Detailed information of TA system TA031887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 738988..739594
• Replicon: chromosome
• Accession: NZ_AP018553
• Organism: Sulfodiicoccus acidiphilus strain HS-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HS1genome_RS03880
• Protein ID: WP_126449696.1
• Coordinates: 738988..739380 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HS1genome_RS03885
• Protein ID: WP_126449697.1
• Coordinates: 739370..739594 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HS1genome_RS03845 (HS1genome_0752)	734450..734863	-	414	WP_126449692.1	hypothetical protein	-
HS1genome_RS03850 (HS1genome_0753)	734918..735565	+	648	WP_126449693.1	hypothetical protein	-
HS1genome_RS03855 (HS1genome_0754)	735562..736023	-	462	WP_126449694.1	DNA starvation/stationary phase protection protein	-
HS1genome_RS03860 (HS1genome_0755)	736070..736873	-	804	WP_126449695.1	ParA family protein	-
HS1genome_RS03865	737281..738237	+	957	Protein_754	IS5/IS1182 family transposase	-
HS1genome_RS03880 (HS1genome_0760)	738988..739380	-	393	WP_126449696.1	type II toxin-antitoxin system VapC family toxin	Toxin
HS1genome_RS03885 (HS1genome_0761)	739370..739594	-	225	WP_126449697.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HS1genome_RS12530	740081..740173	-	93	WP_229768104.1	hypothetical protein	-
HS1genome_RS03895	741261..741467	-	207	WP_126449698.1	sulfocyanin	-
HS1genome_RS03900 (HS1genome_0762)	741604..741978	+	375	WP_126449699.1	hypothetical protein	-
HS1genome_RS12535	742453..742599	-	147	Protein_760	transposase	-
HS1genome_RS03905 (HS1genome_0763)	742905..743885	-	981	WP_126451303.1	pyridoxal-phosphate dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (23-118)

Antitoxin

• Post-segregation antitoxin CcdA (5-46)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 15118.72 Da
• Isoelectric Point: 8.2638

>T31887 WP_126449696.1 NZ_AP018553:c739380-738988 [Sulfodiicoccus acidiphilus]
MKDREFLFDASALYSLLDYADKVDIKKIHILTLTFYEVGNAIWKEYYIHKKVKDPITLSKLFYELMRRFNVVDDPPLEGV
MRIAIERGLTYYDAAYAYVAESLGLILVSNDKELIRKANAISLKNLIKSM

Nucleotide

• Length: 393 bp

>T31887 NZ_AP018553:c739380-738988 [Sulfodiicoccus acidiphilus]
ATGAAAGATAGGGAATTCCTATTCGATGCCTCAGCTTTATATTCGCTTTTAGATTACGCGGATAAAGTAGATATTAAGAA
AATTCACATACTCACCTTAACTTTTTATGAGGTAGGTAATGCTATATGGAAGGAGTATTATATACATAAGAAGGTTAAAG
ATCCTATAACACTTTCTAAACTTTTCTATGAATTAATGCGAAGGTTTAACGTAGTAGACGATCCGCCTCTTGAAGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATGACGCGGCTTATGCATACGTTGCCGAATCTTTAGGGCTTATCCT
TGTATCTAACGATAAAGAGTTAATAAGAAAAGCTAATGCTATTTCGTTAAAGAATTTGATAAAAAGTATGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8820.23 Da
• Isoelectric Point: 4.8365

>AT31887 WP_126449697.1 NZ_AP018553:c739594-739370 [Sulfodiicoccus acidiphilus]
MSDVISVRVKKELKKKAEELGINIREVVEKALEESIMEKEKEELRDMAMKIKELMKDVSEDDWIRAVRESRDER

Nucleotide

• Length: 225 bp

>AT31887 NZ_AP018553:c739594-739370 [Sulfodiicoccus acidiphilus]
ATGTCAGACGTAATAAGCGTAAGAGTTAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGCTAGGAATTAATATTAGGGAAGT
TGTAGAAAAGGCACTAGAGGAATCAATAATGGAGAAGGAAAAGGAAGAGCTTAGGGATATGGCTATGAAAATTAAGGAAC
TAATGAAGGATGTAAGCGAAGATGATTGGATAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAG