31899

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1918285..1919072 Replicon chromosome
Accession NZ_AP018562
Organism Staphylococcus argenteus strain 58113

Toxin (Protein)


Gene name tsbT Uniprot ID A0A7U7PZK3
Locus tag SA58113_RS09320 Protein ID WP_000031103.1
Coordinates 1918285..1918440 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A7U7JVF2
Locus tag SA58113_RS09325 Protein ID WP_047430475.1
Coordinates 1918473..1919072 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA58113_RS09300 1913473..1914585 - 1113 WP_031787927.1 GAF domain-containing sensor histidine kinase -
SA58113_RS09305 1914747..1915568 + 822 WP_000669386.1 RluA family pseudouridine synthase -
SA58113_RS09310 1915862..1917247 - 1386 WP_031787928.1 class II fumarate hydratase -
SA58113_RS09315 1917418..1917819 - 402 WP_000901017.1 hypothetical protein -
SA58113_RS09320 1918285..1918440 - 156 WP_000031103.1 hypothetical protein Toxin
SA58113_RS09325 1918473..1919072 - 600 WP_047430475.1 glucosamine-6-phosphate isomerase Antitoxin
SA58113_RS09330 1919231..1919701 - 471 WP_000181399.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
SA58113_RS09335 1919703..1920833 - 1131 WP_031787930.1 tRNA epoxyqueuosine(34) reductase QueG -
SA58113_RS09340 1920984..1921706 - 723 WP_031787931.1 amino acid ABC transporter ATP-binding protein -
SA58113_RS09345 1921699..1923156 - 1458 WP_000649887.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6019.42 Da        Isoelectric Point: 4.1469

>T31899 WP_000031103.1 NZ_AP018562:c1918440-1918285 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Download         Length: 156 bp

>T31899 NZ_AP018562:c1918440-1918285 [Staphylococcus argenteus]
ATGTCTAAAGATAAAGATGCAAAATTAAATTATCACGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAGATGGAACAAATTTCAGATCAAAATGATCAAGAGAAGAGTACTGATGAAAAGAATAGCCATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22438.57 Da        Isoelectric Point: 5.3935

>AT31899 WP_047430475.1 NZ_AP018562:c1919072-1918473 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT31899 NZ_AP018562:c1919072-1918473 [Staphylococcus argenteus]
ATGGCAATGAACTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGAATATGCTGCAGATATTATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTGGATACAGACCAAGCACCAGTATTAGATGAACTAAAGAAAAATGTTG
AGAAACACGCTGTTGATTTTAGTCAAATAAATATTTTAGATTATGACAATAAAAAATCTTATTTTGAAGCATTAGGCGTG
CCAGCAAGTCAAATCTATCCAATTGCGTTTGAAAAAGATGCTATTGAATTTATCTCTGACAAAATTAAAACTAAAGAAAA
TAAAGGCAAACTAACATTACAAGTTGTTTCTATTGATGAGCAAGGAAAATTAAATGTTAGTATCCGCCAAGGTTTAATGG
AAGCGAGAGAAATATTTTTAGTTGTGACAGGTGCTAATAAAAAGGAAGTTGTTGAAAAATTATACCAAGAAAATGGTAAA
ACAAGTTTCGAACCATCTGACTTAAAATCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTCAAAGCTTACTTTACATCTCGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PZK3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JVF2

References