Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 940491..941020 Replicon chromosome
Accession NZ_AP018586
Organism Staphylococcus caprae strain JMUB590

Toxin (Protein)


Gene name mazF Uniprot ID C5QLA1
Locus tag EL289_RS04425 Protein ID WP_002445525.1
Coordinates 940658..941020 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1S1GX41
Locus tag EL289_RS04420 Protein ID WP_037541853.1
Coordinates 940491..940661 (+) Length 57 a.a.

Genomic Context

EL289_RS04395EL289_RS04400EL289_RS04405EL289_RS04410EL289_RS04415EL289_RS04420EL289_RS04425EL289_RS04430EL289_RS04435EL289_RS04440EL289_RS04445
Location: 936306..936785 (480 bp)
Type: Others
Protein ID: WP_044466354.1
Location: 936778..938277 (1500 bp)
Type: Others
Protein ID: WP_044466353.1
Location: 938264..938806 (543 bp)
Type: Others
Protein ID: WP_044466352.1
Location: 938821..939177 (357 bp)
Type: Others
Protein ID: WP_044466351.1
Location: 939255..940403 (1149 bp)
Type: Others
Protein ID: WP_002445529.1
Location: 940491..940661 (171 bp)
Type: Antitoxin
Protein ID: WP_037541853.1
Location: 940658..941020 (363 bp)
Type: Toxin
Protein ID: WP_002445525.1
Location: 941392..942393 (1002 bp)
Type: Others
Protein ID: WP_044466350.1
Location: 942496..942822 (327 bp)
Type: Others
Protein ID: WP_037541852.1
Location: 942824..943303 (480 bp)
Type: Others
Protein ID: WP_002445522.1
Location: 943278..944048 (771 bp)
Type: Others
Protein ID: WP_002445521.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL289_RS04395936306..936785+480WP_044466354.1PH domain-containing protein-
EL289_RS04400936778..938277+1500WP_044466353.1PH domain-containing protein-
EL289_RS04405938264..938806+543WP_044466352.1PH domain-containing protein-
EL289_RS04410938821..939177+357WP_044466351.1holo-ACP synthase-
EL289_RS04415939255..940403+1149WP_002445529.1alanine racemase-
EL289_RS04420940491..940661+171WP_037541853.1hypothetical proteinAntitoxin
EL289_RS04425940658..941020+363WP_002445525.1type II toxin-antitoxin system PemK/MazF family toxinToxin
EL289_RS04430941392..942393+1002WP_044466350.1PP2C family protein-serine/threonine phosphatase-
EL289_RS04435942496..942822+327WP_037541852.1anti-sigma factor antagonist-
EL289_RS04440942824..943303+480WP_002445522.1anti-sigma B factor RsbW-
EL289_RS04445943278..944048+771WP_002445521.1RNA polymerase sigma factor SigB-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13511.68 Da        Isoelectric Point: 10.0250

>T31913 WP_002445525.1 NZ_AP018586:940658-941020 [Staphylococcus caprae]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHPKS

Download         Length: 363 bp

>T31913 NZ_AP018586:940658-941020 [Staphylococcus caprae]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTGCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTCGT
TATTATTCAAAACGATACTGGTAATAAATATAGTCCTACAGTCATTGTGGCTGCTATTACAGGTAGGATTAATAAAGCGA
AAATACCAACCCATGTAGAAATTGAAAAGAAAAAGTACAAGTTAGATAAAGATTCCGTTATCCTACTTGAACAAATTAGA
ACACTTGATAAAAAACGATTAAAAGAAAAATTGACCTATTTATCTGAAAGTAAGATGAAAGAGGTCGACAACGCCCTAGA
CATTAGTCTAGGCTTACATAACTTTGATCATCCAAAATCATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6290.90 Da        Isoelectric Point: 4.0121

>AT31913 WP_037541853.1 NZ_AP018586:940491-940661 [Staphylococcus caprae]
MLSFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT31913 NZ_AP018586:940491-940661 [Staphylococcus caprae]
ATGTTATCTTTTAATCAAAATAGAAGTCACAGTCTTGAACAATCCTTAAAAGAAGGTTATGCACAAATGGCTGATCTAAA
CCTCTCCCTAGCGACGGAAGCTTTCCCGATTGAGTGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1S1GUI8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1S1GX41

References