Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 951328..951857 Replicon chromosome
Accession NZ_AP018585
Organism Staphylococcus caprae strain JMUB145

Toxin (Protein)


Gene name mazF Uniprot ID C5QLA1
Locus tag EL290_RS04495 Protein ID WP_002445525.1
Coordinates 951495..951857 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1S1GX41
Locus tag EL290_RS04490 Protein ID WP_037541853.1
Coordinates 951328..951498 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL290_RS04465 947143..947622 + 480 WP_126493718.1 PH domain-containing protein -
EL290_RS04470 947615..949114 + 1500 WP_044466353.1 PH domain-containing protein -
EL290_RS04475 949101..949643 + 543 WP_044466352.1 PH domain-containing protein -
EL290_RS04480 949658..950014 + 357 WP_044466351.1 holo-ACP synthase -
EL290_RS04485 950092..951240 + 1149 WP_002445529.1 alanine racemase -
EL290_RS04490 951328..951498 + 171 WP_037541853.1 hypothetical protein Antitoxin
EL290_RS04495 951495..951857 + 363 WP_002445525.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL290_RS04500 952229..953230 + 1002 WP_044466350.1 PP2C family protein-serine/threonine phosphatase -
EL290_RS04505 953333..953659 + 327 WP_037541852.1 anti-sigma factor antagonist -
EL290_RS04510 953661..954140 + 480 WP_002445522.1 anti-sigma B factor RsbW -
EL290_RS04515 954115..954885 + 771 WP_002445521.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13511.68 Da        Isoelectric Point: 10.0250

>T31907 WP_002445525.1 NZ_AP018585:951495-951857 [Staphylococcus caprae]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHPKS

Download         Length: 363 bp

>T31907 NZ_AP018585:951495-951857 [Staphylococcus caprae]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTGCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTCGT
TATTATTCAAAACGATACTGGTAATAAATATAGTCCTACAGTCATTGTGGCTGCTATTACAGGTAGGATTAATAAAGCGA
AAATACCAACCCATGTAGAAATTGAAAAGAAAAAGTACAAGTTAGATAAAGATTCCGTTATCCTACTTGAACAAATTAGA
ACACTTGATAAAAAACGATTAAAAGAAAAATTGACCTATTTATCTGAAAGTAAGATGAAAGAGGTCGACAACGCCCTAGA
CATTAGTCTAGGCTTACATAACTTTGATCATCCAAAATCATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6290.90 Da        Isoelectric Point: 4.0121

>AT31907 WP_037541853.1 NZ_AP018585:951328-951498 [Staphylococcus caprae]
MLSFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT31907 NZ_AP018585:951328-951498 [Staphylococcus caprae]
ATGTTATCTTTTAATCAAAATAGAAGTCACAGTCTTGAACAATCCTTAAAAGAAGGTTATGCACAAATGGCTGATCTAAA
CCTCTCCCTAGCGACGGAAGCTTTCCCGATTGAGTGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1GUI8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GX41

References