Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1851785..1852575 Replicon chromosome
Accession NZ_AP018585
Organism Staphylococcus caprae strain JMUB145

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag EL290_RS08830 Protein ID WP_126493827.1
Coordinates 1852111..1852575 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EL290_RS08825 Protein ID WP_087671659.1
Coordinates 1851785..1852099 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL290_RS08775 1846860..1847540 - 681 WP_126493820.1 hypothetical protein -
EL290_RS08780 1847541..1848092 - 552 WP_126493821.1 NUMOD4 motif-containing HNH endonuclease -
EL290_RS08785 1848105..1848524 - 420 WP_126493822.1 single-stranded DNA-binding protein -
EL290_RS08790 1848521..1849168 - 648 WP_126493823.1 ERF family protein -
EL290_RS08795 1849161..1849382 - 222 WP_095323496.1 DUF2483 family protein -
EL290_RS08800 1849382..1849630 - 249 WP_126493824.1 chordopoxvirus fusion protein -
EL290_RS12705 1849692..1849865 - 174 WP_162837223.1 hypothetical protein -
EL290_RS08805 1849879..1850088 - 210 WP_002442287.1 hypothetical protein -
EL290_RS08810 1850176..1850382 + 207 WP_002436523.1 hypothetical protein -
EL290_RS12710 1850368..1850517 - 150 WP_172595384.1 hypothetical protein -
EL290_RS08815 1850623..1851384 - 762 WP_126493825.1 phage regulatory protein/antirepressor Ant -
EL290_RS08820 1851403..1851633 - 231 WP_126493826.1 helix-turn-helix domain-containing protein -
EL290_RS08825 1851785..1852099 + 315 WP_087671659.1 helix-turn-helix domain-containing protein Antitoxin
EL290_RS08830 1852111..1852575 + 465 WP_126493827.1 ImmA/IrrE family metallo-endopeptidase Toxin
EL290_RS08835 1852745..1853116 + 372 Protein_1702 Abi family protein -
EL290_RS08840 1853199..1855106 + 1908 WP_095323322.1 N-6 DNA methylase -
EL290_RS08845 1855090..1856109 + 1020 WP_095323321.1 restriction endonuclease subunit S -
EL290_RS08850 1856170..1857216 + 1047 WP_126493828.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1815630..1857984 42354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(15-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18238.84 Da        Isoelectric Point: 6.5872

>T31909 WP_126493827.1 NZ_AP018585:1852111-1852575 [Staphylococcus caprae]
MGLYEKMLIEHDYIEVRETDVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELAHHKLTYGNILDQSKWINRKFESYAR
RHGYEAALPLHIIVEAHHYGVSSLYELADYVQLSEKYIVEILEHYKNKYGIGTNYANYAITFEPLRVYGYKNIK

Download         Length: 465 bp

>T31909 NZ_AP018585:1852111-1852575 [Staphylococcus caprae]
ATGGGGTTATATGAAAAAATGTTAATAGAGCATGACTATATAGAAGTCAGAGAAACAGATGTTATGCCTAATGACTTACA
TGGTTTATGGTTAGGTGATTTAATTCTAATCAAACGCAACCTATCCGAAACACGCAAAGCCGAAGTCTTATACGAAGAAC
TAGCACATCACAAACTTACATATGGTAATATCTTAGATCAGTCTAAATGGATTAACCGTAAATTTGAAAGCTACGCAAGA
CGTCATGGATACGAGGCAGCACTACCCCTACACATTATTGTGGAGGCACATCACTATGGAGTGAGTAGCTTATATGAACT
AGCTGATTATGTTCAACTAAGTGAAAAGTACATAGTAGAGATACTGGAACATTATAAAAATAAATATGGTATTGGAACTA
ACTACGCCAATTACGCTATTACGTTTGAGCCGTTGAGAGTATATGGATATAAAAATATAAAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12019.60 Da        Isoelectric Point: 8.0297

>AT31909 WP_087671659.1 NZ_AP018585:1851785-1852099 [Staphylococcus caprae]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIDESDEQTQHRAAHL
EGELTDDEWKRVLDYADFIRSKRK

Download         Length: 315 bp

>AT31909 NZ_AP018585:1851785-1852099 [Staphylococcus caprae]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTAGCTGAACTAGGAAGAAAAATCGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGTGGAAATATCAAAAATCTTAAAAACGATACTATCGAAAGCATAGCTACGG
CATTAAATGTTAACCCTGCATTTTTGATGGGTTGGATAGATGAAAGTGATGAACAAACACAACATCGTGCAGCTCATCTT
GAGGGAGAATTAACTGATGACGAATGGAAACGAGTTTTAGATTATGCTGATTTTATAAGAAGTAAACGTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References