Detailed information of TA system TA031888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 23726..24248
• Replicon: chromosome
• Accession: NZ_AP018558
• Organism: Hydrogenophilus thermoluteolus strain TH-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPTL_RS00095
• Protein ID: WP_170141356.1
• Coordinates: 23994..24248 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HPTL_RS00090
• Protein ID: WP_119334150.1
• Coordinates: 23726..23983 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPTL_RS00090	23726..23983	+	258	WP_119334150.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HPTL_RS00095	23994..24248	+	255	WP_170141356.1	Txe/YoeB family addiction module toxin	Toxin
HPTL_RS00100	24274..25056	+	783	WP_119334152.1	cytochrome b/b6 domain-containing protein	-
HPTL_RS00105	25120..25584	-	465	WP_119334153.1	cytochrome c	-
HPTL_RS00110	25705..27270	-	1566	WP_119334154.1	CZB domain-containing protein	-
HPTL_RS00115	27283..27819	-	537	WP_119334155.1	PAS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10071.55 Da
• Isoelectric Point: 7.7729

>T31888 WP_170141356.1 NZ_AP018558:23994-24248 [Hydrogenophilus thermoluteolus]
MKLTWTLAAWEDYQYWQSQDKKTLKRINALIQDCLRHPFEGIGKPEPLRENLSGFWSRRIDETHRLVYCVDGEALVVIAC
RYHY

Nucleotide

• Length: 255 bp

>T31888 NZ_AP018558:23994-24248 [Hydrogenophilus thermoluteolus]
TTGAAACTCACCTGGACCCTGGCGGCGTGGGAAGATTATCAATATTGGCAAAGTCAGGACAAAAAGACCTTGAAGCGCAT
CAATGCATTGATCCAAGACTGTTTGCGCCATCCGTTCGAAGGCATCGGCAAACCCGAACCGTTGCGCGAGAACCTTTCGG
GTTTCTGGTCACGCCGCATTGACGAGACCCACCGCTTGGTCTACTGTGTCGATGGCGAAGCGTTGGTGGTGATTGCGTGC
CGTTACCACTACTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9535.82 Da
• Isoelectric Point: 5.6306

>AT31888 WP_119334150.1 NZ_AP018558:23726-23983 [Hydrogenophilus thermoluteolus]
MRVVNFSEARNNLKRVIDQVIADADYTIIVRRDAPDAVVLSLETFNSLMETVHLLKSPANAAHLARSLAQYRQGQVTQQD
LIDAE

Nucleotide

• Length: 258 bp

>AT31888 NZ_AP018558:23726-23983 [Hydrogenophilus thermoluteolus]
ATGCGCGTAGTCAATTTTTCCGAAGCCCGGAACAACCTCAAACGGGTGATCGACCAGGTCATTGCCGACGCCGACTATAC
GATCATCGTCCGTCGGGATGCTCCCGATGCGGTGGTGCTGTCGCTGGAAACCTTCAACAGCCTGATGGAGACGGTTCATC
TCCTCAAATCACCCGCGAATGCTGCTCACCTCGCGCGTTCGCTCGCGCAGTACCGTCAGGGTCAAGTGACGCAGCAGGAC
TTGATCGATGCCGAGTGA