Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1103071..1103874 Replicon chromosome
Accession NZ_AP018585
Organism Staphylococcus caprae strain JMUB145

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag EL290_RS05330 Protein ID WP_126493726.1
Coordinates 1103695..1103874 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag EL290_RS05325 Protein ID WP_037541523.1
Coordinates 1103071..1103670 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL290_RS05305 1098959..1100416 + 1458 WP_044466434.1 ABC transporter substrate-binding protein/permease -
EL290_RS05310 1100409..1101131 + 723 WP_002443573.1 amino acid ABC transporter ATP-binding protein -
EL290_RS05315 1101291..1102418 + 1128 WP_002443571.1 tRNA epoxyqueuosine(34) reductase QueG -
EL290_RS05320 1102421..1102891 + 471 WP_002443570.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL290_RS05325 1103071..1103670 + 600 WP_037541523.1 glucosamine-6-phosphate isomerase Antitoxin
EL290_RS05330 1103695..1103874 + 180 WP_126493726.1 hypothetical protein Toxin
EL290_RS05335 1104110..1104508 + 399 WP_002443564.1 hypothetical protein -
EL290_RS05340 1104661..1106046 + 1386 WP_002443562.1 class II fumarate hydratase -
EL290_RS05345 1106146..1106973 - 828 WP_002443561.1 RluA family pseudouridine synthase -
EL290_RS05350 1107152..1108264 + 1113 WP_002443558.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6981.44 Da        Isoelectric Point: 3.9152

>T31908 WP_126493726.1 NZ_AP018585:1103695-1103874 [Staphylococcus caprae]
MAKEQESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDIRSDLQDK

Download         Length: 180 bp

>T31908 NZ_AP018585:1103695-1103874 [Staphylococcus caprae]
ATGGCTAAAGAACAAGAATCTAAATTGAATTATCATGAAGAAGAAAATGCAATGGTGACAGATTTAGATGATTTGAAAGA
ATTAGGTAAAGAAATGGAGCAAATTTCAGAAGAGAATGATGAAGACAAACTGAATCAATCTCATGACGAAGACATACGTT
CCGACCTACAAGATAAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22694.63 Da        Isoelectric Point: 4.7838

>AT31908 WP_037541523.1 NZ_AP018585:1103071-1103670 [Staphylococcus caprae]
MAMNFKVFDNNERVAEYAADIIRKQFNNNPTTIAGFHLDKDQAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEKDAIEFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKRDVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFV

Download         Length: 600 bp

>AT31908 NZ_AP018585:1103071-1103670 [Staphylococcus caprae]
ATGGCAATGAACTTTAAAGTATTTGATAATAATGAAAGAGTAGCAGAATACGCTGCTGATATTATTCGTAAACAATTTAA
TAACAATCCTACAACAATTGCAGGATTTCATTTAGACAAGGACCAAGCGCCTGTTTTAGATGAACTTAAGAAAAACGTTG
ATACACACGCTGTAGACTTTAGTCAAATCAATATCTTAGATTATGACGACAATCGCTCTTATTATGAAGCTTTAGGAGTA
CCTGAAAGTCAAGTTTATTCAATCTCTTATGAAAAAGATGCAATTGAATTTATCTCAGATAAAATGAAAACGAAAGAAAA
TAAAGGAAAATTAATCCTTCAAGTTCTTTCTATAGATGAAAGTGGCAAATTAGATGTTAGCGTACGACAAGGTTTAATGG
AAGCTAGAGAAATCTTCTTAGTAGTCACTGGTAGCAATAAACGTGATGTGATTGAGAAATTATATCGTGAAAATGGTAAA
TCTAGTTATGAACCAGCAGATTTAAAAGCACATCGTATGGTTAATGTTATCTTAGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGACGTTAAAGAGTACTTCACAGCACGTTTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References