Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2132682..2133158 Replicon chromosome
Accession NZ_AP018585
Organism Staphylococcus caprae strain JMUB145

Toxin (Protein)


Gene name TsaT Uniprot ID C5QQH5
Locus tag EL290_RS10195 Protein ID WP_002441631.1
Coordinates 2132970..2133158 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID C5QQH6
Locus tag EL290_RS10190 Protein ID WP_002441634.1
Coordinates 2132682..2132939 (+) Length 86 a.a.

Genomic Context

EL290_RS10160EL290_RS10165EL290_RS10170EL290_RS10180EL290_RS10190EL290_RS10195EL290_RS10200EL290_RS10215EL290_RS10220EL290_RS10225EL290_RS10230EL290_RS10175EL290_RS10185EL290_RS10205EL290_RS10210
Location: 2128255..2129427 (1173 bp)
Type: Others
Protein ID: WP_000195429.1
Location: 2129614..2130120 (507 bp)
Type: Others
Protein ID: WP_002441644.1
Location: 2130318..2130938 (621 bp)
Type: Others
Protein ID: WP_002441642.1
Location: 2131808..2132044 (237 bp)
Type: Others
Protein ID: WP_002441638.1
Location: 2132682..2132939 (258 bp)
Type: Antitoxin
Protein ID: WP_002441634.1
Location: 2132970..2133158 (189 bp)
Type: Toxin
Protein ID: WP_002441631.1
Location: 2133384..2133968 (585 bp)
Type: Others
Protein ID: WP_037541212.1
Location: 2135193..2135939 (747 bp)
Type: Others
Protein ID: WP_044466334.1
Location: 2136060..2136344 (285 bp)
Type: Others
Protein ID: WP_002441619.1
Location: 2136373..2136591 (219 bp)
Type: Others
Protein ID: WP_002441617.1
Location: 2136893..2137219 (327 bp)
Type: Others
Protein ID: WP_002441615.1
Location: 2131000..2131584 (585 bp)
Type: Others
Protein ID: WP_037541214.1
Location: 2132036..2132239 (204 bp)
Type: Others
Protein ID: WP_126493844.1
Location: 2134032..2134265 (234 bp)
Type: Others
Protein ID: WP_002441627.1
Location: 2134407..2135012 (606 bp)
Type: Others
Protein ID: WP_002441625.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL290_RS101602128255..2129427+1173WP_000195429.1IS256-like element IS256 family transposase-
EL290_RS101652129614..2130120+507WP_002441644.1GNAT family N-acetyltransferase-
EL290_RS101702130318..2130938+621WP_002441642.1LysE family transporter-
EL290_RS101752131000..2131584-585WP_037541214.1phosphoglycerate mutase family protein-
EL290_RS101802131808..2132044+237WP_002441638.1hypothetical protein-
EL290_RS101852132036..2132239-204WP_126493844.1sterile alpha motif-like domain-containing protein-
EL290_RS101902132682..2132939+258WP_002441634.1hypothetical proteinAntitoxin
EL290_RS101952132970..2133158+189WP_002441631.1hypothetical proteinToxin
EL290_RS102002133384..2133968+585WP_037541212.1orthopoxovirus protein, PF05708 family-
EL290_RS102052134032..2134265-234WP_002441627.1hypothetical protein-
EL290_RS102102134407..2135012-606WP_002441625.1GNAT family N-acetyltransferase-
EL290_RS102152135193..2135939+747WP_044466334.1poly-gamma-glutamate hydrolase family protein-
EL290_RS102202136060..2136344+285WP_002441619.1hypothetical protein-
EL290_RS102252136373..2136591+219WP_002441617.1hypothetical protein-
EL290_RS102302136893..2137219+327WP_002441615.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--2128255..21294271172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7214.94 Da        Isoelectric Point: 9.7844

>T31910 WP_002441631.1 NZ_AP018585:2132970-2133158 [Staphylococcus caprae]
MNLHFQILLWLSIIFIVAGAIILAIMLKTKKEERKESYLGFTVIFLIFGFAMLIYTFIFGIL

Download         Length: 189 bp

>T31910 NZ_AP018585:2132970-2133158 [Staphylococcus caprae]
ATGAATTTACATTTTCAAATATTATTATGGCTTTCAATTATATTCATTGTTGCTGGTGCAATTATTTTAGCCATTATGCT
TAAAACGAAAAAAGAAGAGAGAAAAGAATCTTATTTAGGTTTTACGGTTATTTTCTTAATTTTCGGCTTTGCAATGCTCA
TTTATACATTTATTTTTGGTATATTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.80 Da        Isoelectric Point: 4.0612

>AT31910 WP_002441634.1 NZ_AP018585:2132682-2132939 [Staphylococcus caprae]
MKIISVNVINIILTVLFIAFNVLITYNANVDNHLWLIPGLCICGIALFTSLTIAIIYTDLLSEILFFINIVLALYYIYPI
FYDFL

Download         Length: 258 bp

>AT31910 NZ_AP018585:2132682-2132939 [Staphylococcus caprae]
ATGAAAATAATTAGTGTAAATGTGATTAATATCATCTTAACCGTACTATTTATAGCTTTTAATGTACTCATTACCTATAA
TGCAAACGTTGATAATCACCTATGGTTAATACCAGGATTATGTATTTGTGGTATTGCTCTATTTACGAGTTTAACAATAG
CAATTATTTATACTGATCTTTTAAGTGAAATTTTGTTCTTTATTAATATTGTCTTAGCACTTTACTATATTTATCCAATT
TTTTATGACTTCCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1S1GRH8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1S1GRF3

References