Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 8028..8572 Replicon plasmid pTH1
Accession NZ_AP018559
Organism Hydrogenophilus thermoluteolus strain TH-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HPTL_RS10845 Protein ID WP_179949102.1
Coordinates 8028..8354 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HPTL_RS10850 Protein ID WP_119336199.1
Coordinates 8351..8572 (-) Length 74 a.a.

Genomic Context

HPTL_RS11225HPTL_RS11310HPTL_RS10865HPTL_RS10870HPTL_RS10885HPTL_RS10890HPTL_RS10895HPTL_RS10820HPTL_RS10825HPTL_RS10830HPTL_RS10835HPTL_RS10840HPTL_RS10845HPTL_RS10850HPTL_RS10855HPTL_RS10860HPTL_RS11340
Location: 3611..3850 (240 bp)
Type: Others
Protein ID: WP_145981821.1
Location: 7519..7662 (144 bp)
Type: Others
Protein ID: Protein_10
Location: 10829..11242 (414 bp)
Type: Others
Protein ID: WP_119336202.1
Location: 11196..11516 (321 bp)
Type: Others
Protein ID: WP_119336203.1
Location: 12603..12770 (168 bp)
Type: Others
Protein ID: WP_179949104.1
Location: 12812..13048 (237 bp)
Type: Others
Protein ID: WP_119336204.1
Location: 13045..13476 (432 bp)
Type: Others
Protein ID: WP_119336205.1
Location: 3980..4306 (327 bp)
Type: Others
Protein ID: WP_119336194.1
Location: 4293..4523 (231 bp)
Type: Others
Protein ID: WP_119336195.1
Location: 4597..6261 (1665 bp)
Type: Others
Protein ID: WP_119336196.1
Location: 6251..6634 (384 bp)
Type: Others
Protein ID: WP_119336197.1
Location: 7670..7921 (252 bp)
Type: Others
Protein ID: WP_119336198.1
Location: 8028..8354 (327 bp)
Type: Toxin
Protein ID: WP_179949102.1
Location: 8351..8572 (222 bp)
Type: Antitoxin
Protein ID: WP_119336199.1
Location: 8729..10003 (1275 bp)
Type: Others
Protein ID: WP_119336200.1
Location: 9997..10626 (630 bp)
Type: Others
Protein ID: WP_119336201.1
Location: 11629..12159 (531 bp)
Type: Others
Protein ID: WP_179949103.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HPTL_RS112253611..3850+240WP_145981821.1hypothetical protein-
HPTL_RS108203980..4306-327WP_119336194.1type II toxin-antitoxin system PemK/MazF family toxin-
HPTL_RS108254293..4523-231WP_119336195.1addiction module antitoxin-
HPTL_RS108304597..6261-1665WP_119336196.1relaxase/mobilization nuclease domain-containing protein-
HPTL_RS108356251..6634-384WP_119336197.1plasmid mobilization relaxosome protein MobC-
HPTL_RS113107519..7662+144Protein_10ATP-binding protein-
HPTL_RS108407670..7921-252WP_119336198.1hypothetical protein-
HPTL_RS108458028..8354-327WP_179949102.1type II toxin-antitoxin system PemK/MazF family toxinToxin
HPTL_RS108508351..8572-222WP_119336199.1antitoxin MazE family proteinAntitoxin
HPTL_RS108558729..10003-1275WP_119336200.1transposase-
HPTL_RS108609997..10626-630WP_119336201.1IS607 family transposase-
HPTL_RS1086510829..11242+414WP_119336202.1type II toxin-antitoxin system RelE/ParE family toxin-
HPTL_RS1087011196..11516+321WP_119336203.1DNA-binding transcriptional regulator-
HPTL_RS1134011629..12159-531WP_179949103.1hypothetical protein-
HPTL_RS1088512603..12770+168WP_179949104.1hypothetical protein-
HPTL_RS1089012812..13048+237WP_119336204.1ribbon-helix-helix protein, CopG family-
HPTL_RS1089513045..13476+432WP_119336205.1putative toxin-antitoxin system toxin component, PIN family-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-ureB / ureA1..6563765637


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(14-105)

Antitoxin

Antitoxin MazE-like

(7-71)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11893.00 Da        Isoelectric Point: 9.2935

>T31889 WP_179949102.1 NZ_AP018559:c8354-8028 [Hydrogenophilus thermoluteolus]
MMRGDLVTIVTQGDFGKPRPALVIQSDLFNELSSITVFPVTSTIVDAPLLRVTVEPTPENGLHKRSQVMVDKIMTVRRDK
VGQIIGRIDTTTLTTIERCLAVFLGIAK

Download         Length: 327 bp

>T31889 NZ_AP018559:c8354-8028 [Hydrogenophilus thermoluteolus]
ATGATGCGCGGCGATTTGGTAACGATCGTTACCCAGGGCGACTTTGGCAAACCAAGGCCAGCGTTGGTGATCCAGTCCGA
TCTGTTCAACGAGCTCAGCAGCATAACCGTCTTTCCTGTAACCAGTACCATTGTGGATGCCCCGTTGTTGCGCGTCACGG
TTGAGCCAACCCCGGAAAACGGCTTGCACAAGCGATCACAGGTGATGGTGGACAAAATTATGACCGTGCGGCGGGACAAA
GTCGGTCAGATCATTGGACGTATCGATACGACTACGCTGACAACGATCGAGCGCTGCTTAGCTGTCTTCTTGGGAATCGC
GAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8394.66 Da        Isoelectric Point: 9.3851

>AT31889 WP_119336199.1 NZ_AP018559:c8572-8351 [Hydrogenophilus thermoluteolus]
MTVPVKARVQKYRDALRRSGLRPVQIWVPDTRRPGFAQECRRQCLLVTQADAADTQLQRLMDEALAEIDGWQA

Download         Length: 222 bp

>AT31889 NZ_AP018559:c8572-8351 [Hydrogenophilus thermoluteolus]
ATGACAGTACCGGTCAAAGCGCGTGTTCAAAAGTATCGCGACGCGCTGCGCCGCTCGGGTTTGCGTCCGGTTCAGATCTG
GGTACCGGATACCCGCCGCCCGGGCTTTGCACAAGAGTGTCGCCGCCAGTGCCTGCTCGTGACCCAGGCAGACGCCGCTG
ATACGCAACTCCAACGACTCATGGATGAAGCCTTGGCAGAGATTGATGGCTGGCAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References