Detailed information of TA system TA031912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 929200..929713
• Replicon: chromosome
• Accession: NZ_AP018586
• Organism: Staphylococcus caprae strain JMUB590

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: EL289_RS04365
• Protein ID: WP_172594642.1
• Coordinates: 929561..929713 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A1S1GSV6
• Locus tag: EL289_RS04360
• Protein ID: WP_037541856.1
• Coordinates: 929200..929493 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL289_RS04335	924376..925170	+	795	WP_002445553.1	hydroxyethylthiazole kinase	-
EL289_RS04340	925171..925809	+	639	WP_002445552.1	thiamine phosphate synthase	-
EL289_RS04345	925898..926767	+	870	WP_044466357.1	membrane protein insertase YidC	-
EL289_RS04350	926834..927484	-	651	WP_044466356.1	HD domain-containing protein	-
EL289_RS04355	927544..929028	-	1485	WP_126501916.1	cardiolipin synthase	-
EL289_RS04360	929200..929493	+	294	WP_037541856.1	copper-sensing transcriptional repressor CsoR	Antitoxin
EL289_RS04365	929561..929713	+	153	WP_172594642.1	heavy-metal-associated domain-containing protein	Toxin
EL289_RS04370	929849..929986	+	138	WP_002445543.1	hypothetical protein	-
EL289_RS04375	930043..931254	-	1212	WP_126501917.1	rod shape-determining protein RodA	-
EL289_RS04380	931901..932971	+	1071	WP_037541855.1	D-alanine--D-alanine ligase	-
EL289_RS04385	932987..934342	+	1356	WP_002445538.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5770.63 Da
• Isoelectric Point: 4.2898

>T31912 WP_172594642.1 NZ_AP018586:929561-929713 [Staphylococcus caprae]
MLMERLQNMIGVYNVAIDSKVGEIKVEFDTPANLNSIEKEVYDSGYRILY

Nucleotide

• Length: 153 bp

>T31912 NZ_AP018586:929561-929713 [Staphylococcus caprae]
ATGCTAATGGAACGTTTACAAAACATGATTGGCGTTTATAATGTGGCAATTGATAGTAAAGTAGGAGAAATAAAAGTCGA
GTTTGATACGCCTGCGAATTTAAATAGTATCGAAAAAGAGGTATATGATTCAGGTTATCGAATATTATATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11078.60 Da
• Isoelectric Point: 6.8620

>AT31912 WP_037541856.1 NZ_AP018586:929200-929493 [Staphylococcus caprae]
VTENEKAHHSDQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT31912 NZ_AP018586:929200-929493 [Staphylococcus caprae]
GTGACTGAAAATGAAAAAGCACATCATTCAGATCAAACAAAAGCAAATTTAAAATCACGTTTAAACCGAATAGAAGGGCA
AGTTAGAGCAATTAATCGCATGATTGAAGACGACGTTTATTGTGATGATGTTTTAACTCAAATAAGAGCAACACGTTCAG
CACTCAATAGTGTAGCAACCAAGTTACTCGATCATCATATGAAAAGTTGTATCATGAACAAAGTGAACAATGGTGCACAA
GAAGAAGCAATGGAAGAATTATTAGTTACCTTTCAAAAATTAATTAAAGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S1GSV6