31910

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2132682..2133158 Replicon chromosome
Accession NZ_AP018585
Organism Staphylococcus caprae strain JMUB145

Toxin (Protein)


Gene name TsaT Uniprot ID C5QQH5
Locus tag EL290_RS10195 Protein ID WP_002441631.1
Coordinates 2132970..2133158 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID C5QQH6
Locus tag EL290_RS10190 Protein ID WP_002441634.1
Coordinates 2132682..2132939 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL290_RS10160 2128255..2129427 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
EL290_RS10165 2129614..2130120 + 507 WP_002441644.1 GNAT family N-acetyltransferase -
EL290_RS10170 2130318..2130938 + 621 WP_002441642.1 LysE family transporter -
EL290_RS10175 2131000..2131584 - 585 WP_037541214.1 phosphoglycerate mutase family protein -
EL290_RS10180 2131808..2132044 + 237 WP_002441638.1 hypothetical protein -
EL290_RS10185 2132036..2132239 - 204 WP_126493844.1 sterile alpha motif-like domain-containing protein -
EL290_RS10190 2132682..2132939 + 258 WP_002441634.1 hypothetical protein Antitoxin
EL290_RS10195 2132970..2133158 + 189 WP_002441631.1 hypothetical protein Toxin
EL290_RS10200 2133384..2133968 + 585 WP_037541212.1 orthopoxovirus protein, PF05708 family -
EL290_RS10205 2134032..2134265 - 234 WP_002441627.1 hypothetical protein -
EL290_RS10210 2134407..2135012 - 606 WP_002441625.1 GNAT family N-acetyltransferase -
EL290_RS10215 2135193..2135939 + 747 WP_044466334.1 poly-gamma-glutamate hydrolase family protein -
EL290_RS10220 2136060..2136344 + 285 WP_002441619.1 hypothetical protein -
EL290_RS10225 2136373..2136591 + 219 WP_002441617.1 hypothetical protein -
EL290_RS10230 2136893..2137219 + 327 WP_002441615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2128255..2129427 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7214.94 Da        Isoelectric Point: 9.7844

>T31910 WP_002441631.1 NZ_AP018585:2132970-2133158 [Staphylococcus caprae]
MNLHFQILLWLSIIFIVAGAIILAIMLKTKKEERKESYLGFTVIFLIFGFAMLIYTFIFGIL

Download         Length: 189 bp

>T31910 NZ_AP018585:2132970-2133158 [Staphylococcus caprae]
ATGAATTTACATTTTCAAATATTATTATGGCTTTCAATTATATTCATTGTTGCTGGTGCAATTATTTTAGCCATTATGCT
TAAAACGAAAAAAGAAGAGAGAAAAGAATCTTATTTAGGTTTTACGGTTATTTTCTTAATTTTCGGCTTTGCAATGCTCA
TTTATACATTTATTTTTGGTATATTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.80 Da        Isoelectric Point: 4.0612

>AT31910 WP_002441634.1 NZ_AP018585:2132682-2132939 [Staphylococcus caprae]
MKIISVNVINIILTVLFIAFNVLITYNANVDNHLWLIPGLCICGIALFTSLTIAIIYTDLLSEILFFINIVLALYYIYPI
FYDFL

Download         Length: 258 bp

>AT31910 NZ_AP018585:2132682-2132939 [Staphylococcus caprae]
ATGAAAATAATTAGTGTAAATGTGATTAATATCATCTTAACCGTACTATTTATAGCTTTTAATGTACTCATTACCTATAA
TGCAAACGTTGATAATCACCTATGGTTAATACCAGGATTATGTATTTGTGGTATTGCTCTATTTACGAGTTTAACAATAG
CAATTATTTATACTGATCTTTTAAGTGAAATTTTGTTCTTTATTAATATTGTCTTAGCACTTTACTATATTTATCCAATT
TTTTATGACTTCCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1GRH8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GRF3

References