Detailed information of TA system TA031914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1109377..1110180
• Replicon: chromosome
• Accession: NZ_AP018586
• Organism: Staphylococcus caprae strain JMUB590

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: C5QTI8
• Locus tag: EL289_RS05380
• Protein ID: WP_002443566.1
• Coordinates: 1110001..1110180 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: EL289_RS05375
• Protein ID: WP_037541523.1
• Coordinates: 1109377..1109976 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL289_RS05355	1105265..1106722	+	1458	WP_044466434.1	ABC transporter substrate-binding protein/permease	-
EL289_RS05360	1106715..1107437	+	723	WP_002443573.1	amino acid ABC transporter ATP-binding protein	-
EL289_RS05365	1107597..1108724	+	1128	WP_002443571.1	tRNA epoxyqueuosine(34) reductase QueG	-
EL289_RS05370	1108727..1109197	+	471	WP_002443570.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
EL289_RS05375	1109377..1109976	+	600	WP_037541523.1	glucosamine-6-phosphate isomerase	Antitoxin
EL289_RS05380	1110001..1110180	+	180	WP_002443566.1	hypothetical protein	Toxin
EL289_RS05385	1110416..1110814	+	399	WP_002443564.1	hypothetical protein	-
EL289_RS05390	1110967..1112352	+	1386	WP_002443562.1	class II fumarate hydratase	-
EL289_RS05395	1112452..1113279	-	828	WP_002443561.1	RluA family pseudouridine synthase	-
EL289_RS05400	1113458..1114570	+	1113	WP_002443558.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6967.41 Da
• Isoelectric Point: 3.9152

>T31914 WP_002443566.1 NZ_AP018586:1110001-1110180 [Staphylococcus caprae]
MAKEQESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVRSDLQDK

Nucleotide

• Length: 180 bp

>T31914 NZ_AP018586:1110001-1110180 [Staphylococcus caprae]
ATGGCTAAAGAACAAGAATCTAAATTGAATTATCATGAAGAAGAAAATGCAATGGTGACAGATTTAGATGATTTGAAAGA
ATTAGGTAAAGAAATGGAGCAAATTTCAGAAGAGAATGATGAAGACAAACTGAATCAATCTCATGACGAAGACGTACGTT
CCGACCTACAAGATAAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22694.63 Da
• Isoelectric Point: 4.7838

>AT31914 WP_037541523.1 NZ_AP018586:1109377-1109976 [Staphylococcus caprae]
MAMNFKVFDNNERVAEYAADIIRKQFNNNPTTIAGFHLDKDQAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEKDAIEFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKRDVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFV

Nucleotide

• Length: 600 bp

>AT31914 NZ_AP018586:1109377-1109976 [Staphylococcus caprae]
ATGGCAATGAACTTTAAAGTATTTGATAATAATGAAAGAGTAGCAGAATACGCTGCTGATATTATTCGTAAACAATTTAA
TAACAATCCTACAACAATTGCAGGATTTCATTTAGACAAGGACCAAGCGCCTGTTTTAGATGAACTTAAGAAAAACGTTG
ATACACACGCTGTAGACTTTAGTCAAATCAATATCTTAGATTATGACGACAATCGCTCTTATTATGAAGCTTTAGGAGTA
CCTGAAAGTCAAGTTTATTCAATCTCTTATGAAAAAGATGCAATTGAATTTATCTCAGATAAAATGAAAACGAAAGAAAA
TAAAGGAAAATTAATCCTTCAAGTTCTTTCTATAGATGAAAGTGGCAAATTAGATGTTAGCGTACGACAAGGTTTAATGG
AAGCTAGAGAAATCTTCTTAGTAGTCACTGGTAGCAATAAACGTGATGTGATTGAGAAATTATATCGTGAAAATGGTAAA
TCTAGTTATGAACCAGCAGATTTAAAAGCACATCGTATGGTTAATGTTATCTTAGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGACGTTAAAGAGTACTTCACAGCACGTTTTGTCTAA

Structures

Toxin

• AlphaFold DB: A0A1J3ZT52