Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 849266..849743 Replicon chromosome
Accession NZ_AP018562
Organism Staphylococcus argenteus strain 58113

Toxin (Protein)


Gene name TsaT Uniprot ID A0A7U7JTG2
Locus tag SA58113_RS04110 Protein ID WP_000172413.1
Coordinates 849266..849454 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A7U7JTE3
Locus tag SA58113_RS04115 Protein ID WP_000790107.1
Coordinates 849483..849743 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA58113_RS04080 844962..845444 + 483 WP_031788350.1 hypothetical protein -
SA58113_RS04085 845787..846455 + 669 WP_031788100.1 thermonuclease family protein -
SA58113_RS04090 846819..847019 + 201 WP_001059082.1 cold-shock protein -
SA58113_RS04095 847632..847844 - 213 WP_001007088.1 hypothetical protein -
SA58113_RS04100 847905..848189 - 285 WP_031788101.1 hypothetical protein -
SA58113_RS04105 848278..848847 - 570 WP_031788102.1 hypothetical protein -
SA58113_RS04110 849266..849454 - 189 WP_000172413.1 hypothetical protein Toxin
SA58113_RS04115 849483..849743 - 261 WP_000790107.1 hypothetical protein Antitoxin
SA58113_RS04120 850083..850286 + 204 WP_000145167.1 sterile alpha motif-like domain-containing protein -
SA58113_RS04125 850283..850519 - 237 WP_000368686.1 hypothetical protein -
SA58113_RS04130 850744..851325 + 582 WP_031788103.1 phosphoglycerate mutase family protein -
SA58113_RS04135 851392..852009 - 618 WP_031788104.1 LysE family transporter -
SA58113_RS04140 852173..852664 - 492 WP_000695603.1 GNAT family N-acetyltransferase -
SA58113_RS04145 853071..853493 - 423 WP_001007646.1 organic hydroperoxide resistance protein -
SA58113_RS04150 853642..854361 + 720 WP_047451209.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.89 Da        Isoelectric Point: 9.9971

>T31895 WP_000172413.1 NZ_AP018562:c849454-849266 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Download         Length: 189 bp

>T31895 NZ_AP018562:c849454-849266 [Staphylococcus argenteus]
ATGACTTTACATTTTGCAATTTTATTTTGGCTAGCATTAATTTTTATCGTTGCTGGTACATTTATATTTGTCTTAATGAA
AAAAACTGCTAAAGAATCTAAAAAAGAATCTTATTTAAGCTTCGCTGTTATTTTCTATATTTTTGGATTCGCAATGCTAA
TTTATACATTAATATTTGGAATTCTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10089.30 Da        Isoelectric Point: 4.1927

>AT31895 WP_000790107.1 NZ_AP018562:c849743-849483 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Download         Length: 261 bp

>AT31895 NZ_AP018562:c849743-849483 [Staphylococcus argenteus]
ATGAAAAACATTCAATTAAATGCTATAAATTTAGTTATAACAATCATATTTGCTATCTTTAACATTATGATTACATATAA
CAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGCATTATCATTTGCGGTTCGATACTCATTGTATCGTTTACCATTG
CAATGATTACTAAATTCTGGTTAAGTGAAATATTATTTTTTATTAACATCGTGCTCGTTCTTTATTATATTTATCCAATT
TTTTATGATTTCATTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JTG2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JTE3

References