.1 GNAT family N-acetyltransferase -
EL289_RS10270 2139518..2140264 + 747 WP_044466334.1 poly-gamma-glutamate hydrolase family protein -
EL289_RS10275 2140385..2140669 + 285 WP_002441619.1 hypothetical protein -
EL289_RS10280 2140698..2140916 + 219 WP_002441617.1 hypothetical protein -
EL289_RS10285 2141218..2141544 + 327 WP_002441615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7214.94 Da        Isoelectric Point: 9.7844

>T31915 WP_002441631.1 NZ_AP018586:2137295-2137483 [Staphylococcus caprae]
MNLHFQILLWLSIIFIVAGAIILAIMLKTKKEERKESYLGFTVIFLIFGFAMLIYTFIFGIL

Download         Length: 189 bp

>T31915 NZ_AP018586:2137295-2137483 [Staphylococcus caprae]
ATGAATTTACATTTTCAAATATTATTATGGCTTTCAATTATATTCATTGTTGCTGGTGCAATTATTTTAGCCATTATGCT
TAAAACGAAAAAAGAAGAGAGAAAAGAATCTTATTTAGGTTTTACGGTTATTTTCTTAATTTTCGGCTTTGCAATGCTCA
TTTATACATTTATTTTTGGTATATTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.80 Da        Isoelectric Point: 4.0612

>AT31915 WP_002441634.1 NZ_AP018586:2137007-2137264 [Staphylococcus caprae]
MKIISVNVINIILTVLFIAFNVLITYNANVDNHLWLIPGLCICGIALFTSLTIAIIYTDLLSEILFFINIVLALYYIYPI
FYDFL

Download         Length: 258 bp

>AT31915 NZ_AP018586:2137007-2137264 [Staphylococcus caprae]
ATGAAAATAATTAGTGTAAATGTGATTAATATCATCTTAACCGTACTATTTATAGCTTTTAATGTACTCATTACCTATAA
TGCAAACGTTGATAATCACCTATGGTTAATACCAGGATTATGTATTTGTGGTATTGCTCTATTTACGAGTTTAACAATAG
CAATTATTTATACTGATCTTTTAAGTGAAATTTTGTTCTTTATTAATATTGTCTTAGCACTTTACTATATTTATCCAATT
TTTTATGACTTCCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1GRH8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GRF3

References